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  4. Recombinant Human Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3)

Recombinant Human Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3)

  • 中文名称：
    人SUDS3重组蛋白
  • 货号：
    CSB-YP863997HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SUDS3重组蛋白
  • 货号：
    CSB-EP863997HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SUDS3重组蛋白
  • 货号：
    CSB-EP863997HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SUDS3重组蛋白
  • 货号：
    CSB-BP863997HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SUDS3重组蛋白
  • 货号：
    CSB-MP863997HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SUDS3
  • Uniprot No.：
  • 别名：
    2400003N08Rik; 2410008L21Rik; 45 kDa Sin3 associated polypeptide; 45 kDa Sin3-associated polypeptide; AU067672; FLJ00052; MGC104711; mSds3; RGD1305986; SAP45; SDS3; SDS3, yeast, homolog of; SDS3_HUMAN; Sin3 histone deacetylase corepressor complex component SDS3; Sin3A associated protein 45kDa; Suds3; Suppressor of defective silencing 3; Suppressor of defective silencing 3 homolog (S cerevisiae); Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae); Suppressor of defective silencing 3 protein homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-328
  • 氨基酸序列
    SAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK KLDQQYKERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR KTSDSTKMRI YLGQLQRGLF VIRRRSAA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
  • 基因功能参考文献：
    1. Our results have demonstrated that these hyaluronan binding motifs (HABMs) in USP17 and its substrate SDS3 are mainly involved in the inhibition of anchorage-independent tumor growth. PMID: 22662218
    2. SDS3, being a substrate of USP17, may play an important role in developing a novel therapeutic means to inhibit specific HDAC activities in cancer. PMID: 21239494
    3. the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors PMID: 19070953
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SDS3 family
  • 组织特异性：
    Expressed in various cancer cell ines.
  • 数据库链接：

    HGNC: 29545

    OMIM: 608250

    KEGG: hsa:64426

    STRING: 9606.ENSP00000443988

    UniGene: Hs.416630