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  4. Recombinant Human Poly (A)-specific ribonuclease PARN-like domain-containing protein 1 (PNLDC1), partial

Recombinant Human Poly (A)-specific ribonuclease PARN-like domain-containing protein 1 (PNLDC1), partial

  • 中文名称：
    人PNLDC1重组蛋白
  • 货号：
    CSB-YP818744HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PNLDC1重组蛋白
  • 货号：
    CSB-EP818744HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PNLDC1重组蛋白
  • 货号：
    CSB-EP818744HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PNLDC1重组蛋白
  • 货号：
    CSB-BP818744HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PNLDC1重组蛋白
  • 货号：
    CSB-MP818744HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PNLDC1
  • Uniprot No.：
  • 别名：
    oly(A)-specific ribonuclease PARN-like domain-containing protein 1; PNDC1_HUMAN; PNLDC1; poly(A)-specific ribonuclease (PARN)-like domain containing 1; Poly(A)-specific ribonuclease PARN-like domain-containing protein 1; RP1-195P10.1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. May act as a regulator of multipotency in embryonic stem cells.
  • 基因功能参考文献：
    1. we describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder. Using whole-genome sequencing, we delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis. PMID: 27260655
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    CAF1 family
  • 数据库链接：

    HGNC: 21185

    KEGG: hsa:154197

    STRING: 9606.ENSP00000275275

    UniGene: Hs.349077