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  4. Recombinant Human Retinoic acid receptor gamma (RARG)

Recombinant Human Retinoic acid receptor gamma (RARG)

  • 货号：
    CSB-YP019340HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019340HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019340HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019340HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019340HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RARG
  • Uniprot No.：
  • 别名：
    NR1B3; Nuclear receptor subfamily 1 group B member 3; RAR gamma; RAR gamma isoform 2; RAR gamma2; RAR-gamma; RARC; Rarg; RARG_HUMAN; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor gamma
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-454
  • 氨基酸序列
    MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY ELSPQLEELI TKVSKAHQET FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL KMEIPGPMPP LIREMLENPE MFEDDSSQPG PHPNASSEDE VPGGQGKGGL KSPA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
  • 基因功能参考文献：
    1. Study reports that retinoic acid receptor-gamma (RARgamma) is a negative regulator of p53 signaling and thus extend the oncogenic potential of RARgamma to a new role in controlling the balance between AKT and p53. PMID: 28336971
    2. the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein kinase 1 (RIP1)-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked. PMID: 28871172
    3. Results show that RARgamma expression is significantly upregulated in human hepatocellular carcinoma (HCC) tissues and demonstrate that RARgamma could promote HCC invasion and metastasis by regulating E-cadherin reduction. PMID: 27756432
    4. Our study is the first to report that treatment with a RARgamma specific agonist augments cellular adhesion to alpha5beta1 integrin substrates, increases cell surface levels of the beta1 integrin subunit, and dampens cellular proliferation in a time and concentration dependent manner in a human erythroleukemia cell line PMID: 28552962
    5. Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis. PMID: 27325643
    6. RARgamma might serve as a potential therapeutic target for chemoresistant colorectal cancer patients. PMID: 28272990
    7. A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers. PMID: 26237429
    8. deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98-RARG-mediated transformation PMID: 25510432
    9. RARgamma in concert with ATRA regulates protein levels of CDK1 and its subcellular localization. PMID: 23518499
    10. RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt/NF-kappaB and Wnt/beta-catenin pathways. PMID: 23798555
    11. Low RARgamma expression is associated with advanced gastric cancer. PMID: 22901127
    12. Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene. PMID: 22362749
    13. findings demonstrate that signaling through RARs has critical roles in molecular reprogramming and that the synergistic interaction between Rarg and Lrh1 directs reprogramming toward ground-state pluripotency PMID: 21990348
    14. results suggest that a RARgamma-dependent functional crosstalk is present between the retinoic acid and BMP2 signaling to induce osteogenic transdifferentiation in myoblastic C2C12 cells PMID: 21401418
    15. Microbiota are required for the generation of both IL-17-positive and Foxp3-positive, retinoic acid-related orphan receptor gamma-positive transgenic T cell subsets in the intestinal lamina propria. PMID: 21178008
    16. PARgamma expressions are decreased in PBMC and SWAT of obese subjects in weight gain. PMID: 20387030
    17. Retinoic acid receptor gamma 2 could specifically interact with vitamin D response elements, either in the presence or absence of the vitamin D receptor. PMID: 20420906
    18. Retinoid signaling is attenuated by retinoic acid-induced proteasome-mediated degradation of RARG in human keratocytes. PMID: 11855864
    19. Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. PMID: 12189556
    20. The 1.4 A resolution crystal structure of the ligand binding domain of the retinoic acid receptor RARgamma complexed with the retinoid SR11254 reveals several types of C-H...O hydrogen bonds PMID: 12220491
    21. Present throughout the epithelium with minimal nuclear accumulation. Increased in basal and luminal epithelial nuclei in glands with benign prostatic hyperplasia. PMID: 12399530
    22. RARgamma interact only weakly with SMRT. PMID: 12554770
    23. In a 9-cis retinoic acid-dependent fashion in cells in vitro, retinoic acid receptor isoform gamma stimulates the expression of reporter constructs containing the site that binds aldehyde dehydrogenase-2. PMID: 14691372
    24. Tazarotene is a prodrug selective for RARbeta/gamma, thereby motivating interest in determining whether tazarotene might activate putative tumor suppressor activity. PMID: 15383624
    25. phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta PMID: 15734736
    26. study elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction that is negatively regulated by CSK and is required for RA-induced neuronal differentiation PMID: 17325034
    27. analysis to determine directly whether PML-RAR, like PML-RAR, is able to induce APL PMID: 18685608
    28. The first 2250 bp of the HAS2 promoter contain three response elements (REs) for the transcription factor CREB1 as well as two REs for the nuclear receptor RAR PMID: 19416972
    29. the subcellular localization of RARgamma is regulated by complex interactions among ligand binding, receptor phosphorylation, and receptor dimerizations PMID: 19416983

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 组织特异性：
    Expressed in aortic endothelial cells (at protein level).
  • 数据库链接：

    HGNC: 9866

    OMIM: 180190

    KEGG: hsa:5916

    STRING: 9606.ENSP00000377947

    UniGene: Hs.1497