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  4. Recombinant Human Rhomboid-related protein 2 (RHBDL2), partial

Recombinant Human Rhomboid-related protein 2 (RHBDL2), partial

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  • 中文名称：
    人RHBDL2重组蛋白
  • 货号：
    CSB-EP019672HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019672HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RHBDL2.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019672HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RHBDL2.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    RHBDL2
  • Uniprot No.：
  • 别名：
    RHBDL2; Rhomboid-related protein 2; RRP2; EC 3.4.21.105; Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2; N-terminal fragment; NTF); Rhomboid-related protein 2; C-terminal fragment; CTF)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    18.2kDa
  • 表达区域：
    12-132aa
  • 氨基酸序列
    MNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEAWRFISYMLVHAG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.
  • 基因功能参考文献：
    1. Thrombomodulin and RHBDL2 are upregulated in human HaCaT cells stimulated by scratch wounds; furthermore, increased solulbe thrombomodulin was found in culture medium. PMID: 21833011
    2. RHBDL2 cleaves epidermal growth factor just outside its transmembrane domain, thereby facilitating its secretion and triggering activation of the epidermal growth factor receptor. PMID: 21494248
    3. Substrate specificity of RHBDL2 intramembrane protease is governed by helix-breaking residues in the transmembrane domain. PMID: 12820957
    4. Here, the s show that RHBDL2 is produced as a proenzyme and that the processing of RHBDL2 is required for its cellular protease activity. PMID: 19850051
    5. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. PMID: 15047175

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  • 亚细胞定位：
    [Rhomboid-related protein 2, C-terminal fragment]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peptidase S54 family
  • 数据库链接：

    HGNC: 16083

    OMIM: 608962

    KEGG: hsa:54933

    STRING: 9606.ENSP00000289248

    UniGene: Hs.524626