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  4. Recombinant Human Secreted frizzled-related protein 5 (SFRP5)

Recombinant Human Secreted frizzled-related protein 5 (SFRP5)

  • 货号：
    CSB-YP021141HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021141HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021141HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021141HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021141HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    SFRP5; FRP1B; SARP3; Secreted frizzled-related protein 5; sFRP-5; Frizzled-related protein 1b; FRP-1b; Secreted apoptosis-related protein 3; SARP-3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-317
  • 氨基酸序列
    E EYDYYGWQAE PLHGRSYSKP PQCLDIPADL PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC HSDTQVFLCS LFAPVCLDRP IYPCRSLCEA VRAGCAPLME AYGFPWPEML HCHKFPLDND LCIAVQFGHL PATAPPVTKI CAQCEMEHSA DGLMEQMCSS DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT KRLVLHMKNG AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS YPCSLYYPFF YGAAEPH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
  • 基因功能参考文献：
    1. results revealed the epigenetic silencing of SFRP5 by promoter methylation plays pivotal roles in chondrosarcoma development and metastasis through SFRP5/Wnt/beta-catenin signaling axis; modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of chondrosarcoma PMID: 30125549
    2. Sfrp5 may be an adipokine that is associated with the pathogenesis of Metabolic Syndrome in humans. PMID: 28303637
    3. Higher serum SFRP5 was inversely associated with multiple risk factors for type 2 diabetes and cardiovascular disease. PMID: 28851362
    4. This review article focuses on the effects of SFRP5 on the major systems of the body and on its association with the Wnt signaling pathways--{review} PMID: 25003224
    5. SFRP5 confers protection against oxidative stress-induced apoptosis through inhibition of beta-catenin activation and downregulation of Bax. PMID: 28834606
    6. serum concentration correlated with blood pressure in obese children and increased in response to lifestyle intervention PMID: 27882931
    7. The inverse association of serum Sfrp5 with beta-cell function suggests a detrimental role of Sfrp5 for insulin secretion also in humans. The severity of NAFLD does not appear to affect this relationship. The weak association between serum Sfrp5 and insulin sensitivity was partially explained by body mass. PMID: 27019073
    8. Results identify several coding and non-coding variants in the sFRP5 gene region, the majority of which resulted in a non-synonymous amino acid change in the protein. One of the variants (c.-3G[A) shows a trend towards association between the variant frequency and the obese phenotype. PMID: 27497818
    9. Results indicate that miR-125b can regulate SFRP5 expression and thus influence the growth and activation of cardiac fibroblasts. PMID: 27592695
    10. Decreased first trimester serum Sfrp-5 levels are significantly associated with the increased risk of gestational diabetes mellitus. PMID: 26100762
    11. Report reduced hepatic SFRP5 expression in morbidly women with NAFLD. PMID: 26256895
    12. Data suggest that serum SFRP5 levels are up-regulated in subjects with newly diagnosed type 2 diabetes as compared to prediabetic or control subjects; subjects were matched for obesity/overweight/body mass index. PMID: 25139699
    13. Sfrp5 represents a candidate for a mature adipocyte marker gene. PMID: 25324487
    14. The wnt5a/sFRP5 system is altered in human sepsis and might therefore be of interest for future studies on molecular pathophysiology of this common human disease. PMID: 25382802
    15. Serum SFRP5 is regulated by weight status and seems to be correlated with metabolic disorders in children. PMID: 24330025
    16. We were able to show a significant association of sFRP5 with both total abdominal and subcutaneous fat. The association signal was only seen in obese males in which the minor allele of rs7072751 explains 1.8 % of variance in total abdominal fat. PMID: 24287795
    17. SFRP5 and WNT5A comprise a balanced duo that may regulate metabolic homeostasis in prepubertal children. PMID: 24603290
    18. Secreted frizzled-related protein 5 suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through down-regulation of c-Jun N-terminal kinase. PMID: 24764263
    19. Serum SFRP5 levels significantly correlated with body mass index, the homeostasis model of assessment of insulin resistance, adiponectin levels, and CAD severity. Low SFRP5 levels may contribute to CAD. PMID: 24530778
    20. Therefore, cytokine release and insulin signaling were analyzed to investigate the impact of Sfrp5 on inflammation and insulin signaling in primary human adipocytes and skeletal muscle cells (hSkMC). PMID: 24465779
    21. SFRP5 gene methylation in leukemia cells activates Wnt/ss-catenin signaling to upregulate mdr1/P-gp expression and cause multidrug resistance. PMID: 24434572
    22. Wnt5a overproduction and SFRP5 deficiency in gastric mucosa may together play an important role in gastric inflammation and carcinogenesis. PMID: 24416340
    23. Epigenetic silencing of SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway PMID: 24374650
    24. Sfrp5 may play a role in the pathogenesis of T2 Diabetes mellitus. PMID: 23653377
    25. Plasma levels of SFRP5 were decreased in Chinese obese and T2DM subjects. SFRP5 was an independent factor affecting glucolipid metabolism, inflammation and insulin resistance. PMID: 23290274
    26. Patients with unmethylated SFRP5 are more likely to benefit from EGFR-TKI therapy. PMID: 23009178
    27. Circulating Sfrp5 is likely to play a major role in insulin resistance in humans. PMID: 23185036
    28. findings suggest that epithelium-derived SFRP5 may play a probable defensive role in impeding gastric cancer progression, characteristically by inhibiting GEC migration induced by macrophage-derived Wnt5a via JNK signaling activation PMID: 23054609
    29. Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects PMID: 22384249
    30. Promoter hypermethylation of SFRP5 is associated with Acute myeloid leukemia. PMID: 20795789
    31. data suggested that epigenetic silencing of SFRP5 leads to oncogenic activation of the Wnt pathway and contributes to ovarian cancer progression and chemoresistance through the TWIST-mediated EMT and AKT2 signaling PMID: 19957335
    32. The SFRP5 protein gene plays an important role in the pathogenesis of bladder tumor and can be detected using cellular DNA extracted from urine samples. PMID: 16609023
    33. In its role as tumor suppressor gene. SFRP5 methylation may be a novel DNA-based biomarker potentially useful in clinical breast cancer management. PMID: 18356147
    34. Loss of SFRP5 is associated with oral squamous cell carcinoma PMID: 18497987
    35. SFRP5 promoter hypermethylation was significantly more frequent in microsatellite unstable colorectal neoplasms. PMID: 18795670
    36. In multiple myeloma cell lines, hypermethylation of SFRP5 was associated with transcriptional silencing. SFRP5 methylation was restricted to advanced MM stages & plasma-cell leukemia and may play a role in disease progression. PMID: 19299079
    37. SFRP5 is downregulated and inversely correlated with MMP-7 and MT1-MMP in gastric cancer PMID: 19586554

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Secreted frizzled-related protein (sFRP) family
  • 组织特异性：
    Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.
  • 数据库链接：

    HGNC: 10779

    OMIM: 604158

    KEGG: hsa:6425

    STRING: 9606.ENSP00000266066

    UniGene: Hs.279565