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  4. Recombinant Human Protein PAT1 homolog 1 (PATL1)

Recombinant Human Protein PAT1 homolog 1 (PATL1)

  • 货号：
    CSB-YP801224HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP801224HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP801224HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP801224HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PATL1
  • Uniprot No.：
  • 别名：
    hPat1b; OK/KNS-cl.5; PAT1-like protein 1; Pat1b; PATL1; PATL1_HUMAN; protein associated with topoisomerase II homolog 1 ; Protein PAT1 homolog 1; Protein PAT1 homolog b
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-770
  • 氨基酸序列
    MFRYESLEDC PLDEDEDAFQ GLGEEDEEID QFNDDTFGSG AVDDDWQEAH ERLAELEEKL PVAVNEQTGN GERDEMDLLG DHEENLAERL SKMVIENELE DPAIMRAVQT RPVLQPQPGS LNSSIWDGSE VLRRIRGPLL AQEMPTVSVL EYALPQRPPQ GPEDDRDLSE RALPRRSTSP IIGSPPVRAV PIGTPPKQMA VPSFTQQILC PKPVHVRPPM PPRYPAPYGE RMSPNQLCSV PNSSLLGHPF PPSVPPVLSP LQRAQLLGGA QLQPGRMSPS QFARVPGFVG SPLAAMNPKL LQGRVGQMLP PAPGFRAFFS APPSATPPPQ QHPPGPGPHL QNLRSQAPMF RPDTTHLHPQ HRRLLHQRQQ QNRSQHRNLN GAGDRGSHRS SHQDHLRKDP YANLMLQREK DWVSKIQMMQ LQSTDPYLDD FYYQNYFEKL EKLSAAEEIQ GDGPKKERTK LITPQVAKLE HAYKPVQFEG SLGKLTVSSV NNPRKMIDAV VTSRSEDDET KEKQVRDKRR KTLVIIEKTY SLLLDVEDYE RRYLLSLEEE RPALMDDRKH KICSMYDNLR GKLPGQERPS DDHFVQIMCI RKGKRMVARI LPFLSTEQAA DILMTTARNL PFLIKKDAQD EVLPCLLSPF SLLLYHLPSV SITSLLRQLM NLPQSAATPA LSNPHLTAVL QNKFGLSLLL ILLSRGEDLQ SSDPATESTQ NNQWTEVMFM ATRELLRIPQ AALAKPISIP TNLVSLFSRY VDRQKLNLLE TKLQLVQGIR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly.; (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV).
  • 基因功能参考文献：
    1. evidence for a nuclear complex of Pat1b with the Lsm2-8 heptamer, which binds to the spliceosomal U6 small nuclear RNA (snRNA). PMID: 28768202
    2. data indicate that P-body assembly occurs in a step-wise manner, where Rck participates in the initial suppression of mRNA translation, whereas Pat1b in a second step triggers P-body assembly and promotes mRNA decapping PMID: 23535175
    3. The PATL1 as well as DCP1A, a well-known P-body marker, co-localized with a subset of ALG-2. PMID: 22437941
    4. Pat1b participates in several RNA-related nuclear processes in addition to its multiple regulatory roles in the cytoplasm PMID: 22090346
    5. Pat1b represses gene expression by inducing deadenylation of the mRNAs. PMID: 20852261
    6. hPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion. PMID: 20826699
    7. By tethering Pat1b to a reporter mRNA, the study provides evidence that Pat1b is also functionally linked to both deadenylation and decapping. PMID: 20584987
    8. Data show that PatL1 is essential for the interaction with mRNA decapping factors (i.e. DCP2, EDC4 and LSm1-7), whereas the P-rich region and Mid domain have distinct functions in modulating these interactions. PMID: 20543818
    9. The identification of two human PAT1 genes is described and one of them, PATL1, codes for an open reading frame with similar features as the yeast PAT1. PMID: 17936923

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  • 亚细胞定位：
    Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle.
  • 蛋白家族：
    PAT1 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 26721

    OMIM: 614660

    KEGG: hsa:219988

    STRING: 9606.ENSP00000300146

    UniGene: Hs.591960