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  4. Recombinant Human Sal-like protein 4 (SALL4), partial

Recombinant Human Sal-like protein 4 (SALL4), partial

In Stock
  • 货号：
    CSB-BP892126HU(M)
  • 规格：
    ￥3168
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    SALL4
  • Uniprot No.：
  • 别名：
    AA407717; AL022809; AW536104; C330011P20Rik; C78083; C78563; dJ1112F19.1; DRRS; HSAL4; Sal like 4 (Drosophila); Sal like 4; Sal like Protein 4; Sal-like protein 4; Sall4; SALL4_HUMAN; Spalt like transcription factor 4; Tex20; Zinc finger protein 797; Zinc finger protein SALL4; ZNF797
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    Baculovirus
  • 分子量：
    16
  • 表达区域：
    954-1053aa+11R
  • 氨基酸序列
    PKEILAPSVNVDPVVWNQYTSMLNGGLAVKTNEISVIQSGGVPTLPVSLGATSVVNNATVSKMDGSQSGISADVEKPSATDGVPKHQFPHFLEENKIAVS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
  • 基因功能参考文献：
    1. an HBV-pSTAT3-SALL4-miR-200c axis regulates PD-L1 causing T cell exhaustion PMID: 29593314
    2. the TRIM21 knockdown increases SALL1 levels, indicating that TRIM21 degrades both SALL1 and SALL4. PMID: 29511085
    3. These data indicate that aberrantly expressed SALL4 in human choriocarcinoma cells may promote cell proliferation via beta-catenin/c-Myc pathway PMID: 28639477
    4. SALL4 was significantly upregulated in glioma tissues and cell lines, and an inverse correlation between miR-98 and SALL4 expression in glioma tissues was identified. PMID: 29436585
    5. TNFSF13, SPATC1L, SLC22A25 and SALL4 may thus be novel susceptibility loci for atrial fibrillation in the Japanese population PMID: 28849223
    6. Study showed significantly high expression of SALL4 mRNA in glioma specimens as compared to non-tumor samples using RT-PCR. Blocking SALL4 using SALL4-siRNA decreased proliferation of U87 and U251 cells, which was reversed by the addition of PTEN inhibitor phen (bpv). Furthermore, marked increase in PTEN mRNA and protein levels was seen in cells treated with siRNA-SALL4. PMID: 28887597
    7. SALL4 is a promising prognostic biomarker for cancer, and is appropriate for the assessment of cancer prognosis in the Chinese people. PMID: 28582841
    8. Our experimental data indicated that over expression of SALL4 was found in CRC and low expression of SALL4 was connected with high survival rate after surgery. Thus our study suggested that SALL4 could serve as a potential diagnostic and prognostic marker of CRC. PMID: 28869451
    9. SALL4 is a target gene of miR-181b in glioma.SALL4 is upregulated in glioma. PMID: 27938503
    10. SALL4 is a target gene of mir-98 in non-small cell lung cancer cells. PMID: 27938506
    11. miR-98 plays a suppressive role in the proliferation, migration, invasion and EMT of HCC cells, partly at least, via directly inhibition of SALL4. PMID: 27677076
    12. SALL4 immunopositivity is not a prognostic factor in Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) (cHCC-CC); however, it is associated with alpha-fetoprotein, glypican 3 and EpCAM immunopositivity, indicating the mechanism of carcinogenesis. PMID: 26267070
    13. these data suggest that Bmi-1 could serve as a novel prognostic biomarker in pediatric primary acute lymphoblastic leukemia (ALL)and may be partially regulated by Sall4a. Our study also showed that Bmi-1 could serve as a new therapeutic target for the treatment of pediatric ALL. PMID: 28122538
    14. SALL4 overexpression is associated with neoplasms. PMID: 27007163
    15. Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1/2)/YAP signaling, and that inhibition of miR-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 and SALL4. PMID: 28103766
    16. Study showed that SALL4 was overexpressed in a majority of human esophageal squamous cell carcinoma (ESCC) tissues and that aberrantly activated SALL4 may contribute to esophageal tumorigenesis by promoting malignant proliferation and inhibiting cell apoptosis, regulating esophageal squamous cell migration, invasion and cell cycle. PMID: 27329034
    17. Data show that SALL4 promotes the expression of Glut1 and open chromatin through a HP1alpha-dependent mechanism. PMID: 28759035
    18. Our report is the first description of structural eye defects associated with two missense variants in SALL4 inherited in trans; the absence of reported findings in both parents suggests that both sequence variants are hypomorphic mutations and that both are needed for the ocular phenotype. PMID: 27661448
    19. our study showed that SALL4 plays an important role in regulating the proliferation, migration, and invasion of osteosarcoma cells. PMID: 27983924
    20. The SALL4 - integrin alpha6 - integrin beta1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells. PMID: 27773610
    21. Coexpression of SALL4 with HDAC1 and/or HDAC2 was associated with PTEN underexpression and a poor prognosis in hepatocellular carcinoma. PMID: 28411180
    22. SALL4 has a negative impact in DNA damage repair, and support the model of dual functional properties of SALL4 in leukemogenesis through inhibiting DNA damage repair and promoting cell survival. PMID: 27132514
    23. demethylation of CpGs located within OCT4 and STAT3 cis-acting elements, downstream of SALL4 TSS, enables OCT4 and STAT3 binding, recruitment of BRG1, and enhanced RNA polymerase II elongation and SALL4 transcription PMID: 27797380
    24. SALL4 was expressed in 100% of choriocarcinomas and it was not detected in any placental site trophoblastic tumor and epithelioid trophoblastic tumor. PMID: 27068524
    25. SALL4 is useful for subtyping hepatoblastoma, and high SALL4 expression is associated with decreased survival in hepatoblastoma. PMID: 27252091
    26. expression detected in 36% of undifferentiated/dedifferentiated endometrial carcinomas, not other in high-grade endometrial carcinomas PMID: 28272224
    27. miR33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of SALL4 expression. PMID: 28026002
    28. this study demonstrates that miR-16 plays a suppressive role in regulating cell proliferation, migration and invasion, and EMT in glioma, at least in part by directly targeting SALL4. PMID: 27748823
    29. We evaluate the effects of siRNA-inhibited expression of the SALL4 gene on the proliferation, colony formation, and apoptosis of prostate cancer C4-2 cells. Silencing SALL4 expression by using siRNA technology inhibited the proliferation and colony formation of C4-2 cells, and promoted apoptosis likely mediated by Bcl-2 and Bax expression. PMID: 27323021
    30. the under-expression of SOX1 was associated significantly with SALL4 overexpression. This study was the first to evaluate SOX1 underexpression and its association with poor prognosis in esophageal squamous cell carcinoma. PMID: 27576349
    31. Hepatocellular carcinoma patients with higher expression levels of SALL4 and AFP have worse prognosis. PMID: 26973422
    32. Persistent expression of SALL4 in metastatic MGCTs resistant to chemoradiation also raises the possibility for targeted systemic therapy as the anti-SALL4 peptide continues to be developed PMID: 25906119
    33. SALL4 and beta-catenin were positively correlated in colorectal cancer. PMID: 26779651
    34. SALL4 was highly expressed and correlated with poor prognosis in SOC patients, promoting invasion and metastasis of OC cells. PMID: 26750614
    35. Study reports a novel heterozygous frameshift insertion in SALL4, c.410dupG (p.Gly138Argfs*43) segregating with Okihiro syndrome in a Brazilian pedigree with five affected individuals; the c.410dupG variant in SALL4 gene reported here is the cause of Okihiro syndrome without Duane anomaly, but with foot defect in one affected individual. PMID: 26791099
    36. By inhibition of SALL4 expression, the proliferation, invasiveness and drug resistance were dramatically reduced while apoptosis rate was up-regulated. PMID: 26617716
    37. SALL4 expression in squamous cell carcinoma of the esophagus may constitute a sign of dedifferentiation leading to poor patient prognosis PMID: 26818834
    38. SALL4 has an oncogenic role in intrahepatic cholangiocarcinoma PMID: 26317546
    39. review aims to summarize our current knowledge of SALL4, including a SALL4-based approach to classify and target cancers PMID: 26892498
    40. SALL4 could induce Epithelial-mesenchymal transition and resistance to antineoplastic drugs through the regulation of c-Myc. SALL4 and c-Myc may be novel therapeutic targets for endometrial cancer. PMID: 26407074
    41. The results show that miR-219-5p inhibited carcinogenesis of colon cancer by targeting oncogene Sall4 PMID: 26238082
    42. identifies the KRLR sequence as a bona fide nuclear localization signal for SALL4B. PMID: 24626181
    43. An atypical 0.73 MB microduplication of 22q11.21 and a novel SALL4 missense mutation associated with thumb agenesis and radioulnar synostosis. PMID: 25823593
    44. The mechanism through which miR-33b inhibits the stemness, migration and invasion of breast cancer cells is by targeting HMGA2, SALL4 and Twist1. PMID: 25919570
    45. Results indicate that SALL4 overexpression acts as a natural resistance factor and may be involved in the recurrence of lung cancer after adjuvant chemotherapy. PMID: 25646965
    46. Results indicated that the SALL4 may play an important role in progression, development and maintenance of glioma PMID: 25359397
    47. Despite moderate sensitivity, SALL4 expression may aid in distinguishing Malignant rhabdoid tumours from epithelioid sarcomas PMID: 24827994
    48. Aberrant SALL4 expression has been found in nearly all AML cases, whereas, in normal bone marrow and peripheral blood cells, its expression is only restricted to hematopoietic stem/progenitor cells. PMID: 25737450
    49. the evaluation of ERG and SALL4 immunoexpressions may be a useful diagnostic tool to distinguish epithelioid sarcoma, especially proximal type, from malignant rhabdoid tumor PMID: 25479928
    50. SALL4 has functional roles in metastasis and drug resistance in aggressive endometrial cancer PMID: 24336327

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  • 相关疾病：
    Duane-radial ray syndrome (DRRS); Oculootoradial syndrome (OORS)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Sal C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML).
  • 数据库链接：

    HGNC: 15924

    OMIM: 147750

    KEGG: hsa:57167

    STRING: 9606.ENSP00000217086

    UniGene: Hs.517113