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  4. Recombinant Human S-adenosylmethionine decarboxylase proenzyme (AMD1)

Recombinant Human S-adenosylmethionine decarboxylase proenzyme (AMD1)

  • 货号：
    CSB-YP001658HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001658HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001658HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001658HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001658HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    AMD1
  • Uniprot No.：
  • 别名：
    Adenosylmethionine decarboxylase 1; AdoMetDC; AMD1; DCAM_HUMAN; EC 4.1.1.50; FLJ26964; S adenosylmethionine decarboxylase 1; S adenosylmethionine decarboxylase proenzyme; S-adenosylmethionine decarboxylase beta chain; SAMDC
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-67
  • 氨基酸序列
    MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPRSEW DILLKDVQCS IISVTKTDKQ EAYVLSE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
  • 基因功能参考文献：
    1. AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation PMID: 29310120
    2. AMD1 is upregulated in human prostate cancer with activated mTORC1 PMID: 28658205
    3. AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark. PMID: 26558825
    4. Gene expression studies have identified altered expression of AMD1 in suicide completers with a history of mood disorders. PMID: 23260169
    5. This study demomistrated that H3K4me3 modification plays an important role in up regulation of AMD1 in prefrontal cortex. PMID: 22008221
    6. Genetic variant of AMD1 is associated with obesity. PMID: 22496743
    7. Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants. PMID: 21134486
    8. Decreased AMD1 is associated with prostate cancer. PMID: 20215859
    9. AdoMetDC is ubiquitinated and degraded by the 26 S proteasome PMID: 14718534
    10. The adhesion-dependent expression of SAM-DC and ODC contributes to extracellular matrix-dependent salivary gland cell differentiation. PMID: 15521072
    11. For such cells, gamma-radiation and cisplatin, which are direct DNA-damaging agents, were very effective for promoting cell death. PMID: 17069747
    12. schizophrenia and bipolar disorder patients, the increase of S-adenosyl methionine is associated with an overexpression of DNA methyltransferase-1 mRNA in Brodmann's area 9 GABAergic neurons. PMID: 17259861
    13. Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells PMID: 18548481
    14. Binding of putrescine to wild type dimeric ADOMETDC protein is cooperative; putrescine activates the enzyme through electrostatic effects and acts as a switch to correctly orient key catalytic residues. PMID: 19053272
    15. determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223 PMID: 19527050

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  • 蛋白家族：
    Eukaryotic AdoMetDC family
  • 数据库链接：

    HGNC: 457

    OMIM: 180980

    KEGG: hsa:262

    STRING: 9606.ENSP00000357880

    UniGene: Hs.159118