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  4. Recombinant Human SOSS complex subunit B1 (OBFC2B)

Recombinant Human SOSS complex subunit B1 (OBFC2B)

  • 中文名称：
    人NABP2重组蛋白
  • 货号：
    CSB-YP858412HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NABP2重组蛋白
  • 货号：
    CSB-EP858412HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NABP2重组蛋白
  • 货号：
    CSB-EP858412HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NABP2重组蛋白
  • 货号：
    CSB-BP858412HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NABP2重组蛋白
  • 货号：
    CSB-MP858412HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NABP2
  • Uniprot No.：
  • 别名：
    NABP2; OBFC2B; SSB1; LP3587; SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-211
  • 氨基酸序列
    MTTETFVKDI KPGLKNLNLI FIVLETGRVT KTKDGHEVRT CKVADKTGSI NISVWDDVGN LIQPGDIIRL TKGYASVFKG CLTLYTGRGG DLQKIGEFCM VYSEVPNFSE PNPEYSTQQA PNKAVQNDSN PSASQPTTGP SAASPASENQ NGNGLSAPPG PGGGPHPPHT PSHPPSTRIT RSQPNHTPAG PPGPSSNPVS NGKETRRSSK R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
  • 基因功能参考文献：
    1. findings demonstrate a novel hSSB1 regulatory mechanism for the repair of damaged DNA PMID: 27273218
    2. Our data highlights that BLM helicase and hSSB1 function in a dynamic complex in cells and that this complex is likely required for BLM protein stability and function. PMID: 28506294
    3. the detailed molecular mechanism in solution of ssDNA binding by hSSB1, a major player in the maintenance of genomic stability, is reported. PMID: 27387285
    4. In the absence of hSSB1, human 8-oxoguanine glycosylase 1 does not localize to chromatin, resulting in the accumulation of 8-oxoguanine in the genome. PMID: 26261212
    5. The findings demonstrate the importance of hSSB1 in maintaining and repairing DNA replication forks and for overall genomic stability. PMID: 24753408
    6. Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway. PMID: 24104880
    7. SOSS complexes, containing SSB1, do not localize with Replication Protein A (RPA) to replication sites in human cells, yet have a strong effect on double-strand break resection and homologous recombination. PMID: 23178594
    8. Cells deficient in hSSB1 exhibit increased radiosensitivity, defective checkpoint activation and enhanced genomic instability coupled with a diminished capacity for DNA repair. PMID: 18449195
    9. INTS3 controls the SSB1-mediated DNA damage response. PMID: 19786574

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  • 亚细胞定位：
    Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
  • 蛋白家族：
    SOSS-B family, SOSS-B1 subfamily
  • 数据库链接：

    HGNC: 28412

    OMIM: 612104

    KEGG: hsa:79035

    STRING: 9606.ENSP00000267023

    UniGene: Hs.240170