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  4. Recombinant Human RBPJ-interacting and tubulin-associated protein (RITA)

Recombinant Human RBPJ-interacting and tubulin-associated protein (RITA)

  • 中文名称：
    人RITA1重组蛋白
  • 货号：
    CSB-YP842696HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RITA1重组蛋白
  • 货号：
    CSB-EP842696HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RITA1重组蛋白
  • 货号：
    CSB-EP842696HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RITA1重组蛋白
  • 货号：
    CSB-BP842696HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RITA1重组蛋白
  • 货号：
    CSB-MP842696HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RITA1
  • Uniprot No.：
  • 别名：
    RITA1; C12orf52; RITA; PSEC0043; RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-269
  • 氨基酸序列
    MKTPVELAVS GMQTLGLQHR CRGGYRVKAR TSYVDETLFG SPAGTRPTPP DFDPPWVEKA NRTRGVGKEA SKALGAKGSC ETTPSRGSTP TLTPRKKNKY RPISHTPSYC DESLFGSRSE GASFGAPRMA KGDAAKLRAL LWTPPPTPRG SHSPRPREAP LRAIHPAGPS KTEPGPAADS QKLSMGGLHS SRPLKRGLSH SLTHLNVPST GHPATSAPHT NGPQDLRPST SGVTFRSPLV TSRARSVSIS VPSTPRRGGA TQKPKPPWK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
  • 基因功能参考文献：
    1. structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J. PMID: 28487372
    2. human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly PMID: 25588307
    3. RITA might suppress tumor growth and induce apoptosis in hepatocellular carcinoma. PMID: 24308154
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.
  • 蛋白家族：
    RITA family
  • 数据库链接：

    HGNC: 25925

    KEGG: hsa:84934

    STRING: 9606.ENSP00000410395

    UniGene: Hs.524762