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  4. Recombinant Human Serine incorporator 5 (SERINC5), partial

Recombinant Human Serine incorporator 5 (SERINC5), partial

  • 货号：
    CSB-YP021050HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021050HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021050HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021050HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021050HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SERINC5
  • Uniprot No.：
  • 别名：
    C5orf12; SERC5_HUMAN; SERINC5; Serine incorporator 5; TPO1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes.
  • 基因功能参考文献：
    1. Experiments using SERINC5(S5) S5- SERINC2(S5) chimeric proteins revealed two functional domains for restriction: one necessary for S5 incorporation into virions, which does not seem to be necessary for restriction, and a second one necessary to change the HIV-1 envelope conformation, localize to DRMs, and block infection. PMID: 29268082
    2. Data suggest that restriction of HIV-1 particle infectivity by host-cell SERINC5 (which is antagonized by viral Nef) does not depend on alterations in lipid composition and organization of HIV-1 particles and suggest that channeling serine into lipid biosynthesis may not be a cardinal cellular function of SERINC5. (SERINC5 = serine incorporator 5; Nef = nef gene product, HIV1gp9) PMID: 28659343
    3. Ser5-001 isoform transcripts are produced at least 10-fold more than the others; only Ser5-001 produces stable proteins that are targeted to the plasma membrane; only Ser5-001 shows strong anti-HIV-1 activity; the extra transmembrane domain is required for Ser5 stable expression and plasma membrane localization; results suggest plasma membrane localization is required for Ser5 antiviral activity PMID: 28275190
    4. The increased HIV-1 sensitivity to anti-gp41 antibodies and peptides suggests that SER5 also delays refolding of the remaining fusion-competent Env trimers. PMID: 28179429
    5. results suggest that the antagonism of HIV-1 Nef to SERINC5 restriction of virion infectivity is mediated by a dual mechanism that is related to CD4 downregulation PMID: 27681140
    6. SERINC3 and SERINC5 together restricted HIV-1 replication, and this restriction was evaded by Nef PMID: 26416733
    7. identification of the host transmembrane protein SERINC5, and to a lesser extent SERINC3, as a potent inhibitor of HIV-1 particle infectivity that is counteracted by Nef PMID: 26416734
    8. results from a first genome-wide association study of Borderline personality disorder, which shows a promising signal on chromosome 5 corresponding to SERINC5, a protein involved in myelination. PMID: 23979607
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    10. the apparent occurrence of an unusual TG 3' splice site in intron 11 is discussed PMID: 17672918

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.; Cytoplasm, perinuclear region.
  • 蛋白家族：
    TDE1 family
  • 组织特异性：
    Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain.
  • 数据库链接：

    HGNC: 18825

    OMIM: 614551

    KEGG: hsa:256987

    STRING: 9606.ENSP00000420863

    UniGene: Hs.288232