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  4. Recombinant Human Semaphorin-3E (SEMA3E)

Recombinant Human Semaphorin-3E (SEMA3E)

  • 中文名称：
    人SEMA3E重组蛋白
  • 货号：
    CSB-YP020984HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SEMA3E重组蛋白
  • 货号：
    CSB-EP020984HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SEMA3E重组蛋白
  • 货号：
    CSB-EP020984HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SEMA3E重组蛋白
  • 货号：
    CSB-BP020984HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SEMA3E重组蛋白
  • 货号：
    CSB-MP020984HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SEMA3E
  • Uniprot No.：
  • 别名：
    Coll 5; Coll5; KIAA0331; M sema H; M SEMAH; M SemaK; Msema H; MSEMAH; MSemaK; OTTHUMP00000206419; OTTHUMP00000206420; SEM3E_HUMAN; Sema domain immunoglobulin domain (Ig); Sema domain immunoglobulin domain (Ig) short basic domain secreted 3E; Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; SEMA3E; SEMAH; Semaphorin 3E; Semaphorin H, mouse, homolog of; Semaphorin-3E; Semaphorin3E; Short basic domain secreted (semaphorin) 3E
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-775
  • 氨基酸序列
    ADTTH PRLRLSHKEL LNLNRTSIFH SPFGFLDLHT MLLDEYQERL FVGGRDLVYS LSLERISDGY KEIHWPSTAL KMEECIMKGK DAGECANYVR VLHHYNRTHL LTCGTGAFDP VCAFIRVGYH LEDPLFHLES PRSERGRGRC PFDPSSSFIS TLIGSELFAG LYSDYWSRDA AIFRSMGRLA HIRTEHDDER LLKEPKFVGS YMIPDNEDRD DNKVYFFFTE KALEAENNAH AIYTRVGRLC VNDVGGQRIL VNKWSTFLKA RLVCSVPGMN GIDTYFDELE DVFLLPTRDH KNPVIFGLFN TTSNIFRGHA ICVYHMSSIR AAFNGPYAHK EGPEYHWSVY EGKVPYPRPG SCASKVNGGR YGTTKDYPDD AIRFARSHPL MYQAIKPAHK KPILVKTDGK YNLKQIAVDR VEAEDGQYDV LFIGTDNGIV LKVITIYNQE MESMEEVILE ELQIFKDPVP IISMEISSKR QQLYIGSASA VAQVRFHHCD MYGSACADCC LARDPYCAWD GISCSRYYPT GTHAKRRFRR QDVRHGNAAQ QCFGQQFVGD ALDKTEEHLA YGIENNSTLL ECTPRSLQAK VIWFVQKGRE TRKEEVKTDD RVVKMDLGLL FLRLHKSDAG TYFCQTVEHS FVHTVRKITL EVVEEEKVED MFNKDDEEDR HHRMPCPAQS SISQGAKPWY KEFLQLIGYS NFQRVEEYCE KVWCTDRKRK KLKMSPSKWK YANPQEKKLR SKPEHYRLPR HTLDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation.
  • 基因功能参考文献：
    1. Sema3E induced cell proliferation via acting through the MAPK/ERK pathway. PMID: 27911862
    2. Sema3E could be considered an essential regulatory mediator involved in modulation of neutrophil migration throughout the course of neutrophilic inflammation. PMID: 27913633
    3. Results show high expression level of SEMA3E which correlated with lymph node involvement, metastatic progression and a significant association with poor prognosis in gastric cancer patients. Also, in vitro studies reveal that SEMA3E caused cell proliferation and anchorage-independent cell growth in the intestinal type of gastric cancer. PMID: 27572291
    4. suggested that miR-4282 is a tumor suppressor in colorectal carcinoma cells and exerted its inhibitory effect on the tumor cells through targeting Sema3E by inhibiting Sema3E translation or enhancing Sema3E mRNA degradation PMID: 27120047
    5. This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E and what effect semaphorin 3E exerts on carotid atherosclerosis. PMID: 28249916
    6. s suggest that silencing of Sema3E contributes to the pathogenesis of gastric cancer. PMID: 26036259
    7. Findings suggest that Plexin-D1/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc) endothelium. PMID: 26292963
    8. Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F. PMID: 26086095
    9. these results identify SEMA3E as an essential gene for GnRH neuron development, uncover a neurotrophic function for SEMA3E in the developing brain PMID: 25985275
    10. The ANGPTL4 may be a candidate target in DME treatment and a biomarker of ischemic-induced retinopathy, including diabetic retinopathy. PMID: 25687026
    11. Semaphorin 3d requires neuropilin 1 or PI3K/Akt, whereas semaphorin 3e requires plexin D1 in directing endothelial motility. PMID: 24825896
    12. The identification and characterization of SH3BP1 as a novel downstream effector of Sema3E-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior. PMID: 24841563
    13. Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration. PMID: 23932461
    14. A critical role of Sema3E/Plexin D1 interaction in tumor resistance to apoptosis. PMID: 24139859
    15. Loss of Sema3E expression is associated with biochemical recurrence of patients with low- and intermediate-risk prostate cancer. PMID: 23906303
    16. Furin-resistant Sema3E inhibits endothelial cells and hampers tumour angiogenesis and tumour growth. PMID: 22247010
    17. analysis of Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer PMID: 21559368
    18. a novel phospholipid-regulated antiangiogenic signaling pathway whereby Sema3E activates Arf6 through Plexin-D1 and consequently controls integrin-mediated endothelial cell attachment to the extracellular matrix and migration. PMID: 21795701
    19. SEMA3E is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    20. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice PMID: 21505259
    21. Semaphorin 3E is aberrantly expressed in prostate cancer and affects cell adhesion and motility, indicating a role in the Sems3E/PlexinD1 signaling pathway. PMID: 20949546
    22. Sema3E-Plexin D1 signaling in cancer cells is crucially implicated in their metastatic behavior and may therefore be a promising target for strategies aimed at blocking tumor metastasis. PMID: 20664171
    23. The translocation envolving chromosomes 2 and 7 with SEMA3E within 200 kb of the translocation breakpoint on 7q21.11 in a patient with CHARGE syndrome. PMID: 15235037
    24. These results show that PLXND1 expression during tumor development is strongly correlated with both invasive behavior and metastasis, but exclude Sema3E as an activating ligand. PMID: 18974298
    25. Sema3E inhibits tumor progression from MDA-231 but not MDA-435 cells. It inhibits tumors angiogenesis, but less effectively then other tested class-3 semaphorins. Tumor inhibition might be as a result of the expression levels of PlexD1 on the tumor cells. PMID: 18818766

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Semaphorin family
  • 数据库链接：

    HGNC: 10727

    OMIM: 608166

    KEGG: hsa:9723

    STRING: 9606.ENSP00000303212

    UniGene: Hs.528721