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  4. Recombinant Human Sodium channel subunit beta-3 (SCN3B), partial

Recombinant Human Sodium channel subunit beta-3 (SCN3B), partial

  • 中文名称：
    人SCN3B重组蛋白
  • 货号：
    CSB-YP885762HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SCN3B重组蛋白
  • 货号：
    CSB-EP885762HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SCN3B重组蛋白
  • 货号：
    CSB-EP885762HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SCN3B重组蛋白
  • 货号：
    CSB-BP885762HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SCN3B重组蛋白
  • 货号：
    CSB-MP885762HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SCN3B
  • Uniprot No.：
  • 别名：
    1110001K16Rik; 4833414B02Rik; HSA243396; KIAA1158; MGC136997; MGC80155; Scn3b; SCN3B_HUMAN; SCNB3; Sodium channel subunit beta-3; Sodium channel, beta 3 subunit; sodium channel, voltage-gated, type III, beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • 基因功能参考文献：
    1. Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome. PMID: 26179811
    2. In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes. PMID: 25757662
    3. SCN1-3B the gene that encode respectively a- and b-subunits of the cardiac fast voltage-gated sodium channel, have been linked to atrial fibrillation. PMID: 25443231
    4. The Val110Ile mutation of SCN3B is a relatively common cause of SCN5A-negative BrS in Japan, which has a reduced sodium current because of the loss of cell surface expression of Nav1.5. PMID: 23257389
    5. the beta3 subunit can mediate trans homophilic-binding via its Ig domain and the beta3-Ig domain can associate heterophilically with the beta1 subunit PMID: 23118027
    6. three mutations in SCN3B were investigated electrophysiologically and all led to loss of function in the sodium current, supporting the hypothesis that decreased sodium current enhances atrial fibrillation susceptibility PMID: 21051419
    7. The researchers found evidence of an association between SCN3B subunit mutations and sudden infant death syndrome pathogenesis. PMID: 20226894
    8. The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions. PMID: 20675377
    9. This study identifies the first atrial fibrillation(AF) -associated mutation in SCN3B, and suggests that mutations in SCN3B may be a new pathogenic cause of AF. PMID: 20558140
    10. Study provides molecular and cellular evidence implicating mutations in SCN3B as a cause of idiopathic ventricular fibrillation. PMID: 20042427
    11. SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs. PMID: 15334053
    12. In patients with temporal lobe epilepsy, Na(v)beta3 levels were dramatically reduced in the hippocampus, but not in the cortex of non-hippocampal sclerosis patients when compared to hippocampal sclerosis patients. PMID: 19385982
    13. beta3 does not participate in trans homophilic cell-cell adhesion or associate with contactin. PMID: 19596049

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  • 相关疾病：
    Brugada syndrome 7 (BRGDA7); Atrial fibrillation, familial, 16 (ATFB16)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family
  • 组织特异性：
    Expressed in the atrium.
  • 数据库链接：

    HGNC: 20665

    OMIM: 608214

    KEGG: hsa:55800

    STRING: 9606.ENSP00000299333

    UniGene: Hs.4865