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FEV Antibody

  • 货号：
    CSB-PA858717LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate, Rat brain tissue
      All lanes: FEV antibody at 5.9µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
    • IHC image of CSB-PA858717LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA858717LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA858717LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FEV Polyclonal antibody
  • Uniprot No.：
    Q99581
  • 基因名：
    FEV
  • 别名：
    ETS-domain transcription factor antibody; FEV (ETS oncogene family) antibody; FEV antibody; FEV ETS transcription factor antibody; FEV_HUMAN antibody; Fifth Ewing sarcoma variant antibody; Fifth Ewing variant protein antibody; HSRNAFEV antibody; mPet1 antibody; PC12 ETS domain-containing transcription factor 1 antibody; PC12 ETS factor 1 antibody; Pet-1 antibody; Protein FEV antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Protein FEV protein (1-97AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FEV Antibody (CSB-PA858717LA01HU)，的标记方式是Non-conjugated。对于FEV Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA858717LB01HU FEV Antibody, HRP conjugated ELISA
    FITC CSB-PA858717LC01HU FEV Antibody, FITC conjugated
    Biotin CSB-PA858717LD01HU FEV Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
  • 基因功能参考文献：
    1. This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents. PMID: 28846959
    2. identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin PMID: 27807368
    3. Genetic variation in FEV1 was associated with serum 25-Hydroxyvitamin D status. PMID: 26122139
    4. novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation PMID: 24100022
    5. Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development. PMID: 23591790
    6. our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders PMID: 20480378
    7. FEV identifies serotonin-producing cells in normal and neoplastic small intestine. PMID: 20048018
    8. Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. PMID: 19707175
    9. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. PMID: 12761502
    10. We showed that fev is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT transporter (sert) and tryptophan hydroxylase (tph), two markers of the 5-HT neurotransmitter system. PMID: 15003288
    11. Analysis of transgene expression in Pet-1 null mice indicates that Pet-1 is required to maintain the activity of the Pet-1 enhancer region in a subset of serotonin (5-HT) neurons. PMID: 15758173
    12. Variation in FEV gene observed exclusively in a subset of African American sudden infant death syndrome cases may help explain the observed abnormalities of this system in some SIDS cases and the ethnic disparity. PMID: 17597646

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  • 相关疾病：
    Sudden infant death syndrome (SIDS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
  • 数据库链接：

    HGNC: 18562

    OMIM: 272120

    KEGG: hsa:54738

    STRING: 9606.ENSP00000295727

    UniGene: Hs.234759