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  4. Recombinant Human RNA-binding protein 38 (RBM38)

Recombinant Human RNA-binding protein 38 (RBM38)

  • 中文名称：
    人RBM38重组蛋白
  • 货号：
    CSB-YP880939HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RBM38重组蛋白
  • 货号：
    CSB-EP880939HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RBM38重组蛋白
  • 货号：
    CSB-EP880939HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RBM38重组蛋白
  • 货号：
    CSB-BP880939HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RBM38重组蛋白
  • 货号：
    CSB-MP880939HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RBM38
  • Uniprot No.：
  • 别名：
    CLL associated antigen KW 5 ; CLL-associated antigen KW-5; HSRNASEB; RBM38; RBM38_HUMAN; RNA binding motif protein 38; RNA binding protein 38 ; RNA binding region (RNP1; RRM) containing 1 ; RNA binding region containing protein 1 ; RNA-binding motif protein 38; RNA-binding protein 38; RNA-binding region-containing protein 1; RNPC1 ; SEB4; SEB4B; SEB4D; ssDNA binding protein SEB4 ; ssDNA-binding protein SEB4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-239
  • 氨基酸序列
    MLLQPAPCAP SAGFPRPLAA PGAMHGSQKD TTFTKIFVGG LPYHTTDASL RKYFEGFGDI EEAVVITDRQ TGKSRGYGFV TMADRAAAER ACKDPNPIID GRKANVNLAY LGAKPRSLQT GFAIGVQQLH PTLIQRTYGL TPHYIYPPAI VQPSVVIPAA PVPSLSSPYI EYTPASPAYA QYPPATYDQY PYAASPATAA SFVGYSYPAA VPQALSAAAP AGTTFVQYQA PQLQPDRMQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.; (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.
  • 基因功能参考文献：
    1. Our findings suggested that RBM38 may be a core contributor in stabilizing the p53-mdm2 loop function to prevent hepatocellular carcinoma (HCC) and a potential novel target to provide a therapeutic strategy for HCC by inhibiting mdm2 and rescuing p53 from inactivation PMID: 30176896
    2. Investigated RNA-binding region-containing protein 1 (RNPC1) action on signal pathways and disease progression in lung cancer samples and cells. Found RNPC1 acts to downregulate the miR-181a mediated inhibition of cancer susceptibility 2 (CASC2) expression in lung cancer. Results show RNPC1 inhibits NSCLC progression in a miR-181a/CASC2 axis-dependent manner. PMID: 29288351
    3. Results showed that the expressions of RBM38 and PTEN was positively correlated in human breast cancer tissues. RBM38 upregulated PTEN expression and activity in breast cancer cells through its direct binding to PTEN mRNA 3'UTR enhancing its stability. These data implied that RBM38 acted as a tumor suppressor partly by enhancing PTEN expression. PMID: 29052531
    4. Taken together, these results suggest that the 11-kDa protein facilitates B19V DNA replication and that RBM38 is an essential host factor for B19V pre-mRNA splicing and for the expression of the 11-kDa protein. PMID: 29437973
    5. Results report that RBM38 mediates direct inhibition of c-Myc expression, which in turn suppresses RBM38 expression. Thus, it can be concluded that RBM38 and c-Myc form a unique mutually antagonistic RBM38-c-Myc loop in breast cancer. PMID: 28399911
    6. Here we uncovered a novel mechanism that RBM38 is a positive posttranscriptional regulator of ZO-1 in breast cancer. PMID: 28683467
    7. Overexpression of RNA-binding region-containing protein 1 (RNPC1) increased, whereas knockdown of RNPC1 decreased, the level of progesterone receptor (PR) protein and transcripts. PMID: 27634883
    8. aplan-Meier analysis showed that renal cell carcinoma patients with lower expression of RBM38 had a significantly shorter survival time than those with higher expression of RBM38 ( p = 0.028). All these suggested that RBM38 acts as a tumor suppressor in renal cell carcinoma, which has the potential value for the prediction of renal cell carcinoma prognosis. PMID: 28459215
    9. RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation PMID: 26740055
    10. RNPC1 was found to be expressed in bladder, blood, brain, breast, colorectal, eye, head and neck, lung, ovarian, skin and soft tissue cancer. In 14 of the 94 tests, an association between RNPC1 gene expression and cancer prognosis was observed. PMID: 26046131
    11. our data suggest that RBM38 is a novel translational regulator of HIF1alpha under a hypoxic condition. PMID: 25622105
    12. Suggest that RNPC1 had a potential function to play a tumor-suppressor role which may be a potential marker in the therapeutic and prognostic of breast cancer. PMID: 24884756
    13. Data indicate that long non-coding RNA HOTAIR is functionally related to RNA binding motif protein 38 (RBM38). PMID: 24663081
    14. RBM38 as novel transcriptional target of E2F1 restricts E2F1-induced proliferation. Furthermore, this negative feedback loop seems to restrict tumor aggressiveness, thereby promoting survival of patients with cancer. PMID: 22798430
    15. A role for RBM38 in regulating alternative splicing during erythroid differentiation. PMID: 24250749
    16. Data suggest that RNPC1 is a critical regulator of Mdm2. PMID: 23912475
    17. GSK3 promotes p53 mRNA translation through phosphorylation of RNPC1 PMID: 24142875
    18. knockdown of MIC-1 can decrease RNPC1-induced cell growth suppression. PMID: 23836903
    19. Novel regulation of MDM2 gene expression by the RNA binding protein RNPC1 via mRNA stability. PMID: 22710720
    20. knockdown of p73 or p21, another target of RNPC1, attenuates the inhibitory effect of RNPC1 on cell proliferation and premature senescence, whereas combined knockdown of p73 and p21 completely abolishes it PMID: 22508983
    21. a novel mechanism by which HuR is regulated by RNPC1 via mRNA stability and HuR is a mediator of RNPC1-induced growth suppression. PMID: 22371495
    22. RNPC1 contributes to tumor resistance to radiotherapy, which likely occurs through a p21-mediated G/G accumulation mechanism PMID: 22214381
    23. identify RBM38 in a genetic screen for RBPs whose expression controls miRNA access to target mRNAs PMID: 22027593
    24. identified RNPC1, a p53 target and a RNA-binding protein, as a critical regulator of p53 translation PMID: 21764855
    25. found that RNPC1, a RNA-binding protein and a target of the p53 family, regulates p63 mRNA stability and consequently p63 activity. PMID: 20457941
    26. it was found that this protein Rbm38 regulates myogenic differentiation via the p21 signal pathway. PMID: 19817877
    27. RNPC1a is required to maintain the stability of p21 transcript induced by p53. PMID: 17050675

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  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    RBM38 family
  • 数据库链接：

    HGNC: 15818

    OMIM: 612428

    KEGG: hsa:55544

    STRING: 9606.ENSP00000348538

    UniGene: Hs.236361