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  4. Recombinant Human Secreted frizzled-related protein 3 (FRZB)

Recombinant Human Secreted frizzled-related protein 3 (FRZB)

  • 货号：
    CSB-YP835696HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP835696HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP835696HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP835696HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP835696HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FRZB
  • Uniprot No.：
  • 别名：
    FRZB; FIZ; FRE; FRP; FRZB1; SFRP3; Secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    33-325
  • 氨基酸序列
    AACEPVRI PLCKSLPWNM TKMPNHLHHS TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF QHEPIKPCKS VCERARQGCE PILIKYRHSW PENLACEELP VYDRGVCISP EAIVTADGAD FPMDSSNGNC RGASSERCKC KPIRATQKTY FRNNYNYVIR AKVKEIKTKC HDVTAVVEVK EILKSSLVNI PRDTVNLYTS SGCLCPPLNV NEEYIIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLSK SDSSNSDSTQ SQKSGRNSNP RQARN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
  • 基因功能参考文献：
    1. active involvement in placental development and important role in pathology of pregnancy PMID: 28738713
    2. Systemic and local levels of sFRP3 protein are downregulated in osteosarcoma. PMID: 29933019
    3. we observed that FRZB regulates integrin beta1D expression, its silencing increasing integrin beta1D expression to levels similar to those in controls. PMID: 28300015
    4. endogenous expression of the WNT antagonists DKK1 and FRZB is necessary for multiple steps during chondrogenesis PMID: 27733096
    5. this study shows that sFRP3 regulates fibroblast-like synociocyte transformation PMID: 28151034
    6. This may suggest that SFRP3 acts as an agonist of Wnt signaling and promotes invasive behavior. PMID: 27035837
    7. The secreted frizzled-related protein and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors. PMID: 27599467
    8. FRZB expression was up-regulated in hepatocellular carcinoma bone metastasis tissue, which suggested that FRZB might play a key role in the HCC bone metastasis. PMID: 26722540
    9. Positive expression of FRZB was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis. PMID: 26097596
    10. Intermediate SFRP3 levels are associated with better survival and fewer cardiovascular events than low or high SFRP3 levels, independently of conventional risk factors, in older patients with chronic systolic Heart Failure of ischemic origin. PMID: 26288364
    11. Intermediate levels of sFRP3 were a predictor of all-cause mortality and re-hospitalization in acute coronary syndromes. PMID: 25920031
    12. Data suggest secreted FRP3 (frizzled related protein-3) interacts with ADAM17 (A disintegrin/metalloprotease 17) substrate IL6R (interleukin-6 receptor) release; this interaction is down-regulated in osteoarthritis due to rare double variant in FRP3. PMID: 25846075
    13. study indicates that increased expression of both SFRP1 and SFRP3 may contribute to the pathogenesis of IUGR placental dysfunction, whereas the loss of these proteins may be involved in the development of human trophoblastic tumors. PMID: 25046226
    14. These data indicate an important role of methylation-induced gene silencing of the sFRP gene family in human GBM. PMID: 24948145
    15. Our results suggest that the sFRP3 c.970C>G and sFRP4 c.958C>A polymorphisms may be genetic factors associated with the prevalence of osteoporosis at the femoral neck in postmenopausal Korean women. PMID: 24662300
    16. Promoter hypermethylation of SFRP3 is a common event hepatocellular carcinoma. PMID: 24591760
    17. FRZB knockdown may upregulate the Wnt/betacatenin pathway and promote aggressiveness in gastric cancer. PMID: 24676361
    18. The compound heterozygosity for mutations in the MFRP gene described in the present study should severely affect the function of MFRP by completely removing the cubilin, LDL-A and frizzled-related CRD domains. PMID: 23742260
    19. Data indicate an inverse correlation between osteoarthritis and GREM1, FRZB and DKK1 gene expression. PMID: 24286177
    20. There is an association between increased sFRP3 expression and adverse outcome in heart failure. PMID: 24330105
    21. Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in human. PMID: 23207650
    22. Studied the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC). PMID: 23572277
    23. The rs7775 SNP in exon 6 of SFRP3 gene that codes for either arginine or glycine exhibited very strong association with breast cancer, even after Bonferroni's correction. PMID: 23516639
    24. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. PMID: 22544526
    25. SFRP3 functions as a melanoma migration and invasion suppressor by interfering with Wnt5a signaling. PMID: 21494614
    26. Loss of WNT pathway inhibition due to SFRP3 gene silencing is associated with medulloblastoma. PMID: 20208569
    27. sFRP3 expression promotes cell growth, invasion, and inhibition of apoptosis in renal cancer cells. PMID: 20160027
    28. The expression of FRZB in gastric cancer is correlated with tumor cell differentiation and tumor Lauren classification. PMID: 18344084
    29. Our results suggest that natural variation in FRZB is not a major contributor to the observed variability in peak bone mineral density in either Chinese females or males PMID: 20043861
    30. functional polymorphisms within FRZB confer susceptibility for hip osteoarthritis in females and implicate the wnt signaling pathway in the pathogenesis of this disease PMID: 15210948
    31. methylation silencing of SFRPs may be one of the important mechanisms of aberrant Wnt signaling activation in MM PMID: 15221014
    32. The R324G variant of the FRZB gene is involved in osteoarthritis and has a role in several generalized osteoarthritis phenotypes. PMID: 15818669
    33. presence of a small degree of differential allelic expression in a low proportion of individuals studied suggests that polymorphism in FRZB cis-acting regulatory elements can be discounted as a major factor influencing development of osteoarthritis PMID: 16889986
    34. The FRZB 200Trp allele may be a marker for ''positive'' bone phenotype after total hip arthroplasty that is characterized by a positive association with the development of heterotopic ossification and a negative association with osteolysis. PMID: 17600823
    35. FRZB suppressed gastric cancer cell proliferation and modulated the balance between proliferation and differentiation in gastric cancer. PMID: 17680269
    36. In 60 multiple myeloma patients checked, it was found that among the Wnt inhibitors, Dickkopf-1 and secreted frizzled-related protein-3 were produced by multiple myeloma cells. PMID: 17702698
    37. No association was seen between FRZB, LRP5 and LRP6 variants with radiographic osteoarthritic outcomes in two population-based cohorts PMID: 18406176
    38. Usefulness of Frzb in modulating Met signaling as a new treatment strategy for soft tissue sarcomas. PMID: 18451162
    39. Study showed no association between the FRZB polymorphisms or haplotypes and the risk of colorectal cancer or adenoma overall. PMID: 19067193
    40. Findings do not support the notion that FRZB rs7775 or rs288326 have any sizable genetic effect on osteoarthritis phenotypes. PMID: 19479880

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  • 相关疾病：
    Osteoarthritis 1 (OS1)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Secreted frizzled-related protein (sFRP) family
  • 组织特异性：
    Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot
  • 数据库链接：

    HGNC: 3959

    OMIM: 165720

    KEGG: hsa:2487

    STRING: 9606.ENSP00000295113

    UniGene: Hs.128453