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  4. Recombinant Human Pre-B-cell leukemia transcription factor 3 (PBX3)

Recombinant Human Pre-B-cell leukemia transcription factor 3 (PBX3)

  • 中文名称：
    人PBX3重组蛋白
  • 货号：
    CSB-YP017507HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PBX3重组蛋白
  • 货号：
    CSB-EP017507HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PBX3重组蛋白
  • 货号：
    CSB-EP017507HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PBX3重组蛋白
  • 货号：
    CSB-BP017507HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PBX3重组蛋白
  • 货号：
    CSB-MP017507HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PBX3
  • Uniprot No.：
  • 别名：
    Homeobox protein PBX3; MGC134053 ; OTTHUMP00000064213; Pbx 3; Pbx3; PBX3_HUMAN; Pre B cell leukemia homeobox 3; Pre B cell leukemia transcription factor 3; Pre-B-cell leukemia transcription factor 3; RP11 336P12.1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-434
  • 氨基酸序列
    MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.
  • 基因功能参考文献：
    1. the present study indicates that PBX 3'UTR may induce inflammatory responses and sepsis via acting as a competing endogenous RNA for HMGB1. PMID: 29484406
    2. Results show that PBX3 expression is increased in both human glioma tissues and cell lines. Furthermore, silencing of PBX3 remarkably reduced glioma cell proliferation and induced apoptosis, while PBX3 overexpression dramatically increased glioma cell proliferation. Finally, PBX3 promoted glioma cell proliferation by modulating cell cycle progression. PMID: 28856521
    3. Silencing PBX3 inhibited the migratory and invasive capacities of glioma cells. PMID: 28124208
    4. miR-33a-3p suppressed the malignant phenotype while also inhibiting PBX3 expression in hepatocellular cancer PMID: 27285759
    5. Results found that PBX3 is epigenetically aberrant in leukemia stem cell maintenance of MLL-rearranged AML and is essential for leukemia development. PMID: 28411381
    6. results suggest that miR-144-3p suppresses GC progression by inhibiting EMT through targeting PBX3 PMID: 28111340
    7. Patients undergoing radical prostatectomy, with high levels of PBX3 mRNA, had improved prostate cancer specific survival compared to patients expressing low levels. PMID: 27273830
    8. Our findings collectively indicate that miR-320a inhibits cell proliferation and induces apoptosis in MM cells by directly targeting PBX3, supporting its utility as a novel and potential therapeutic agent for miRNA-based MM therapy. PMID: 27086852
    9. Studies implicate PBX3/MEIS1 interaction as a driver of cell transformation and leukemogenesis, and that this axis may play a critical role in the regulation of the core transcriptional programs activated in MLL-rearranged and HOX-overexpressing AML. PMID: 26747896
    10. let-7c, miR-200b, miR-222 and miR-424 target PBX3, which is necessary for the acquisition and maintenance of liver tumour-initiating cells properties. PMID: 26420065
    11. Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein. PMID: 26130510
    12. PBX3 induces invasion and metastasis of colorectal caner cells partially through activation of the MAPK/ERK signaling pathway. PMID: 25561793
    13. An intermediate-risk group of acute myeloid leukemia patients compared to a group with a favorable risk reduces to a four-gene signature of HOXA6, HOXA9, PBX3 and MEIS1 by iterative analysis of independent platforms. PMID: 23539541
    14. matrigel invasion assay showed that PBX3 transfection also increased cell-invading ability PMID: 24375258
    15. Increased expression of PBX3 is associated with pilocytic astrocytoma. PMID: 23161775
    16. Collectively, our data suggest that PBX3 is a critical cofactor of HOXA9 in leukemogenesis. PMID: 23264595
    17. The Pbx3 Ala136Val variant is a modifier or risk allele for congenital heart defects. PMID: 22426282
    18. Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). PMID: 22251480
    19. PBX3 is up-regulated in prostate cancer and post- transcriptionally regulated by androgen through Let-7d. PMID: 21548940
    20. our results seem to discard the role of the previously described polymorphisms in SERPINE2, PPP6C and PBX3 in celiac disease susceptibility. PMID: 19626039

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/PBX homeobox family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 8634

    OMIM: 176312

    KEGG: hsa:5090

    STRING: 9606.ENSP00000362588

    UniGene: Hs.428027