Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Reticulocalbin-3 (RCN3)

Recombinant Human Reticulocalbin-3 (RCN3)

  • 中文名称：
    人RCN3重组蛋白
  • 货号：
    CSB-YP856914HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RCN3重组蛋白
  • 货号：
    CSB-EP856914HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RCN3重组蛋白
  • 货号：
    CSB-EP856914HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RCN3重组蛋白
  • 货号：
    CSB-BP856914HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RCN3重组蛋白
  • 货号：
    CSB-MP856914HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RCN3
  • Uniprot No.：
  • 别名：
    EF-hand calcium-binding protein RLP49; RCN3; RCN3_HUMAN; reticulocalbin 3, EF-hand calcium binding domain; Reticulocalbin-3; RLP49; UNQ239/PRO272
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-328
  • 氨基酸序列
    KPSPDAGPHG QGRVHQAAPL SDAPHDDAHG NFQYDHEAFL GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA ELRAWIAHTQ QRHIRDSVSA AWDTYDTDRD GRVGWEELRN ATYGHYAPGE EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM RDIVIAETLE DLDRNKDGYV QVEEYIADLY SAEPGEEEPA WVQTERQQFR DFRDLNKDGH LDGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA EILGNWNMFV GSQATNYGED LTRHHDEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
  • 基因功能参考文献：
    1. genome-wide association study in US: Data suggest, among white subjects, an SNP in RCN3 (rs34459162) and a missense mutation in GCKR (rs1260236) are associated with serum levels of glycated albumin; among black subjects, an intergenic SNP in PRKCA (rs2438321) is associated with fructosamine levels and intronic variant in PRKCA (rs59443763) is associated with glycated albumin levels. (GCKR = glucokinase regulatory protein) PMID: 29844224
    2. RCN3 expression in systemic sclerosis was not statistically significantly different to healthy controls. PMID: 27468573
    3. Autoactivation & secretion of rat PACE4 was increased upon co-expression with recombinant human RCN-3. Selective and transient association of RCN-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4. PMID: 16433634
  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    CREC family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 21145

    KEGG: hsa:57333

    UniGene: Hs.567550