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  4. Recombinant Human Solute carrier family 23 member 1 (SLC23A1), partial

Recombinant Human Solute carrier family 23 member 1 (SLC23A1), partial

  • 货号：
    CSB-YP887038HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP887038HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP887038HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP887038HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP887038HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC23A1
  • Uniprot No.：
  • 别名：
    hSVCT1; Na(+)/L-ascorbic acid transporter 1; S23A1_HUMAN; Slc23a1; Sodium-dependent vitamin C transporter 1; solute carrier family 23 (nucleobase transporters); member 1; Solute carrier family 23 member 1; SVCT1; Yolk sac permease-like molecule 3; YSPL3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
  • 基因功能参考文献：
    1. consensus site for HNF1 that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity PMID: 25933589
    2. SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis. PMID: 24708273
    3. Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS] PMID: 25527764
    4. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells. PMID: 22990596
    5. A genetic variant in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort. PMID: 24284447
    6. SVCT1 directly interacts with GRHPR. PMID: 23599041
    7. These findings show a role for Rab8a in the physiological function of SVCT1 in intestinal epithelia. PMID: 23014846
    8. A genetic variant (rs33972313) in the SLC23A1 vitamin C active transporter locus was identified that is reliably associated with circulating concentrations of L-ascorbic acid in the general population. PMID: 20519558
    9. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20519558
    10. SVCT1 is the transporter that allows vectorial uptake of ascorbic acid in differentiated CaCo-2 cells PMID: 12381735
    11. Results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity. PMID: 15084584
    12. Findings link genetic variants in the vitamin C transporter gene SLC23A1 to spontaneous preterm birth. PMID: 16357110
    13. C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production PMID: 17008880
    14. We present a transport model for SVCT1 that will provide a framework for investigating the impact of specific mutations and polymorphisms in SLC23A1 and help us better understand the contribution of SVCT1 to vitamin C metabolism in health and disease. PMID: 18094143
    15. The results suggest that uncharged His51 of hSVCT1, directly or indirectly, contributes to substrate binding through the hydrogen bond. PMID: 18247577
    16. SVCT1 may be targeted to facilitate the delivery of drugs with low bioavailability by conjugating with ascorbic acid PMID: 18417304
    17. N-Glycosylation is therefore essential for SVCT1 functionality. PMID: 18619416
    18. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association with colorectal adenoma risk. PMID: 18791929
    19. Results using short interfering RNA suggest that in HepG2 cells, decreasing hSVCT2 message levels reduces the overall ascorbic acid uptake process more than decreasing hSVCT1 message levels. PMID: 18845575
    20. Results describe the membrane topology of human SVCT1 and SVCT2, and the role of glycosylation on protein transport. PMID: 19379732
    21. HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression PMID: 19741195
    22. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18818748

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Xanthine/uracil permease family, Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily
  • 组织特异性：
    Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.
  • 数据库链接：

    HGNC: 10974

    OMIM: 603790

    KEGG: hsa:9963

    STRING: 9606.ENSP00000302851

    UniGene: Hs.643467