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  4. Recombinant Human Protein tyrosine phosphatase type IVA 1 (PTP4A1)

Recombinant Human Protein tyrosine phosphatase type IVA 1 (PTP4A1)

  • 中文名称：
    人PTP4A1重组蛋白
  • 货号：
    CSB-YP846294HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PTP4A1重组蛋白
  • 货号：
    CSB-EP846294HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PTP4A1重组蛋白
  • 货号：
    CSB-EP846294HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PTP4A1重组蛋白
  • 货号：
    CSB-BP846294HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PTP4A1重组蛋白
  • 货号：
    CSB-MP846294HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PTP4A1
  • Uniprot No.：
  • 别名：
    HH 72; HH72; Hypothetical protein DKFZp779M0721 ; Phosphatase of regenerating liver 1; PRL 1; PRL-1; PRL1; Protein tyrosine phosphatase PTPCAAX1; Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase type IVA member 1; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; Protein-tyrosine phosphatase; type 4A; 1; PTP(CAAXI); Ptp4a1; PTPCAAX1; TP4A1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-170
  • 氨基酸序列
    MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
  • 基因功能参考文献：
    1. PTP4A1 is a direct downstream target of miR-1271 in the hepatocellular carcinoma. PMID: 29345291
    2. PTP4A1 is highly expressed in fibroblasts from patients with systemic sclerosis and enhances pro-fibrotic TGFbeta signaling in these cells. PMID: 29057934
    3. PTP4A1 was overexpressed in ICC and played an important role in the progression and metastasis of ICC. The functional role of PTP4A1 was assumed to be acted by activation PI3K/AKT signaling and promoting the EMT process through two pivotal transcriptional factors Zeb1 and Snail. PMID: 27655691
    4. Results showed that SIAH1 and PTP4A1 expression was regulated by mir-944 in breast cancer cells. miR-944 binds directly the 3 UTR of their promotor region. PMID: 27377268
    5. miR-601 inhibits growth and invasion of breast cancer cells by targeting PTP4A1. PMID: 27044835
    6. Data indicate that protein-tyrosine-phosphatase of regenerating liver 1 (PRL1) gene was expressed much more highly in prostate cancer (PCa) than in nonneoplastic prostate samples. PMID: 24968948
    7. Upregulation of PRL-1 expression is inversely correlated with miR-26a in primary cervical cancer tissues. PMID: 24939702
    8. Data highlight the oncogenic function of PRL-1 in HCC invasion and metastasis. PMID: 25003523
    9. We confirmed with our previous findings that PTP4A1-PHF3-EYS variants were significantly associated with alcohol dependence. PMID: 24961364
    10. PTP4A1-PHF3-EYS variants were associated with alcohol dependence. PMID: 23324950
    11. Results suggest that TRP32 maintains the reduced state of PRL and thus regulates the biological function of PRL. PMID: 23362275
    12. Studies indicate that PRL-1 and PRL-2 and PRL-3 are oncogenes and belong to the few phosphatases that lead to the development of cancer. PMID: 22413991
    13. upregulation of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma PMID: 22484636
    14. Data conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder. PMID: 22096494
    15. PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation PMID: 22009749
    16. Increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion. PMID: 19199380
    17. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics PMID: 12235145
    18. PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase PMID: 14643450
    19. PRL-1 phosphatase has a trimeric structure which reveals an active enzyme conformation and regulation mechanisms PMID: 15571731
    20. PRL-1 mRNA expression was not significantly higher in malignant compared to benign breast tissue. PMID: 16832410
    21. PRL-1 expression levels varied considerably both between tissue types and cell type examined. Widespread expression of PRL-1 in multiple organ systems suggests an important functional role for these enzymes in normal tissue homeostasis. PMID: 16957164
    22. Colonic adenocarcinoma cells have the ability to produce PTP4A1, PTP4a2, and PTP4A3, which may relate to the lymph node metastasis of colonic adenocarcinoma. PMID: 17440740
    23. that trimerization may be a general property for all PRL enzymes, and that PRL1 trimer formation is essential for the PRL1-mediated cell growth and migration. PMID: 17656357
    24. PRL-1 and PRL-3 mRNAs may be involved in and used to predict the metastasis of esophageal squamous cell carcinoma. Possibility of using PRL-1 and PRL-3 as therapeutical target. PMID: 18684031
    25. the new oncogenic p53 target, PRL-1, may contribute to tumor development by the downregulation of p53 by a negative feedback mechanism. PMID: 18997816
    26. phosphatase of regenerating liver activity is controlled by the redox environment and its C-terminal residues PMID: 19341304

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus.
  • 蛋白家族：
    Protein-tyrosine phosphatase family
  • 组织特异性：
    Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
  • 数据库链接：

    HGNC: 9634

    OMIM: 601585

    KEGG: hsa:7803

    STRING: 9606.ENSP00000359685

    UniGene: Hs.227777