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  4. Recombinant Human Rho-related GTP-binding protein RhoV (RHOV)

Recombinant Human Rho-related GTP-binding protein RhoV (RHOV)

  • 中文名称：
    人RHOV重组蛋白
  • 货号：
    CSB-YP842703HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RHOV重组蛋白
  • 货号：
    CSB-EP842703HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RHOV重组蛋白
  • 货号：
    CSB-EP842703HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RHOV重组蛋白
  • 货号：
    CSB-BP842703HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RHOV重组蛋白
  • 货号：
    CSB-MP842703HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RHOV
  • Uniprot No.：
  • 别名：
    ARHV; CDC42-like GTPase 2; Chp; GTP binding protein like 2; GTP-binding protein-like 2; Rho GTPase-like protein ARHV; Rho V; Rho-related GTP-binding protein RhoV; RHO5; Rhov; RHOV_HUMAN; Wnt-1 responsive Cdc42 homolog 2; WRCH-2; WRCH2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-236
  • 氨基酸序列
    MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.
  • 基因功能参考文献：
    1. s propose that the RHOV gene could be validated as a diagnostic or prognostic marker for NSCLC, and that observed overexpression of RHOV might contribute to tumorigenesis. PMID: 24388711
    2. CDC42 homologous protein does not enhance the level of Ser60 phosphorylation in Pak6. (RHO V protein) PMID: 22339630
    3. cloning and characterization of WRCH2 on human chromosome 15q15 PMID: 11956592
    4. Data suggest that Chp is implicated in cell transformation, and the unique amino and carboxyl termini of Chp represent atypical mechanisms of regulation of Rho GTPase function. PMID: 15664990
    5. Results demonstrate a novel mechanism of signal termination mediated by the Rho-family GTPases Chp and Cdc42, which results in ubiquitin-mediated degradation of one of their direct effectors, Pak1. PMID: 17355222

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 组织特异性：
    Highly expressed in pancreas, placenta, and fetal brain.
  • 数据库链接：

    HGNC: 18313

    KEGG: hsa:171177

    STRING: 9606.ENSP00000220507

    UniGene: Hs.447901