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  4. Recombinant Human Signal transducer and activator of transcription 4 (STAT4)

Recombinant Human Signal transducer and activator of transcription 4 (STAT4)

  • 货号：
    CSB-YP022813HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022813HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022813HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022813HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022813HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Signal transducer and activator of transcription 4; SLEB11; STAT4; STAT4_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-748
  • 氨基酸序列
    MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIEN QDWEAASNNE TMATILLQNL LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH VAVVISNCLR EERRILAAAN MPVQGPLEKS LQSSSVSERQ RNVEHKVAAI KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT MDQSDKNSAM VNQEVLTLQE MLNSLDFKRK EALSKMTQII HETDLLMNTM LIEELQDWKR RQQIACIGGP LHNGLDQLQN CFTLLAESLF QLRRQLEKLE EQSTKMTYEG DPIPMQRTHM LERVTFLIYN LFKNSFVVER QPCMPTHPQR PLVLKTLIQF TVKLRLLIKL PELNYQVKVK ASIDKNVSTL SNRRFVLCGT NVKAMSIEES SNGSLSVEFR HLQPKEMKSS AGGKGNEGCH MVTEELHSIT FETQICLYGL TIDLETSSLP VVMISNVSQL PNAWASIIWY NVSTNDSQNL VFFNNPPPAT LSQLLEVMSW QFSSYVGRGL NSDQLHMLAE KLTVQSSYSD GHLTWAKFCK EHLPGKSFTF WTWLEAILDL IKKHILPLWI DGYVMGFVSK EKERLLLKDK MPGTFLLRFS ESHLGGITFT WVDHSESGEV RFHSVEPYNK GRLSALPFAD ILRDYKVIMA ENIPENPLKY LYPDIPKDKA FGKHYSSQPC EVSRPTERGD KGYVPSVFIP ISTIRSDSTE PHSPSDLLPM SPSVYAVLRE NLSPTTIETA MKSPYSAE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Carries out a dual signal transduction and activation of transcription. Involved in IL12 signaling.
  • 基因功能参考文献：
    1. the present study postulates that the genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population. PMID: 30044774
    2. Lack of association of rs7574865 and rs7601754 SNPs in STAT4 gene with susceptibility to JSLE in Iranian population, despite their association with the risk of adult SLE in the same population, implicates on difference of genetic background of JSLE and SLE. PMID: 29276866
    3. No significant associations between STAT4 variant and serum neopterin or disease activity parameters were identified. The study confirmed the association of STAT4 rs7574865 polymorphism with rheumatoid arthritis and was the first to indicate an association with rheumatoid factor and anti-cyclic citrullinated peptide antibodies positivity. PMID: 28424905
    4. 5 STAT4 SNPs were tested in 233 patients with established NMOSD and 492 healthy controls. Allelic, additive, dominant, and recessive models identified associations with NMOSD. Minor alleles of 4 STAT4 SNPs exhibited significant association with increased risk of NMOSD: rs7574865 T; rs10181656 G; rs10168266 T; and rs13426947 A in all models. rs7601754 G displayed a protective effect against NMOSD. PMID: 28852993
    5. data demonstrate that STAT4 plays a role in enabling the normal and timely division of cells undergoing mitosis PMID: 28516569
    6. Genome-wide association study identified a locus in STAT4, rs13390936, associated with nontyphoidal Salmonella bacteremia. PMID: 29523850
    7. Neither alleles nor genotypes of rs7601754 SNP of STAT4 gene demonstrated associations with juvenile rheumatoid arthritis (JRA). We recognize that gene variants of STAT4 did not affect JRA susceptibility in an Iranian population. PMID: 28524764
    8. STAT4 is a novel transcriptional regulator of p66Shc in normal and chronic lymphocytic leukemia B cells PMID: 27494881
    9. IL13 AA of rs20541 and STAT4 TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 TT did not respond to high-dose ICSs. PMID: 26765219
    10. STAT4 mRNA expression was significantly correlated with IFNG mRNA expression. PMID: 29187449
    11. findings demonstrate that variants in STAT4 play a critical role in HBV infection and clearance in the Chinese Han population. PMID: 27444301
    12. STAT4 rs7574865G/T polymorphism is associated with rheumatoid arthritis and systemic lupus erythematosus in Mexican women PMID: 27178308
    13. STAT4_rs7574865 TT was associated with the presence of actively inflamed joints and extra-articular damage in patients with Juvenile Idiopathic Arthritis. PMID: 28145159
    14. Results found that activated STAT4 was overexpressed in epithelial cells of ovarian cancer and provide evidence that it promotes ovarian cancer metastasis via tumor-derived Wnt7a-induced activation of cancer-associated fibroblasts. PMID: 28114283
    15. STAT4 rs7574865 gene polymorphism is associated with the susceptibility of primary biliary cirrhosis in the Han population of Jiangsu province. PMID: 28395724
    16. The findings results confirm the important role of STAT4 gene in the predisposition to Systemic sclerosis and its phenotypes, such as the presence of Interstitial Lung disease , cardiac injury , and seropositivity for anti-topoisomerase I antibodies in the Russian population. PMID: 28631694
    17. results show specific and dominant contribution of STAT4 in the hematopoietic compartment to metabolic health and inflammation in diet-induced obesity. PMID: 28400678
    18. reported that SNPs in STAT4, PTPN2, PSORS1C1, and TRAF3IP2 are associated with response to TNF-i treatment in RA patients; however, these findings should be validated in a larger population PMID: 28107378
    19. This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-alpha/beta signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells. PMID: 26990433
    20. A higher risk to develop RA was observed for rs7574865 in the STAT-4 gene, while the rs1800872 in the IL-10 gene showed a protective effect. PMID: 27342690
    21. STAT4 rs7574865 polymorphism has a role in rheumatoid arthritis and disease activity, but not in anti-CCP antibody levels in a Mexican population PMID: 27234231
    22. this study shows that STAT4 single nucleotide polymorphism affects clinical outcomes of pediatric acute leukemia patients after hematopoietic stem cell transplant PMID: 27960128
    23. this study shows that STAT4 gene polymorphisms are associated with ankylosing spondylitis in Southwest China PMID: 27394003
    24. Our results for the first time showed a significant association between STAT4 rs7582694 alleles and genotypes and susceptibility to endometriosis in a population. PMID: 27235632
    25. we can conclude that STAT4-rs7574865 polymorphism is clearly associated with the risk of Rheumatoid Arthritis in the Western Algerian population PMID: 25351936
    26. The results demonstrated that STAT4 rs7574865 and IRF5 rs2004640G/T substitution are associated with a susceptibility to systemic sclerosis. PMID: 26712637
    27. Our findings indicate that although STAT4 and IFIH1 SNPs are not associated with T1D in a Brazilian population, they might play a role in susceptibility to T1D on a larger worldwide scale PMID: 26782418
    28. SNP rs7574865 in STAT4 might contribute to progression to Hepatocellular Carcinoma. PMID: 26745093
    29. Five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC. PMID: 26538132
    30. There is a significant association between STAT4 rs7574865 polymorphism and IBD susceptibility in overall population. PMID: 26066297
    31. STAT4 protein genetic variation is a prognostic factor predicting the treatment with interferon-alpha therapy in chronic hepatitis B. PMID: 26704347
    32. the presence of the rs7574865 T allele enhances STAT4 mRNA transcription and protein expression PMID: 26569609
    33. STAT4 rs7574865 polymorphism may be associated with significantly reduced risk of HBV-induced HCC in Asian PMID: 25178516
    34. gene polymorphisms along with Ptpn22 polymorphism confers susceptibility to rheumatoid arthritis in all major ethnic groups. [meta-analysis] PMID: 25963842
    35. Significant association with alleles of two STAT4 markers and nominal association of Autoimmune Addison's disease with alleles at GATA3, is reported. PMID: 24614117
    36. our replication study showed that the rs7574865 in STAT4 and rs9275319 in HLA-DQ were not associated with CHB-related HCC in a Korean population. PMID: 25913043
    37. CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 are bona fide susceptibility genes for Behcet's disease. PMID: 26097239
    38. STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms as susceptibility factors for JIA PMID: 25781893
    39. STAT4 minor allele may be associated with the spontaneous clearance of HBV, whereas the major allele may be associated with the progress of the HBV-related liver disease. PMID: 25829184
    40. STAT4 may inhibit HCC development by modulating HCC cell proliferation. PMID: 25852285
    41. Review/Meta-analysis: STAT4 rs7574865 polymorphism confers susceptibility to rheumatoid arthritis in major ethnic groups. PMID: 24751105
    42. Evidence of a higher risk to develop pericarditis with STAT4 genotypes, and an association between HCP5 rs3099844 and anti-Ro/SSA antibodies in Italian systemic lupus erythematosus patients. PMID: 25369137
    43. STAT4 rs7574865 seems to be Tibetan specific in hepatitis B virus natural clearance. PMID: 25041342
    44. STAT4 rs7574865 seemed not to correlate with hepatitis B virus infection susceptibility or natural clearance; its role in hepatocellular carcinoma development seemed ambiguous PMID: 25365208
    45. Loss of STAT4 expression and associated switch to Th2 phenotype during Mycosis Fungoides progression may be driven via aberrant histone acetylation and/or upregulation of oncogenic miR-155 microRNA. PMID: 25486484
    46. Increased expression of STAT4 is positively correlated with the depth of invasion in colorectal cancer patients. PMID: 25864744
    47. This work reported the association of 14q32.11 (EFCAB11) with Hepatocellular carcinoma in Chinese Han population and revealed the genetic interaction between STAT4 (2q32.2-q32.3) and EFCAB11 (14q32.11) in Hepatocellular carcinoma. PMID: 25665738
    48. STAT4 rs7574865/rs10181656 polymorphisms increase the risk of autoimmune thyroid diseases in a Chinese population. PMID: 25019342
    49. Rheumatoid arthritis cases showed a significantly higher frequency of the STAT4 T allele carriage (GT+TT genotypes) compared to controls. PMID: 24979672
    50. STAT4 plays a crucial role in the function of innate and adaptive immune cells; dysregulated expression and aberrant activation of STAT4 is observed in many human autoimmune conditions. PMID: 24844303

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  • 相关疾病：
    Systemic lupus erythematosus 11 (SLEB11); Rheumatoid arthritis (RA)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
  • 蛋白家族：
    Transcription factor STAT family
  • 数据库链接：

    HGNC: 11365

    OMIM: 180300

    KEGG: hsa:6775

    STRING: 9606.ENSP00000351255

    UniGene: Hs.735572