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  4. Recombinant Human Regulator of G-protein signaling 2 (RGS2)

Recombinant Human Regulator of G-protein signaling 2 (RGS2)

  • 中文名称：
    人RGS2重组蛋白
  • 货号：
    CSB-YP019651HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RGS2重组蛋白
  • 货号：
    CSB-EP019651HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RGS2重组蛋白
  • 货号：
    CSB-BP019651HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RGS2重组蛋白
  • 货号：
    CSB-MP019651HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; G0S8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulator of G-protein signaling 2; Regulators of G protein signaling XRGSVI; RGS 2; RGS2; RGS2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-211
  • 氨基酸序列
    MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
  • 基因功能参考文献：
    1. Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2 in women with preeclampsia PMID: 29593124
    2. RGS2 is suggested as a novel AD biomarker (alongside other genes) toward early AD detection and future disease modifying therapeutics. PMID: 27701409
    3. Upregulated RGS2 contributes significantly to the anti-fibrotic effects of pirfenidone in idiopathic pulmonary fibrosis. PMID: 27549302
    4. study provides functional data for 16 human RGS2 missense variants on their effects on AT1R-mediated calcium mobilization and provides molecular understanding of those variants with functional loss in vitro. PMID: 28784619
    5. Our results suggest that RGS2 might be involved in the pathogenesis of preeclampsia particularly in overweight women and contribute to their increased risk for hypertension and other types of cardiovascular disease later in life. PMID: 27558088
    6. Data suggest that epigenetic changes in histone acetylation and DNA methylation may contribute to the repression of RGS2 (regulator of G-protein signaling 2) expression in chemo-resistant ovarian cancer cells; regulation of HDAC1 (histone deacetylase 1) and DNMT1 (DNA methyltransferase 1) contribute to the suppression of RGS2. PMID: 28102109
    7. The RGS2 (-391, C>G) genetic polymorphism may serve as a biomarker to predict a patient's response to antihypertensive drug therapy PMID: 25849301
    8. MIR4717 regulates human RGS2 and contributes to the genetic risk towards anxiety-related traits. PMID: 25847876
    9. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex. PMID: 25970626
    10. RGS2 polymorphisms were found to be associated with anxiety disorders and dimensional as well as intermediate phenotypes of anxiety. PMID: 25740197
    11. RGS2 localizes to the mitotic spindle in a Nek7-dependent manner, and along with Nek7 contributes to spindle morphology and mitotic spindle pole integrity. PMID: 25664600
    12. genetic variations and increased inflammatory cytokines can lead to RGS2 repression, which exacerbates AHR and airway remodeling in asthma. PMID: 25368964
    13. Data show that regulator of G protein signaling 2 (RGS2) was stabilized by deubiquitinase monocyte chemotactic protein-induced protein 1 (MCPIP1). PMID: 25187114
    14. Epigenetic repression of RGS2 by UHRF1 contributes to bladder cancer progression. UHRF1 inhibits RGS2 expression by increasing the methylation of CpG nucleotides of the RGS2 promoter. PMID: 25323766
    15. ACE and RGS2 genotypes are not associated with the development of hypertension in patients with type 1 diabetes mellitus. PMID: 24562335
    16. This work highlights the role of RGS2 as a key regulator of LRRK2 activity, function and neuronal toxicity. PMID: 24794857
    17. study found that wild-type Met-Gln-Rgs2 and its mutant, Met-Arg-Rgs2, were destroyed by the Ac/N-end rule pathway, which recognizes N(alpha)-terminally acetylated (Nt-acetylated) proteins PMID: 25766235
    18. The results of this study are consistent previous results and support the hypothesis that polymorphic loci RGS2 gene associated with risk of extrapyramidal symptoms induced by typicalneuroleptics-haloperidol, and are involved in schizophrenia pathway. PMID: 25509855
    19. Women carrying the rs4606 CG or GG genotype are at elevated risk for developing hypertension after delivery following a preeclamptic pregnancy. PMID: 24593135
    20. This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. PMID: 23859711
    21. observations support the concept of a functional activation-dependent p63RhoGEF-Galphaq-RGS2 complex PMID: 24299002
    22. ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected. PMID: 24297163
    23. RGS2 promoter of hypertensive patients abolished HSF1-regulated expression of RGS2, suggesting that activated HSF1 is involved in blood pressure regulation via modulation of RGS2 expression PMID: 23587726
    24. The study was unable to replicate or extend prior association findings between RGS2 variants and various anxiety-related phenotypes using a large, independent sample. PMID: 23277133
    25. Data show that miR-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 and HDAC4 mRNAs. PMID: 23349832
    26. It was shown that the RGS2 rs4606 single nucleotide polymorphism may affect the risk and progression of preeclampsia. PMID: 23339167
    27. The variants and their frequencies in RGS2 gene in Kazakh hypertensives may have ethnic differences when compared with other populations. PMID: 21529451
    28. In vivo treatment with digoxin led to increased RGS2 protein levels in heart and kidney. PMID: 22695717
    29. Loss of RGS2 also increased ASM mass and stimulated airway smooth muscle cell growth via extracellular signal-regulated kinase and phosphatidylinositol 3-kinase pathways PMID: 22704538
    30. Reduced RGS2 protein expression in human prostate cancer specimens. PMID: 21500190
    31. Data identify RGS2 gene expression as a genomic mechanism of bronchoprotection that is induced by glucocorticoids plus beta(2)-adrenoceptor agonist (LABA) in airway smooth muscle. PMID: 22080612
    32. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 PMID: 22057271
    33. Findings both identify RGS2 downregulation as a novel compensatory response in HD neurons and suggest that RGS2 inhibition might be considered as an innovative target for neuroprotective drug development. PMID: 21779398
    34. genetic polymorphisms in RGS2 are associated with intima-media thickening of carotid artery in humans. PMID: 21451528
    35. The haplotypes T-G-C and T-C-T showed significant association and protective effect on Panic disorder; results provide support for an association of RGS2 with panic disorder in a Japanese population PMID: 21438143
    36. The essential roles of both N-terminal subdomains for the potent inhibitory activity of RGS2 on AT1 receptor signaling. PMID: 21291998
    37. down-regulation of RGS2 might play an important role in colorectal cancer (CRC) metastasis and predict poor prognosis in stage II and III CRC patients. PMID: 20001967
    38. These findings suggest that RGS2 may not be genetically involved in the biological susceptibility to panic disorder in Japanese. PMID: 20847599
    39. platelet Gs signaling defect caused by a heterozygous RGS2 variant that results in a unique mutational mechanism, such as the differential use of translation initiation sites resulting in different functional RGS2 isoforms. PMID: 20403096
    40. The D allele of 1891-1892 TC insertion/deletion of RGS2 might be an independent risk factor for hypertension in Xinjiang Kazakhs. PMID: 20662725
    41. data suggest that RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo PMID: 20633139
    42. Reduced RGS2 expression contributes to resistance to antihypertensive agents through poor negative feedback on the effects of aldosterone and of other vasoactive agents. PMID: 20375904
    43. The D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene is an independent risk factor for hypertension in a Chinese population. PMID: 20140863
    44. Ischemic stress increases RGS2 expression and that this condition contributes to enhanced apoptosis in C6 cells and primary astrocytes. PMID: 20032508
    45. Phosphoglycerate kinase 2 (PGK2) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure. PMID: 19778949
    46. rs4606 does not affect AIEPSs in Japanese subjects. PMID: 19931593
    47. RGS2 plays a role in regulating purinergic signaling in human broncheotracheal cells PMID: 12356577
    48. Identification of RGS2 and type V adenylyl cyclase interaction sites. PMID: 12604604
    49. RGS-2 level in human clinical condition characterized by altered vascular tone. Importance of RGS-2 as key regulator element for Ang II signaling. Links between Bartter's/Gitelman's syndrome genetic abnormalities and abnormal vascular tone regulation. PMID: 15292363
    50. TSH-dependent RGS 2 mRNA expression and the suppression of TSH-G(q)alpha signaling by the overexpression of RGS 2 imply that RGS 2 is involved in TSHR-induced G(q) signal transduction. PMID: 15362969

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 2]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 3]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 4]: Cell membrane. Mitochondrion.
  • 组织特异性：
    Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
  • 数据库链接：

    HGNC: 9998

    OMIM: 600861

    KEGG: hsa:5997

    STRING: 9606.ENSP00000235382

    UniGene: Hs.78944