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  4. Recombinant Human Protein NDRG2 (NDRG2)

Recombinant Human Protein NDRG2 (NDRG2)

  • 货号：
    CSB-YP891788HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP891788HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP891788HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP891788HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP891788HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NDRG2
  • Uniprot No.：
  • 别名：
    Antidepressant related protein ADRG123; Cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N myc downstream regulated gene 2; N myc downstream regulator 2; NDR1 related protein NDR2; NDRG 2; NDRG family member 2; NDRG1 related protein; NDRG2; NDRG2_HUMAN; Protein NDRG2; Protein Syld709613; SYLD; Syld709613 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-371
  • 氨基酸序列
    AELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV TFTVYGTPKP KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV DAPGMEEGAP VFPLGYQYPS LDQLADMIPC VLQYLNFSTI IGVGVGAGAY ILARYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPEMILGH LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR RDLNFERGGD ITLRCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS QSSESGTLSS GPPGHTMEVS C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
  • 基因功能参考文献：
    1. NDRG2 knockdown promotes renal fibrosis through its effect on the protein and mRNA expression of epithelial-mesenchymal transition markers. PMID: 28646304
    2. Data show that Sentrin/SUMO specific protease (SENP2) interacts with N-myc downstream regulated gene 2 (NDRG2) and mediates the de-SUMOylation process of NDRG2. PMID: 29060933
    3. Down-regulation of NDRG2 promotes cancer cell proliferation and neoplasm invasion through regulation by microRNA-454. PMID: 29080452
    4. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death. PMID: 28670853
    5. Lower expression of KLF4 and NDRG2 in colorectal cancer patients was correlated with poor overall survival. Thus, KLF4 inhibited the proliferation of colorectal cancer cells dependent on NDRG2 signaling, which provides a novel strategy for therapy and early diagnosis of colorectal cancer. PMID: 28656310
    6. NDRG2 could be a potential independent diagnostic biomarker for bladder cancer. PMID: 28953854
    7. The different NDRG2 promoter methylation and expression levels in pituitary adenoma samples showed tumor heterogeneity and indicates a potential role of this gene in pituitary adenoma pathogenesis. PMID: 28390436
    8. NDRG2 expression decreased in adriamycin resistance breast cancer cells. NDRG2 can promote adriamycin sensitivity by inhibiting proliferation, enhancing cellular damage responses, and promoting apoptosis in a p53-dependent manner. PMID: 28423695
    9. s investigate the clinical and pathological role of NDRG2 in human malignant tumors. The absence of NDRG2 expression is associated with oncogenic properties through the loss of its role as a tumor suppressor; NDRG2 overexpression inhibits proliferation, adhesion, and invasion, whereas its expression is low or undetectable in various cancers. [Review] PMID: 27113371
    10. These findings indicate that SUMOylation of NDRG2 is necessary for its tumor suppressor function in lung adenocarcinoma and that RNF4 increases the efficiency of this process. PMID: 27072586
    11. NDRG2 is a novel ERS-responsive protein and acts as PERK co-factor to facilitate PERK branch, thereby contributing to ERS-induced apoptosis. PMID: 28948615
    12. Our results show how NDRG2 expression serves as a critical determinant of the invasive and metastatic capacity of oral squamous cell carcinoma (OSCC) PMID: 28209617
    13. putative tumor suppressive function of NDRG2 may be confined to luminal- and basal B-type breast cancers PMID: 27400234
    14. Overexpression of NDRG2 can inhibit the proliferation. PMID: 28031114
    15. present results suggest that hypermethylation in promoter around exon 2 is functioning as essential factors of NDRG2 silencing in gastrointestinal cancers PMID: 28093228
    16. NDRG2 overexpression significantly reduced hepatoma cell proliferation and enhanced cell apoptosis under glucose limitation. Moreover, NDRG2 overexpression aggravated energy imbalance and oxidative stress by decreasing the intracellular ATP and NADPH generation and increasing ROS levels. PMID: 28069379
    17. The methylation status of the NDRG2 promoter in PBMCs is a potential noninvasive biomarker to predict the severity of liver fibrosis. PMID: 28202850
    18. Data show that downregulation of NDRG2 may play an important role in advanced hepatoblastomas. PMID: 26646663
    19. Study shows that NDRG2 was significantly down-regulated in glioblastomas (GBM) and seems to play a role in GBM prognosis. The low expression of NDRG2 at the mRNA level leads to a longer progression-free survival independent of methylation status. PMID: 26976975
    20. Stuidies indicate the potential of N-myc downstream-regulated gene 2 (NDRG2) as a therapeutic target for cancer. PMID: 26506239
    21. NDRG2 overexpression enhanced sodium/iodide symporter level in thyroid tumor cells and increased their iodine uptake in vitro. PMID: 26802650
    22. Epigenetic silencing of NDRG2 promotes colorectal cancer proliferation and invasion. PMID: 26250123
    23. miR-301a/b-NDRG2 might be an important axis modulating autophagy and viability of prostate cancer cells under hypoxia. PMID: 26813459
    24. Loss of NDRG2 induced the expression of matrix metalloproteinase-19 (MMP-19), which regulated the expression of Slug at the transcriptional level in the epithelial-mesenchymal transition of gallbladder carcinoma cells. PMID: 26292259
    25. The forced expression of NDRG2 in ATL cells down-regulates not only the canonical pathway by inhibiting AKT signaling but also the non-canonical pathway by inducing NF-kappaB-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A PMID: 26269411
    26. NDRG2 functions as an essential regulator in glycolysis and glutaminolysis via repression of c-Myc, and acts as a suppressor of carcinogenesis. PMID: 26317652
    27. This review summarizes the distribution and subcellular localization of NDRG2 in brain tissues, highlights the physiological actions of NDRG2 in the nervous system, and discusses the roles of NDRG2 during the occurrence of nervous system disease. [review] PMID: 26341979
    28. NDRG2 suppresses the proliferation of human bladder cancer cells via induction of oncosis. PMID: 26239274
    29. s found that H. pylori silenced Ndrg2 by activating the NF-kappaB pathway and up-regulating DNMT3b, promoting gastric cancer progression. Findings uncover a previously unrecognized role for H. pylori infection in gastric cancer. PMID: 25823664
    30. NDRG2 acts as a negative regulator downstream of androgen receptor and inhibits the growth of androgen-dependent and castration-resistant prostate cancer. PMID: 25756511
    31. The downregulation of NDRG2 combined with the upregulation of CD24 may play a synergistic role in the occurrence and progression of hepatocellular carcinoma. PMID: 25338637
    32. NDRG2 was negatively correlated with Bcl-2 in gastric cancer tissues. PMID: 25854572
    33. NDRG2 can significantly inhibit the proliferation of OS-RC-2 cells in vitro and its protein is specifically expressed in the mitochondrion PMID: 24839115
    34. these data show that the inhibition of NF-kappaB signaling by NDRG2 expression is able to suppress cell migration and invasion through the down-regulation of COX-2 expression. PMID: 25256221
    35. NDRG2/gp130/STAT3 pathway can mediate the antimetastatic effects of Dp44mT in hepatocellular carcinoma. PMID: 25261367
    36. findings show NDRG2 expression is downregulated in glioma and level of NDRG2 expression negatively correlates with glioma grade;findings also indicate NDRG2 downregulation may be due to aberrant methylation of NDRG2 promoter region and subsequent transcriptional inactivation PMID: 24840052
    37. Data suggest targeting the actions of N-myc downstream-regulated gene 2 (NDRG2) in cell glucose-dependent energy delivery may provide a strategy for therapeutic intervention in breast carcinoma. PMID: 24636131
    38. Data show the expression of N-myc downstream-regulated gene 2 (NDRG2) is frequently downregulated in adult T-cell leukaemia-lymphoma, resulting in enhanced phosphorylation of PTEN and activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. PMID: 24569712
    39. the inhibition of STAT3 signaling by NDRG2 suppresses EMT progression of EMT via the down-regulation of Snail expression PMID: 25153349
    40. Taken together, these data indicate that NDRG2 inhibits the proliferation of neuroblastoma cells partially through suppression of cysteine-rich protein 61. PMID: 24528032
    41. NDRG2 overexpression can inhibit tumor growth and invasion in vitro. PMID: 24146910
    42. NDRG2 expression with cell density preceded E-cadherin expression, and the regulation of Snail activity by GSK-3beta was also related to this process. PMID: 23900729
    43. the expression of NDRG2 is an independent prognostic factor in pancreatic cancer. PMID: 24134849
    44. The present experiments demonstrated that NDRG2 may be a diagnostic and prognostic marker in patients with oesophageal squamous cell carcinoma PMID: 23800335
    45. NDRG2 gene expression can be induced by hyperthermia and is correlated with neoplasm invasion in hepatocellular carcinoma. PMID: 23630579
    46. findings bring insight to the roles of NDRG2 in ischemic-hypoxic injury and provide potential targets for future clinical therapies on stroke PMID: 23451161
    47. NDRG2 gene expression is down-regulated in atypical and recurrent meningiomas. PMID: 20607352
    48. These data showed that NDRG2 may play an important role in human lung cancer tumourigenesis PMID: 23307246
    49. Our results suggest that the decreased expression of NDRG2 or the increased expression of CD24 is an important feature of lung adenocarcinoma. PMID: 22528516
    50. NDRG2 could suppress clear cell renal cell carcinoma cell invasion through regulating MMP-9 expression and activity. PMID: 22692967

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone.
  • 蛋白家族：
    NDRG family
  • 组织特异性：
    Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. E
  • 数据库链接：

    HGNC: 14460

    OMIM: 605272

    KEGG: hsa:57447

    STRING: 9606.ENSP00000298687

    UniGene: Hs.525205