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  4. Recombinant Human Ras-related protein R-Ras2 (RRAS2)

Recombinant Human Ras-related protein R-Ras2 (RRAS2)

  • 中文名称：
    人RRAS2重组蛋白
  • 货号：
    CSB-YP020514HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RRAS2重组蛋白
  • 货号：
    CSB-EP020514HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RRAS2重组蛋白
  • 货号：
    CSB-BP020514HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RRAS2重组蛋白
  • 货号：
    CSB-MP020514HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    C86394; Oncogene RRAS2; Oncogene TC21; Ras like protein TC21; Ras related protein R Ras2; Ras-like protein TC21; Ras-related protein R-Ras2; Related RAS viral (r ras) oncogene homolog 2; Related RAS viral oncogene homolog 2; RRAS 2; RRAS2; RRAS2_HUMAN; TC 21; TC21; Teratocarcinoma oncogene; Teratocarcinoma oncogene TC21
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-201
  • 氨基酸序列
    AAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes. Involved in the regulation of MAPK signaling pathway. Regulation of craniofacial development.
  • 基因功能参考文献：
    1. Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins. PMID: 27936046
    2. R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma. PMID: 24826867
    3. R-RAS2 is overexpressed in the early stages of malignancy in tumors of the human central nervous system. PMID: 24148564
    4. This article is the first study demonstrating expression of TC21 in human skin malignant tumors and suggests that TC21 is more expressed in highly aggressive skin tumors. PMID: 21781067
    5. Suggest that TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma and is associated with tumor progression and poor prognosis in HCC. PMID: 20811707
    6. RasGRF GEFs can activate TC21 in all sublocalizations except the Golgi complex. Farnesylated TC21 can be activated by RasGRF1 & RasGRF2, but geranylgeranylated TC21 is unresponsive to RasGRF2. PMID: 19692568
    7. TGF-beta and TC21 have roles in tumorigenesis PMID: 17656362
    8. TC21 directly links antigen receptors to PI(3)K-mediated survival pathways. PMID: 19561613

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  • 相关疾病：
    Ovarian cancer (OC)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
  • 数据库链接：

    HGNC: 17271

    OMIM: 167000

    KEGG: hsa:22800

    STRING: 9606.ENSP00000256196

    UniGene: Hs.502004