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  4. Recombinant Human Proline-rich protein 13 (PRR13)

Recombinant Human Proline-rich protein 13 (PRR13)

  • 中文名称：
    人PRR13重组蛋白
  • 货号：
    CSB-YP882152HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PRR13重组蛋白
  • 货号：
    CSB-EP882152HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PRR13重组蛋白
  • 货号：
    CSB-EP882152HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PRR13重组蛋白
  • 货号：
    CSB-BP882152HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PRR13重组蛋白
  • 货号：
    CSB-MP882152HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PRR13
  • Uniprot No.：
  • 别名：
    PRR13; TXR1; BM-041Proline-rich protein 13; Taxane-resistance protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-148
  • 氨基酸序列
    MWNPNAGQPG PNPYPPNIGC PGGSNPAHPP PINPPFPPGP CPPPPGAPHG NPAFPPGGPP HPVPQPGYPG CQPLGPYPPP YPPPAPGIPP VNPLAPGMVG PAVIVDKKMQ KKMKKAHKKM HKHQKHHKYH KHGKHSSSSS SSSSSDSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.
  • 基因功能参考文献：
    1. These findings indicate that PRR13/THBS1 and TXN expression could be used for the prediction of resistance to treatment of epithelial ovarian cancer patients. PMID: 27779244
    2. In primary glioblastoma samples there was a high expression of TXR1 in cerebral tissue compared to control tissue. PMID: 28345125
    3. High Txr1 expression is associated with oxaliplatin resistance in gastric cancer. PMID: 24362794
    4. Low TXR1 mRNA levels were associated with higher response rate (RR), longer median progression-free survival (PFS) and median overall survival (mOS), whereas high TSP1 expression was correlated with higher RR, longer PFS and mOS PMID: 21157449
    5. Multivariate analysis showed that high TXR1/low TSP1 expression was an independent prognostic factor for decreased median time to tumor progression (TTP) and median overall survival (mOS). PMID: 19435835

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 24528

    OMIM: 610459

    KEGG: hsa:54458

    STRING: 9606.ENSP00000412064

    UniGene: Hs.744894