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  4. Recombinant Human Protein S100-A3 (S100A3)

Recombinant Human Protein S100-A3 (S100A3)

  • 中文名称：
    人S100A3重组蛋白
  • 货号：
    CSB-EP020631HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    S100A3
  • Uniprot No.：
  • 别名：
    Protein S 100E; Protein S-100E; Protein S100 A3; Protein S100-A3; S100 calcium binding protein A3; S100 calcium-binding protein A3; S100a3; S100E; S10A3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    38.6kDa
  • 表达区域：
    1-101aa
  • 氨基酸序列
    ARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELATWTPTEFRECDYNKFMSVLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
  • 基因功能参考文献：
    1. S100A3 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. One disulfide bridge is between Cys30 in the N-terminal pseudo-EF-hand and Cys68 in the C-terminal EF-hand (SS1), and another disulfide bridge attaches Cys99 in the C-terminal coil structure to Cys81 in helix IV (SS2). PMID: 21377473
    3. crystal structure of S100A3 at 1.7-A resolution PMID: 12045193
    4. structure was solved by MIRAS phasing PMID: 12136135
    5. Purification and characterization of the S100A3 protein from human hair cuticles. PMID: 12470658
    6. cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3) PMID: 18083705

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    S-100 family
  • 组织特异性：
    Skin specific, specifically expressed at the inner endocuticle of hair fibers.
  • 数据库链接：

    HGNC: 10493

    OMIM: 176992

    KEGG: hsa:6274

    STRING: 9606.ENSP00000357701

    UniGene: Hs.557609