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  4. Recombinant Human Protein CREG1 (CREG1)

Recombinant Human Protein CREG1 (CREG1)

  • 货号：
    CSB-YP005957HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005957HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005957HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005957HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005957HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CREG1
  • Uniprot No.：
  • 别名：
    Cellular repressor of E1A stimulated genes 1; Cellular repressor of E1A-stimulated genes 1; CREG; CREG1; CREG1_HUMAN; Protein CREG1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    32-220
  • 氨基酸序列
    RGGRDHGDW DEASRLPPLP PREDAARVAR FVTHVSDWGA LATISTLEAV RGRPFADVLS LSDGPPGAGS GVPYFYLSPL QLSVSNLQEN PYATLTMTLA QTNFCKKHGF DPQSPLCVHI MLSGTVTKVN ETEMDIAKHS LFIRHPEMKT WPSSHNWFFA KLNITNIWVL DYFGGPKIVT PEEYYNVTVQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
  • 基因功能参考文献：
    1. Studies demonstrated that CREG may modulate homeostasis of vascular wall cells and inhibit inflammation of vascular tissue cells and macrophages. Mechanistically, CREG behaves like a typical soluble lysosomal protein that regulates the formation and maturation of lysosomes by modulating the small GTPase protein Rab7, to mediate autophagy in vascular vascular tissue cells. [review] PMID: 27784214
    2. These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer. PMID: 26722374
    3. Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation. PMID: 24896341
    4. The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway. PMID: 24018888
    5. CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells. PMID: 23580165
    6. miR-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation. PMID: 23518389
    7. Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. PMID: 23040447
    8. Upregulation of CREG expression induced HUVEC migration. PMID: 21939655
    9. Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition. PMID: 21263217
    10. Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R, modulating SMC phenotypic switching from contractile to proliferative. PMID: 21195083
    11. no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population PMID: 20951690
    12. CREG plays a key role in modulating VSMC apoptosis through the p38 and JNK signal transduction pathways, both in vitro and in s PMID: 20060003
    13. CREG plays a critical role in the inhibition of SMC migration, as well as maintaining SMCs in a mature phenotype PMID: 19769965
    14. putative flavin mononucleotide-binding pocket in CREG is sterically blocked by a loop and several key bulky residues PMID: 16344469
    15. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. PMID: 18267954
    16. We demonstrate that CREG is expressed in the vascular endothelium; data suggests that CREG differentially regulates the growth of the denuded artery wall and smooth vascular muscle cell. PMID: 18472385
    17. The expression of CREG improves cardiac functions and inhibits cardiac hypertrophy, inflammation and fibrosis through blocking MEK-ERK1/2-dependent signalling. PMID: 19413895

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    CREG family
  • 数据库链接：

    HGNC: 2351

    KEGG: hsa:8804

    STRING: 9606.ENSP00000359540

    UniGene: Hs.5710