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  4. Recombinant Human Protein FAM19A4 (FAM19A4)

Recombinant Human Protein FAM19A4 (FAM19A4)

  • 中文名称：
    人FAM19A4重组蛋白
  • 货号：
    CSB-YP836253HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FAM19A4重组蛋白
  • 货号：
    CSB-EP836253HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FAM19A4重组蛋白
  • 货号：
    CSB-EP836253HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FAM19A4重组蛋白
  • 货号：
    CSB-BP836253HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FAM19A4重组蛋白
  • 货号：
    CSB-MP836253HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FAM19A4
  • Uniprot No.：
  • 别名：
    TAFA4; FAM19A4; Chemokine-like protein TAFA-4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    36-140
  • 氨基酸序列
    SQHLR GHAGHHQIKQ GTCEVVAVHR CCNKNRIEER SQTVKCSCFP GQVAGTTRAQ PSCVEASIVI QKWWCHMNPC LEGEDCKVLP DYSGWSCSSG NKVKTTKVTR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.
  • 基因功能参考文献：
    1. Hypermethylation of FAM19A4/miR124-2 in the self-sample was tested in a quantitative methylation specific PCR and compared between lesions caused by HPV16/18 and other hrHPV genotypes. There were no differences in the percentages of positive FAM19A4/miR124-2 methylation assays between lesions caused by HPV16/18 (73.8% in CIN3+) or other hrHPV genotypes (66.7% in CIN3+) (p=0.538). PMID: 30219239
    2. With a similarly good clinical performance in both sample types, combined FAM19A4 methylation analysis and HPV16/18 genotyping provides a feasible triage strategy for hrHPV-positive women, with direct applicability on self-samples PMID: 27415009
    3. FAM19A4/mir124-2 methylation analysis performs equally well in HPV-positive lavage- and brush self-samples to identify women with CIN3+. In combination with HPV16/18 genotyping, significantly higher CIN3+ sensitivities are obtained, at decreased specificity. PMID: 26921784
    4. FAM19A4 is a novel ligand of formyl peptide receptor 1. PMID: 25109685
    5. among high risk HPV-positive women from an outpatient population aged >/= 30 years, methylation analysis of FAM19A4 is an attractive marker for the identification of women with high-grade cervical intraepithelial neoplasia and cervical cancer PMID: 26317579
    6. High methylation of FAM19A4 is associated with cervical carcinomas. PMID: 25281488

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    FAM19/TAFA family
  • 组织特异性：
    Expressed in brain. Expressed in LPS-stimulated monocytes and macrophages, especially in polarized M1.
  • 数据库链接：

    HGNC: 21591

    OMIM: 617498

    KEGG: hsa:151647

    STRING: 9606.ENSP00000295569

    UniGene: Hs.187873