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  4. Recombinant Human Sodium-coupled neutral amino acid transporter 1 (SLC38A1), partial

Recombinant Human Sodium-coupled neutral amino acid transporter 1 (SLC38A1), partial

  • 中文名称：
    人SLC38A1重组蛋白
  • 货号：
    CSB-YP880955HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC38A1重组蛋白
  • 货号：
    CSB-EP880955HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC38A1重组蛋白
  • 货号：
    CSB-EP880955HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC38A1重组蛋白
  • 货号：
    CSB-BP880955HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC38A1重组蛋白
  • 货号：
    CSB-MP880955HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Amino acid transporter A1; Amino acid transporter system A1; ATA 1; ATA1; N-system amino acid transporter 2; NAT 2; NAT2; S38A1_HUMAN; SAT 1; SAT1; SLC38A1; SNAT 1; SNAT1; Sodium-coupled neutral amino acid transporter 1; Solute carrier family 38 member 1; System A amino acid transporter 1; System N amino acid transporter 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
  • 基因功能参考文献：
    1. High SNAT1 expression is associated with increased cell migration in breast neoplasms. PMID: 27048259
    2. this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis. PMID: 27613819
    3. Results found that SLC38A1 was up-regulated in colorectal cancer cells (CRC) and significantly associated with tumor invasion and advanced disease stage. Its overexpression enhanced growth and migration of HCT116 cells providing evidence that activation of SLC38A1 may play a critical role in CRC development and progression. PMID: 28224429
    4. The SLC38A1 protein was very low or undetectable in healthy gastric mucosa but strong staining of SLC38A1 protein was found in the cytoplasm in more than half of gastric cancer samples. SLC38A1 knockdown decreased tumor cell proliferation and migration. PMID: 24712400
    5. The cross-talk between Akt signaling and SNAT1 might play a critical role in the development and progression of breast cancer PMID: 23848995
    6. Increased expression of ATA1 is frequent in human hilar cholangiocarcinoma and significantly correlated with the progression of cholangiocarcinoma, suggesting the importance of ATA1 in cancer development and progression. PMID: 20605601
    7. The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders. PMID: 20308991
    8. results suggest that slc38a1 may play a role in the mechanisms underlying the determination of cellular viability in astrocytes through modulation of intracellular ROS generation PMID: 21219957
    9. SNAT1 is a key contributor to system A activity at term. PMID: 20599747
    10. Theses data demonstrate the physiological importance of ATA1 in hepatocarcinogenesis. PMID: 17549407
    11. Report SNAT1 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    12. A possible association between low expression of SNAT1 and suicidal behavior is suggested. PMID: 19442705

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid/polyamine transporter 2 family
  • 组织特异性：
    Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis.
  • 数据库链接：

    HGNC: 13447

    OMIM: 608490

    KEGG: hsa:81539

    STRING: 9606.ENSP00000381634

    UniGene: Hs.533770