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  4. Recombinant Human Rab-like protein 1 (PARF)

Recombinant Human Rab-like protein 1 (PARF)

  • 货号：
    CSB-YP663728HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP663728HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP663728HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP663728HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP663728HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RABL6
  • Uniprot No.：
  • 别名：
    bA216L13.9; Chromosome 9 open reading frame 86; FLJ10101; FLJ13045; GTP-binding protein Parf; Hypothetical protein LOC55684; KIAA1984; OTTHUMP00000022608; OTTHUMP00000022610; OTTHUMP00000022612; OTTHUMP00000022613; OTTHUMP00000022614; OTTHUMP00000022615; PARF; Partner of ARF; pp8875; Putative GTP binding protein Parf; Rab like GTP binding protein 1; Rab like GTP binding protein 1C; Rab like protein 1; Rab-like protein 1; RABL6; RBEL1; RBEL1_HUMAN; RP11-216L13.9
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-729
  • 氨基酸序列
    MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM GEHRVILPDD VRDFIDNLDR PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL RQLETNQLDM DATLEELSVQ QETEDQNYGI FLEMMEARSR GHASPLAANG QSPSPGSQSP VVPAGAVSTG SSSPGTPQPA PQLPLNAAPP SSVPPVPPSE ALPPPACPSA PAPRRSIISR LFGTSPATEA APPPPEPVPA AEGPATVQSV EDFVPDDRLD RSFLEDTTPA RDEKKVGAKA AQQDSDSDGE ALGGNPMVAG FQDDVDLEDQ PRGSPPLPAG PVPSQDITLS SEEEAEVAAP TKGPAPAPQQ CSEPETKWSS IPASKPRRGT APTRTAAPPW PGGVSVRTGP EKRSSTRPPA EMEPGKGEQA SSSESDPEGP IAAQMLSFVM DDPDFESEGS DTQRRADDFP VRDDPSDVTD EDEGPAEPPP PPKLPLPAFR LKNDSDLFGL GLEEAGPKES SEEGKEGKTP SKEKKKKKKK GKEEEEKAAK KKSKHKKSKD KEEGKEERRR RQQRPPRSRE RTAADELEAF LGGGAPGGRH PGGGDYEEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.
  • 基因功能参考文献：
    1. Rb knockdown reversed RBEL1 depletion-induced tumor suppressive effects. In conclusion, the present results suggest that RBEL1 modulates cell proliferation and G1S transition by inhibiting Rb in osteosarcoma PMID: 26676380
    2. work identifies RABL6A as a novel negative regulator of Rb1 PMID: 25273089
    3. Breast cancer patients with high levels of C9orf86 expression showed a significant trend towards worse survival compared to patients with low C9orf86 expression. PMID: 23977139
    4. RBEL1A appears to function as a novel p53 negative regulator that facilitates MDM2-dependent p53 ubiquitylation and degradation. PMID: 23572512
    5. RBEL1A and RBEL1B are novel Rab-like proteins that localize in the nucleus and cytosol and may play an important role in breast tumorigenesis PMID: 17962191
    6. characterization of all four RBEL1 splice variants in terms of their GTPase activities, subcellular localizations, regulations & potential functions; results indicate RBEL1 proteins are linked to cell growth & survival & possess unique characteristics PMID: 19433581

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Note=Predominantly cytoplasmic (PubMed:17962191).; [Isoform 3]: Nucleus. Note=Predominantly nuclear (PubMed:17962191).
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 数据库链接：

    HGNC: 24703

    OMIM: 610615

    KEGG: hsa:55684

    STRING: 9606.ENSP00000360727

    UniGene: Hs.370555