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  4. Recombinant Human Probable rRNA-processing protein EBP2 (EBNA1BP2)

Recombinant Human Probable rRNA-processing protein EBP2 (EBNA1BP2)

  • 中文名称：
    人EBNA1BP2重组蛋白
  • 货号：
    CSB-YP860781HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EBNA1BP2重组蛋白
  • 货号：
    CSB-EP860781HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EBNA1BP2重组蛋白
  • 货号：
    CSB-EP860781HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EBNA1BP2重组蛋白
  • 货号：
    CSB-BP860781HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EBNA1BP2重组蛋白
  • 货号：
    CSB-MP860781HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EBNA1BP2
  • Uniprot No.：
  • 别名：
    EBNA1BP2; EBP2Probable rRNA-processing protein EBP2; EBNA1-binding protein 2; Nucleolar protein p40
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-306
  • 氨基酸序列
    MDTPPLSDSE SESDESLVTD RELQDAFSRG LLKPGLNVVL EGPKKAVNDV NGLKQCLAEF KRDLEWVERL DVTLGPVPEI GGSEAPAPQN KDQKAVDPED DFQREMSFYR QAQAAVLAVL PRLHQLKVPT KRPTDYFAEM AKSDLQMQKI RQKLQTKQAA MERSEKAKQL RALRKYGKKV QTEVLQKRQQ EKAHMMNAIK KYQKGFSDKL DFLEGDQKPL AQRKKAGAKG QQMRKGPSAK RRYKNQKFGF GGKKKGSKWN TRESYDDVSS FRAKTAHGRG LKRPGKKGSN KRPGKRTREK MKNRTH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the processing of the 27S pre-rRNA.
  • 基因功能参考文献：
    1. Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins. PMID: 30224479
    2. We further show that the primary tumors as well as metastasized lesions derived from EBV antigen-expressing cancer cells( EBNA3C or EBNA1 ) in nude mice model display EMT markers expression pattern PMID: 25501510
    3. EBP2 is a novel binding partner of c-Myc that regulates cell proliferation, and tumorigenesis via a positive feedback loop. PMID: 24481446
    4. attaches to yeast mitotic chromosomes in a cell cycle-dependent manner and causes EBNA1 to attach to the mitotic chromosomes and effect EBV plasmid segregation PMID: 12768013
    5. Data show that human EBNA1 binding protein 2 (hEBP2 is essential for the proliferation of human cells and that repression of hEBP2 severely decreases the ability of EBNA1 and EBV-based plasmids to bind mitotic chromosomes. PMID: 15923612
    6. RNA and protein levels of cyclin E1, a dominant oncoprotein, were elevated in the EBP2- enhanced green fluorescent protein stable clones. PMID: 18959818
    7. BXDC1 and EBNA1BP2 function in a dynamic scaffold for ribosome biogenesis. PMID: 19170763

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  • 亚细胞定位：
    Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.
  • 蛋白家族：
    EBP2 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 15531

    OMIM: 614443

    KEGG: hsa:10969

    STRING: 9606.ENSP00000407323

    UniGene: Hs.346868