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  4. Recombinant Human Protein FEV (FEV)

Recombinant Human Protein FEV (FEV)

  • 货号：
    CSB-YP858717HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP858717HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP858717HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP858717HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP858717HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FEV
  • Uniprot No.：
  • 别名：
    ETS-domain transcription factor; FEV (ETS oncogene family); FEV; FEV ETS transcription factor; FEV_HUMAN; Fifth Ewing sarcoma variant; Fifth Ewing variant protein; HSRNAFEV; mPet1; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1; Protein FEV
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-238
  • 氨基酸序列
    MRQSGASQPL LINMYLPDPV GDGLFKDGKN PSWGPLSPAV QKGSGQIQLW QFLLELLADR ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMSKVHGK RYAYRFDFQG LAQACQPPPA HAHAAAAAAA AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL MAASAGVAPA GFSYWPGPGP AATAAAATAA LYPSPSLQPP PGPFGAVAAA SHLGGHYH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
  • 基因功能参考文献：
    1. This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents. PMID: 28846959
    2. identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin PMID: 27807368
    3. Genetic variation in FEV1 was associated with serum 25-Hydroxyvitamin D status. PMID: 26122139
    4. novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation PMID: 24100022
    5. Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development. PMID: 23591790
    6. our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders PMID: 20480378
    7. FEV identifies serotonin-producing cells in normal and neoplastic small intestine. PMID: 20048018
    8. Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. PMID: 19707175
    9. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. PMID: 12761502
    10. We showed that fev is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT transporter (sert) and tryptophan hydroxylase (tph), two markers of the 5-HT neurotransmitter system. PMID: 15003288
    11. Analysis of transgene expression in Pet-1 null mice indicates that Pet-1 is required to maintain the activity of the Pet-1 enhancer region in a subset of serotonin (5-HT) neurons. PMID: 15758173
    12. Variation in FEV gene observed exclusively in a subset of African American sudden infant death syndrome cases may help explain the observed abnormalities of this system in some SIDS cases and the ethnic disparity. PMID: 17597646

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  • 相关疾病：
    Sudden infant death syndrome (SIDS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
  • 数据库链接：

    HGNC: 18562

    OMIM: 272120

    KEGG: hsa:54738

    STRING: 9606.ENSP00000295727

    UniGene: Hs.234759