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  4. Recombinant Human Ragulator complex protein LAMTOR2 (LAMTOR2)

Recombinant Human Ragulator complex protein LAMTOR2 (LAMTOR2)

  • 中文名称：
    人LAMTOR2重组蛋白
  • 货号：
    CSB-YP897094HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LAMTOR2重组蛋白
  • 货号：
    CSB-EP897094HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LAMTOR2重组蛋白
  • 货号：
    CSB-EP897094HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LAMTOR2重组蛋白
  • 货号：
    CSB-BP897094HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LAMTOR2重组蛋白
  • 货号：
    CSB-MP897094HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    ENDAP ; Endosomal adaptor protein p14; HSPC003 ; LAMTOR2; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; Late endosomal/lysosomal Mp1 interacting protein; Late endosomal/lysosomal Mp1-interacting protein; LTOR2_HUMAN; MAPBPIP ; MAPKSP1 adaptor protein ; MAPKSP1AP ; Mitogen activated protein binding protein interacting protein ; Mitogen-activated protein-binding protein-interacting protein; p14; Ragulator complex protein LAMTOR2; Ragulator2; Roadblock domain containing 3; Roadblock domain containing protein 3 ; Roadblock domain-containing protein 3; ROBLD 3; robld3; RP11 336K24.9
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-125
  • 氨基酸序列
    MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS NIWAAYDRNG NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG FGMLKAKAQA LVQYLEEPLT QVAAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
  • 基因功能参考文献：
    1. In the two wild type (WT) cases, two novel alterations were detected: a complex deletion of APC and a pathogenic mutation of LAMTOR2. Focusing on WT DT subtype, deep sequencing of CTNNB1, APC and LAMTOR2 was conducted on a retrospective series of 11 WT DT using a targeted approach PMID: 29901254
    2. identified polymorphisms in LAMTOR2 and LAMTOR3 do not seem to play a relevant role in breast cancer PMID: 23341997
    3. The ROBLD3 C-A, thorn23 mutation creates a 50SS capable of recruiting an inhibitory U1 snRNP complex leading to a failure of proper 30 end formation and rapid degradation of p14 mRNA. PMID: 22968171
    4. simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1 PMID: 21829671
    5. A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation PMID: 20381137

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  • 相关疾病：
    Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP)
  • 亚细胞定位：
    Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    GAMAD family
  • 数据库链接：

    HGNC: 29796

    OMIM: 610389

    KEGG: hsa:28956

    STRING: 9606.ENSP00000357288

    UniGene: Hs.632483