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  4. Recombinant Human Relaxin-3 (RLN3)

Recombinant Human Relaxin-3 (RLN3)

  • 货号：
    CSB-YP823903HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP823903HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP823903HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP823903HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP823903HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RLN3
  • Uniprot No.：
  • 别名：
    RLN3; INSL7; RXN3; ZINS4; UNQ6188/PRO20213; Relaxin-3; Insulin-like peptide INSL7; Insulin-like peptide 7; Prorelaxin H3) [Cleaved into: Relaxin-3 B chain; Relaxin-3 A chain]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    26-52
  • 氨基酸序列
    RAAPY GVRLCGREFI RAVIFTCGGS RW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    May play a role in neuropeptide signaling processes. Ligand for LGR7, RXFP3 and RXFP4.
  • 基因功能参考文献：
    1. Serum level of relaxin-3 hormone is an important mediator in the pathophysiological process of normal puberty being significantly decreased in males with delayed puberty. PMID: 28786126
    2. Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research. PMID: 27498038
    3. the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3, to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3, respectively. PMID: 27193232
    4. In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting. PMID: 27488261
    5. the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 PMID: 27353281
    6. Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5. PMID: 27888281
    7. Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour. PMID: 26272327
    8. Review of research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion. PMID: 24988606
    9. we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor PMID: 24641548
    10. Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3. PMID: 24615237
    11. Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4. PMID: 24802387
    12. Relaxin-2 or relaxin-3 levels are not related to component traits in patients with diabetes. PMID: 23994775
    13. metabolic syndrome is associated with increased serum relaxin-3 levels in women PMID: 23018057
    14. [review] Relaxin-3 (RXF3P) is expressed within GABA neurons of the brainstem including an area known as the nucleus incertus; ascending relaxin-3 projections innervate a broad range of RXFP3-rich forebrain areas. PMID: 21693186
    15. H3 relaxin exerts antifibrotic actions via RXFP1 receptor PMID: 21229994
    16. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. PMID: 19778557
    17. relaxin-3/INSL7 is a ligand for GPCR142 PMID: 14522967
    18. GPCR135 is the receptor for relaxin-3 PMID: 14522968
    19. RLN3 chimeric peptide is a potential tool to study in vivo function of GPCR135. PMID: 15465925
    20. Intracerebroventricular injections of human relaxin-3 (H3) to satiated rats significantly increased food intake. PMID: 15845619
    21. NMR spectroscopy and simulated annealing calculations were used to determine the three-dimensional structure of relaxin-3 and to identify key structural differences between the human relaxins. PMID: 15956686
    22. functional response to H3 relaxin and other relaxin/insulin peptides of GPCR135 expressed in CHO-K1 cells was measured in the cytosensor microphysiometer and analyzed using inhibitors of signal transduction proteins PMID: 15956730
    23. Results describe the solution structure of human relaxin-3. PMID: 16365033
    24. Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3. PMID: 19152634

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 数据库链接：

    HGNC: 17135

    OMIM: 606855

    KEGG: hsa:117579

    STRING: 9606.ENSP00000397415

    UniGene: Hs.352155