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  4. Recombinant Human Serine protease HTRA4 (HTRA4)

Recombinant Human Serine protease HTRA4 (HTRA4)

  • 中文名称：
    人HTRA4重组蛋白
  • 货号：
    CSB-YP010904HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HTRA4重组蛋白
  • 货号：
    CSB-EP010904HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HTRA4重组蛋白
  • 货号：
    CSB-EP010904HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HTRA4重组蛋白
  • 货号：
    CSB-BP010904HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HTRA4重组蛋白
  • 货号：
    CSB-MP010904HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HTRA4
  • Uniprot No.：
  • 别名：
    FLJ90724; High temperature requirement protean A4; High-temperature requirement factor A4; HTRA 4; HtrA serine peptidase 4; HTRA4; HTRA4_HUMAN; Probable serine protease HTRA4; Serine protease HTRA4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    32-476
  • 氨基酸序列
    EKLHTQPSC PAVCQPTRCP ALPTCALGTT PVFDLCRCCR VCPAAEREVC GGAQGQPCAP GLQCLQPLRP GFPSTCGCPT LGGAVCGSDR RTYPSMCALR AENRAARRLG KVPAVPVQWG NCGDTGTRSA GPLRRNYNFI AAVVEKVAPS VVHVQLWGRL LHGSRLVPVY SGSGFIVSED GLIITNAHVV RNQQWIEVVL QNGARYEAVV KDIDLKLDLA VIKIESNAEL PVLMLGRSSD LRAGEFVVAL GSPFSLQNTA TAGIVSTKQR GGKELGMKDS DMDYVQIDAT INYGNSGGPL VNLDGDVIGV NSLRVTDGIS FAIPSDRVRQ FLAEYHEHQM KGKAFSNKKY LGLQMLSLTV PLSEELKMHY PDFPDVSSGV YVCKVVEGTA AQSSGLRDHD VIVNINGKPI TTTTDVVKAL DSDSLSMAVL RGKDNLLLTV IPETIN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine protease.
  • 基因功能参考文献：
    1. the aberrant expression of HTRA1 or HTRA4 may be involved in the onset of preeclampsia, and increased HTRA1 or HTRA4 expression may affect trophoblast functions. PMID: 30015931
    2. GATA3 knockdown elevated HtrA4 expression in BeWo and JEG-3 trophoblast cell lines and enhanced the invasion activities of both lines. This study uncovered a new GATA3 function in placenta as a negative regulator of GCM1 activity and trophoblastic invasion. PMID: 26899996
    3. HtrA4 represents a novel placenta-specific serine protease that is altered specifically in early-onset preeclampsia with potential causal roles in endothelial dysfunction and disease development. PMID: 25946029
    4. Conditioned media from these two cell lines after decidualization treatment suppress HtrA4-expressing JAR cell invasion in an HtrA1- or HtrA3-dependent manner. PMID: 25002585
    5. Data suggest that increased HtrA4 (and HtrA1) in placenta tissues may be involved in onset of pre-eclampsia; elevated level of HtrA4 (but not HtrA1) in sera has potential as biomarker for pre-eclampsia. PMID: 22964307
    6. study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia PMID: 22778138
    7. FLJ90724 or HTRA4 is a member of the HtrA family of proteases PMID: 12408815

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1C family
  • 数据库链接：

    HGNC: 26909

    OMIM: 610700

    KEGG: hsa:203100

    STRING: 9606.ENSP00000305919

    UniGene: Hs.661014