Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Protein S100-A7 (S100A7)

Recombinant Human Protein S100-A7 (S100A7)

  • 货号：
    CSB-YP020635HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP020635HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP020635HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP020635HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP020635HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    HID 5; Protein S100 A7; Protein S100-A7; PSOR 1; PSOR1; Psoriasin 1; Psoriasin; Psoriasin1; S100 Calcium binding protein A7; S100 calcium-binding protein A7; S100A7; S100A7c; S10A7_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-101
  • 氨基酸序列
    SNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Higher levels of psoriasin expression were significantly associated a lack of response to neoadjuvant chemotherapy in patients with gastric cancer (GC). Psoriasin overexpression tended to decrease the sensitivity of GC cells to cisplatin, potentially by inhibiting apoptosis or increasing the S-phase population. PMID: 29956751
    2. Study results suggest that OLFM4, LY6D and S100A7 immunoreactivity are associated with an aggressive phenotype of estrogen receptor (ER)-positive breast carcinoma, and these are potent markers for distant metastasis of ER-positive breast cancer patients. PMID: 30137688
    3. As a regulator of epithelial ovarian cancer (EOC) cell proliferation, metastasis, and chemoresistance, S100A7 represents a potential prognostic biomarker for EOC as well as a treatment target. Because miR-330-5p functions as an inhibitor of EOC cell growth and S100A7 expression, it promises to improve EOC outcomes. PMID: 29485916
    4. Data reveal a crucial role for S100A7 in regulating cell migration, invasion, metastasis and EMT of cervical cancer. PMID: 28212564
    5. Study demonstrates for the first time that S100A7 not only functions as a facilitator of adenous-squamous carcinoma phenotypic transition in lung cancer cells but also that its expression is differentially regulated by the Hippo-YAP pathway. PMID: 28177901
    6. Findings demonstrate for the first time that S100A7 is repressed by YAP via the Hippo pathway. PMID: 27203549
    7. In this paper, we reviewed the emerging roles of S100A7 in the pathogenesis of psoriasis. In particular, we focus on the psoriatic cytokine network where S100A7 is involved. Finally, we discuss the possible use of S100A7 as therapeutic target in psoriasis. PMID: 26872860
    8. The promigratory function of S100A7 on tumor cells was confirmed in A431 cells where neutralizing monoclonal antibodies were able to block this effect. PMID: 28825725
    9. a set of IL-17A-regulated genes in keratinocytes, which recapitulate typical psoriasis genes exemplified by DEFB4A, S100A7, IL19 and CSF3, based on the differences in the expression profiles of cells stimulated with six cytokines versus cells stimulated with only five cytokines lacking IL-17A. PMID: 26944069
    10. Psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis. PMID: 27958610
    11. only S100A7ox exhibits antibacterial activity against select bacterial species. Metal substitution experiments suggest that the disulfide bonds in S100A7 may enhance metal sequestration by the His3Asp sites and thereby confer growth inhibitory properties to S100A7ox. PMID: 28976190
    12. A significant increase of salivary psoriasin was observed in Systemic sclerosis patients when compared with other healthy and pathological controls. PMID: 27608975
    13. our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis. PMID: 28060905
    14. higher expression of Psoriasin was associated with local invasion in pancreatic cancers. Psoriasin expression is associated with pancreatic cancer cell growth, migration, cell-matrix adhesion, and invasion via regulation of MMPs PMID: 28393239
    15. S100A7 induction by the Hippo-YAP pathway in cervical and glossopharyngeal squamous cell carcinoma has been described. PMID: 27907036
    16. The expression of inflammatory markers in the conjunctiva of trachomatous trichiasis patients were studied; CTGF, S100A7, and IL-1beta were all increased. PMID: 27249027
    17. S100 calcium-binding protein A7 (S100A7) overexpression was demonstrated in the plaques of patients with psoriasis vulgaris with joint inflammation, compared with those without joint involvement. PMID: 27573000
    18. rs3014837 polymorphism associated with calcium level in serum of psoriasis patients PMID: 26173840
    19. The presence of S100A7 in the Fallopian tube and its localization at the apical surface of epithelial cells PMID: 24152708
    20. overexpression of S100A7 in A431 skin squamous carcinoma cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3 and caspase-14 PMID: 25651379
    21. S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation of squamous cell carcinomas. PMID: 26053695
    22. The distinct modulations of the NF-kappaB - miR-29b - p53 pathway make S100A7 an oncogene. PMID: 25622979
    23. S100A7 also promotes secretion of IL-6 and IL-8. PMID: 24671027
    24. The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts PMID: 25502330
    25. decreased expression in nasal epithelia of allergic rhinitis patients PMID: 25514480
    26. Our present results suggest that S100A7 level is a promising tool for diagnosis of lung squamous cell carcinoma. Knockdown of S100A7 suppresses lung cancer growth PMID: 25550886
    27. present a novel signalling mechanism by which IL-17A can induce Egr-1-dependent psoriasin expression via the ERK pathway in keratinocytes PMID: 25256120
    28. found that RAGE/S100A7 conditioned the tumor microenvironment by driving the recruitment of MMP9-positive tumor-associated macrophages PMID: 25572331
    29. The antimicrobial peptide psoriasin has immunoregulatory activities and is involved in skin innate immunity. PMID: 24842328
    30. Data indicate that aberrant expression of psoriasin is implicated in prostate cancer (CaP). PMID: 22694938
    31. visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin. PMID: 23499548
    32. S100A7 overexpression is associated with high risk of malignant transformation in oral dysplasia. PMID: 24122701
    33. S100A7 enhances metastasis in estrogen receptor alpha-negative breast cancer cells through regulation of actin cytoskeleton and MMP-9 secretion. PMID: 23535840
    34. High S100A7 enhances invasion of breast cancer through activation of nuclear factor-kappaB signaling. PMID: 23618129
    35. Levels of psoriasin, RNase 7 and hBD-3 expression - assessed by immunohistochemistry - varied between different body localisations. PMID: 23614747
    36. Psoriasin plays crucial roles in regulating the growth and invasion of lung cancer cells. PMID: 23228205
    37. expression of psoriasin is linked to the luminal differentiation marker CD24 in mammary epithelial cells. Psoriasin had a role in the shift towards a differentiated CD24(+) phenotype, suggesting a role in the differentiation of mammary epithelial cells. PMID: 23300877
    38. Each S100A7 isoform is involved in critical phases of the breast cancer growth and progression PMID: 22641350
    39. Psoriasin is a novel biomarker for, and the first to confirm the link between obesity and psoriasis. PMID: 23151615
    40. Increased S100A7 expression was associated with trachomatous conjunctival scarring and may be linked to the pathophysiology of recurrent trachomatous trichiasis. PMID: 23285311
    41. Psoriasin may play a role in the pathogenesis of mycosis fungoides by stimulating chemotaxis of CD4+ T lymphocytes. PMID: 22126777
    42. Expression of psoriasin appears to be reduced in CFBE410-negative cells compared to 16HBE14o- cells; its expression treatment-wise is modified by exposure to pro-inflammatory cytokines. PMID: 22772316
    43. Letter: Report IL-36-mediated psoriasin and LL-37 production in keratinocytes via MAPK/NFkappaaB pathway. PMID: 22901663
    44. Psoriasin (S100A7) promotes migration of a squamous carcinoma cell line PMID: 22795619
    45. psoriasin expression in mammary epithelial cells leads to increased endothelial cell proliferation in a paracrine manner through the receptor for advanced glycation end products. PMID: 22189627
    46. report the presence of S100A7 in human sperm and of a homologous protein in pig, with similar localisations PMID: 22220760
    47. The study showed an epithelial expression and excretion of S100A7 in the nose after microbial stimulation. The levels were diminished in rhinitis patients and in the presence of an allergic cytokine milieu. PMID: 22230654
    48. Recent studies point to an important role of psoriasin as an antimicrobial and immunomodulatory protein in skin and other epithelia. PMID: 21501383
    49. Data show that hS100A7 and mS100a7a15 overexpression induce proliferation and expression of inflammatory cytokines/chemokines. PMID: 22158945
    50. Tumor-suppressive effects of psoriasin (S100A7) are mediated through the beta-catenin/T cell factor 4 protein pathway in estrogen receptor-positive breast cancer cells. PMID: 22016394

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Secreted. Note=Secreted by a non-classical secretory pathway.
  • 蛋白家族：
    S-100 family
  • 组织特异性：
    Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.
  • 数据库链接：

    HGNC: 10497

    OMIM: 600353

    KEGG: hsa:6278

    STRING: 9606.ENSP00000357711

    UniGene: Hs.112408