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  4. Recombinant Human Sclerostin domain-containing protein 1 (SOSTDC1)

Recombinant Human Sclerostin domain-containing protein 1 (SOSTDC1)

  • 货号：
    CSB-EP022416HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    SOSTDC1
  • Uniprot No.：
  • 别名：
    CDA019; DKFZp564D206; Ectodermal BMP inhibitor; Ectodin; sclerostin domain containing 1; Sclerostin domain containing protein 1; Sclerostin domain-containing protein 1; SOSD1_HUMAN; Sostdc1; USAG-1; USAG1; Uterine sensitization associated gene 1 protein; Uterine sensitization-associated gene 1 protein; Wise
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    47.8kDa
  • 表达区域：
    24-206aa
  • 氨基酸序列
    FKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
  • 基因功能参考文献：
    1. findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways. PMID: 28551845
    2. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2. PMID: 26378658
    3. Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. PMID: 25338303
    4. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer PMID: 25858146
    5. Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1. PMID: 24190897
    6. DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer. PMID: 23830730
    7. SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer. PMID: 21113658
    8. Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women. PMID: 21221677
    9. genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors. PMID: 21080955
    10. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
    11. USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist. PMID: 15020244
    12. This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1 (sclerostin domain-containing-1) as down-regulated in kidney tumors. PMID: 18032587
    13. Loss of SOSTDC1 gene is associated with Wilms tumor. PMID: 19760604

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Sclerostin family
  • 组织特异性：
    Highly expressed in kidney and weakly in lung.
  • 数据库链接：

    HGNC: 21748

    OMIM: 609675

    KEGG: hsa:25928

    STRING: 9606.ENSP00000304930

    UniGene: Hs.648106