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  4. Recombinant Human Solute carrier family 22 member 11 (SLC22A11), partial

Recombinant Human Solute carrier family 22 member 11 (SLC22A11), partial

  • 中文名称：
    人SLC22A11重组蛋白
  • 货号：
    CSB-YP882097HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC22A11重组蛋白
  • 货号：
    CSB-EP882097HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC22A11重组蛋白
  • 货号：
    CSB-EP882097HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC22A11重组蛋白
  • 货号：
    CSB-BP882097HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC22A11重组蛋白
  • 货号：
    CSB-MP882097HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC22A11
  • Uniprot No.：
  • 别名：
    hOAT4; MGC34282; OAT4; Organic anion transporter 4; S22AB_HUMAN; SLC22A11; Solute carrier family 22 (organic anion/urate transporter) member 11; Solute carrier family 22 member 11
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
  • 基因功能参考文献：
    1. The first genome-wide association study for serum uric acid level in Indians revealed association of SLC2A9, SLC22A11 and ABCG2 gene variants at genome wide significance level in Type 2 diabetes patients. PMID: 26902266
    2. modifies placental passage of perfluorinated alkyl acids, may decrease fetal exposure PMID: 26303760
    3. The regulation of hOAT4 activity was mediated by sgk2 acting through Nedd4-2. PMID: 26740304
    4. SLC22A11 at the basal plasma membrane of human placental syncytiotrophoblasts plays a predominant role in the uptake of 16alpha-OH DHEAS for placental estriol synthesis. PMID: 25919187
    5. A common variant of OAT4/SLC22A11 is associated with renal underexcretion type gout in Japanese men. PMID: 24025986
    6. Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11/SLC22A12 locus that presumably influence the activity of OAT4 and URAT1 and risk of gout. PMID: 24360580
    7. When investigating the genes separately, SLC22A11 and SLC2A9 showed a significant interaction, consistent with the former encoding an organic anion/dicarboxylate exchanger, which mediates diuretic transport in the kidney. PMID: 22753387
    8. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. PMID: 20668102
    9. The down-regulation of hOAT4 activity by activation of protein kinase C and the up-regulation of hOAT4 activity by NHERF-1 are mediated through alteration of hOAT4 internalization. PMID: 20140636
    10. Several naturally occurring SNPs encode variant hOAT4s that may impair the renal tubular re-absorption of important drug substrates. PMID: 20015291
    11. elucidation of the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs PMID: 11855680
    12. Glycosylation serves as a means to specifically regulate hOAT4 function in vivo. PMID: 15576633
    13. hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia. PMID: 17229912
    14. The interaction of PDZ proteins with hOAT4 may be cell-specific. In placenta, a different set of interacting proteins from PDZK1 and NHERF1 may be required to modulate hOAT4 activity. PMID: 17602283
    15. The present study demonstrates that hOAT4 variants can causing inter-individual variation in anionic drug uptake and, therefore, could be used as markers for certain diseases including osteoporosis. PMID: 18414001
    16. Findings suggest that hOAT4 and caveolin-1 share a cellular expression in the plasma membrane and caveolin-1 up-regulates the organic anionic compound uptake by hOAT4 under the normal physiological condition. PMID: 18985008

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Detected in placenta and kidney.
  • 数据库链接：

    HGNC: 18120

    OMIM: 607097

    KEGG: hsa:55867

    STRING: 9606.ENSP00000301891

    UniGene: Hs.220844