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  4. Recombinant Human Ras-related C3 botulinum toxin substrate 2 (RAC2)

Recombinant Human Ras-related C3 botulinum toxin substrate 2 (RAC2)

  • 中文名称：
    人RAC2重组蛋白
  • 货号：
    CSB-YP019248HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RAC2重组蛋白
  • 货号：
    CSB-EP019248HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RAC2重组蛋白
  • 货号：
    CSB-EP019248HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RAC2重组蛋白
  • 货号：
    CSB-BP019248HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RAC2重组蛋白
  • 货号：
    CSB-MP019248HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    EN 7; EN-7; EN7; GX; HSPC 022; HSPC022; p21 Rac 2; p21 Rac2; p21-Rac2; p21Rac2; RAC 2; Rac2; RAC2_HUMAN; Ras related C3 botulinum toxin substrate 2 (rho family; small GTP binding protein Rac2; Ras related C3 botulinum toxin substrate 2; Ras related C3 botulinum toxin substrate 3 (rho family; small GTP binding protein Rac2); Ras related C3 botulinum toxin substrate 3; Ras-related C3 botulinum toxin substrate 2; Rho family small GTP binding protein Rac 2; Rho family small GTP binding protein Rac2; Small G protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-189
  • 氨基酸序列
    MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRAC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
  • 基因功能参考文献：
    1. We found both the rs229527 allele within C1QTNF6 (odds ratio [OR] = 1.23, confidence interval [95% CI]: 1.12-1.33, pAllelic = 4.60 . 10-6) and the rs2284038 allele within RAC2 (OR = 1.10, 95% CI: 1.01-0.19, pAllelic = 3.00 . 10-2) showed significant associations with Graves' Disease susceptibility. PMID: 28665696
    2. P38 MAPK, phosphorylated P38 MAPK, and RAC2 regulated in mutual feedback and negative feedback regulatory pathways, resulting in the radioresistance of G0 cells. PMID: 27936335
    3. Rac2 to modulates the level of Rac1-dependent macrophage IL-1beta expression, which consequently determines extent of atherosclerotic calcification. PMID: 27834690
    4. R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR and converging on PLCgamma2 through Rac in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients. PMID: 27542411
    5. Study showed that RhoA/Rac2 participate in hepatocellular tumorigenesis through their upregulation by AFAP1-AS1. PMID: 26892468
    6. RAC2 specifically interacted with a set of mitochondrial proteins. PMID: 26016997
    7. our present analysis reinforces the involvement in ACT of the regulatory NADPH oxidase subunit RAC2 gene variant rs13058338 and, to a lesser extent of the CYBA gene variant rs4673. PMID: 25823784
    8. homozygous loss-of-function RAC2 mutation in 2 patients with early-onset and progressive hypogammaglobulinemia(novel homozygous nonsense mutation in codon 56 (W56X)of RAC2 gene) PMID: 25512081
    9. p47(phox) and Rac2 accumulate only transiently at the phagosome at the onset of NADPH activity and detach from the phagosome before the end of reactive oxygen species production. PMID: 23870057
    10. These studies imply functional importance of iNOS and its interaction with Rac2 in pathogen killing by the neutrophils. PMID: 23875749
    11. Mutations in hematopoiesis-specific Rho GTPases Rac2 and RhoH lead to a wide range of human blood disorders. (Review) PMID: 23850828
    12. This variant reduced binding of the NCF2 gene product p67(phox) to RAC2. This study found a novel genetic association of RAC2 with Crohn's disease (CD) and replicated the previously reported association of NCF4 with ileal CD. PMID: 21900546
    13. Rac2 GTPase alters mitochondrial membrane potential and electron flow through the mitochondrial respiratory chain complex III, generating high levels of reactive oxygen species in chronic-phase CML stem cells and primitive leukemia progenitor cells. PMID: 22411871
    14. data reinforce recent evidences that susceptibility alleles/haplotypes are shared among multiple autoimmune disorders and support a causal role for RAC2 variants in the pathogenesis of autoimmune diseases. PMID: 21680873
    15. CNF1 modified Rac2, which then interacted with the innate immune adaptors IMD and Rip1-Rip2 in flies and mammalian cells, respectively, to drive an immune response PMID: 22018470
    16. activated cells PLD2 affects Rac2 in an initial positive feedback, but as Rac2-GTP accumulates in the cell, this constitutes a "termination signal" leading to PLD2 inactivation. PMID: 21378159
    17. Mutations in RAC2 GTPase have been found to cause a human disease, a severe phagocytic immunodeficiency characterized by lifethreatening infections in infancy. Review. PMID: 21178276
    18. Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 and from each other. PMID: 20007712
    19. Rac2 is activated via a T cell receptor/DOCK2 signal transduction pathway that activates IL-2 transcription in Jurkat cells PMID: 12176041
    20. dissociations of Rac1 and Rac2 from LyGDI enable the PI 3-kinase-dependent translocations of Rac GTPases to the plasma membrane PMID: 12676940
    21. Rac2 does not have the same role as Rac1 in the human NADPH oxidase complex PMID: 12912997
    22. in neutrophils, Rac2 and Cdc42 are involved in FcR- and CR3-induced activation and for properly functioning signal transduction involved in the generation of oxygen radicals. PMID: 12960248
    23. Our results showed a low frequency of mutation and no hot spots of mutation in Rac2 gene in brain tumors, suggesting a decreased possibility of Rac2 in the brain tumorigenesis. PMID: 15812594
    24. diminished rho family, small GTP-binding protein Rac2(Rac2) expression in cord blood neutrophils may contribute to the defects observed in cord blood neutrophil function PMID: 16582540
    25. Endogenous P-Rex1 translocates to areas of Rac2 and cytoskeletal activation at the leading edge in response to chemoattractant stimuli in human neutrophils and that this translocation can be negatively modulated by activation of PKA and by cell adhesion. PMID: 17227822
    26. RACK1 amd Rac2 are components of complexes involved in NK cell homotypic adhesion. PMID: 17269730
    27. These results provide evidence that the activation of Rac2 by angiotensin II is exerted through multiple signalling pathways, involving Ca(2)(+)/calcineurin and protein kinases. PMID: 17975262
    28. DOCK2 and DOCK9 specifically recognize Rac2 and Cdc42 through their switch 1 as well as beta2-beta3 regions and the mode of recognition via switch 1 appears to be conserved among diverse Rac-specific DHR-2 GEFs PMID: 18056264
    29. RAC2 is rarely mutated in gliomas PMID: 18217210
    30. PI3K and Src-ELMO-Dock2 pathways work in parallel to activate Rac2 and modulate chemotaxis in response to a CXCL8 gradient in neutrophils. PMID: 18662984
    31. important in T cell immunological synapse assembly PMID: 18723130
    32. Primary granule exocytosis in human neutrophils is regulated by Rac2-dependent actin remodeling. PMID: 18799653
    33. OAG-induced NOX2 activation was mediated by PKC and PI3K through the regulation of Rac2 activity PMID: 19118104
    34. Human neutrophils kill invading microbes while limiting oxidative damage to the adjacent surrounding healthy tissue through differential activation of Rac1 and Rac2 in response to different concentrations of chemoattractant. PMID: 19625648

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  • 相关疾病：
    Neutrophil immunodeficiency syndrome (NEUID)
  • 亚细胞定位：
    Cytoplasm. Note=Membrane-associated when activated.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 组织特异性：
    Hematopoietic specific.
  • 数据库链接：

    HGNC: 9802

    OMIM: 602049

    KEGG: hsa:5880

    STRING: 9606.ENSP00000249071

    UniGene: Hs.517601