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  4. Recombinant Human Receptor-type tyrosine-protein phosphatase mu (PTPRM), partial

Recombinant Human Receptor-type tyrosine-protein phosphatase mu (PTPRM), partial

  • 货号：
    CSB-YP019058HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019058HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019058HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019058HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019058HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    TPRL 1; hR PTPu; Protein tyrosine phosphatase mu; Protein tyrosine phosphatase mu precursor; Protein tyrosine phosphatase receptor type M; Protein tyrosine phosphatase receptor type mu polypeptide; Protein-tyrosine phosphatase mu; PTPRL1; Ptprm; PTPRM protein; PTPRM_HUMAN; R PTP mu; R-PTP-mu; Receptor type tyrosine protein phosphatase mu ; Receptor-type tyrosine-protein phosphatase mu; RPTP mu; RPTPM; RPTPU
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
  • 基因功能参考文献：
    1. Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment. PMID: 24771611
    2. Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival. PMID: 23185569
    3. Loss of PTPmu by proteolysis causes glioblastoma. PMID: 22505657
    4. Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression. PMID: 21743492
    5. In A549 cells, diverse injurious stimuli dramatically reduced PTPmu protein expression. PMID: 21649524
    6. Loss of protein tyrosine phosphatase receptor type mu is associated with glioma cell migration and progression. PMID: 19304959
    7. RPTPmu may play a role in the regulation of cardiovascular functions PMID: 12895029
    8. PTPmu may regulate Rho-GTPase-dependent functions of IQGAP1 PMID: 16380380
    9. a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions is described PMID: 17761881
    10. BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway. PMID: 18773424
    11. loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells PMID: 19690139

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2B subfamily
  • 数据库链接：

    HGNC: 9675

    OMIM: 176888

    KEGG: hsa:5797

    STRING: 9606.ENSP00000331418

    UniGene: Hs.49774