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  4. Recombinant Human Somatostatin (SST)

Recombinant Human Somatostatin (SST)

  • 货号：
    CSB-YP022723HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022723HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022723HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022723HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022723HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SST
  • Uniprot No.：
  • 别名：
    Growth hormone release inhibiting factor; Growth hormone release-inhibiting factor; Prepro somatostatin; SMS_HUMAN; SMST; Somatostatin 14; Somatostatin 28; Somatostatin-14; SST
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    89-116
  • 氨基酸序列
    SA NSNPAMAPRE RKAGCKNFFW KTFTSC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.; May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH.
  • 基因功能参考文献：
    1. Temporal changes in levels of circulating SST mirror the temporal changes in the incidence of migraine, particularly in women. The SST2 receptor agonist octreotide has been used with some success in migraine and cluster headache. s suggest that the withdrawal of descending tone in SST-containing neurons, might create a false pain signal and hence the headache of migraine. [Review] PMID: 29751998
    2. By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer PMID: 28119363
    3. Somatostatin pancreatic Delta cells (D cells) locations have also been confirmed in animals and human [review]. PMID: 27977627
    4. Remarkably, the cyclic neuroendocrine peptide somatostatin-14 (SST14) was observed to be the most selectively enriched oligomeric Abeta1-42 binder. PMID: 28650319
    5. This study demonstrated that expression of somatostatin its colocalization with alpha-synuclein in Amygdala in patient with Parkinson disease. PMID: 28859333
    6. These results suggest that the poly-T repeat sequence polymorphism in the promoter of the SST gene is associated with significant variations of blood pressure and could modulate the risk of hypertension, particularly among women. PMID: 26818653
    7. High N-terminal prosomatostatin expression is associated with Cardiovascular Disease and Diabetes. PMID: 27399347
    8. Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin, insulin, glucagon, and somatostatin, and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients. PMID: 26684862
    9. Patients with chronic pancreatitis were found to have a strong immunohistochemical reaction to somatostatin and changes in the distribution of D cells when compared to healthy patients. PMID: 26589890
    10. Results suggest that DNA methylation may be a proximal mechanism for decreased expression of BDNF, SST, and other BDNF- and GABA-related genes with brain aging and, by extension, for brain disorders in which their expression is decreased PMID: 25881116
    11. In cancerous colonic mucosa promoter hypermethylation-related SST downregulation may contribute to the uncontrolled cell proliferation. PMID: 25723531
    12. Aberrant methylation inactivates somatostatin and SSTR1 in head and neck squamous cell carcinoma. PMID: 25734919
    13. Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development. PMID: 24965867
    14. The aim of the study was to provide knowledge on somatostatin and its action on the body, particularly the pancreas - in physiological and pathological conditions--{REVIEW} PMID: 25156131
    15. Somatostatin and insulin together are critical paracrine mediators of glucose-inhibited glucagon secretion and function by lowering cAMP/PKA signaling with increasing glucose. PMID: 25406263
    16. No somatostatin promoter hypermethylation was detected in the Alzheimer neocortex. PMID: 24602981
    17. Hemostatic effects and safety does not differ significantly between somatostatin and octreotide as adjuvants to endoscopic treatment in patients with acute gastroesophageal variceal bleeding. PMID: 24415445
    18. Somatostatin neurons contribute differently to spatial integration. PMID: 23825418
    19. somatostatin limits VEGF release through its interaction with miR-361, indicating that miR-361 participates in the adaptive response of human umbilical vein endothelial cells to hypoxia PMID: 23128854
    20. Somatostatin interneurons-mediated disinhibition represents an important circuit mechanism for cortical information processing. PMID: 23312523
    21. Data suggest that SST-14 inhibits secretion from alpha and beta pancreatic cells by activating GIRK (G protein-coupled inwardly-rectifying potassium channel) and inhibiting exocytosis; these effects are mediated by SST receptor 2 in both cell types. PMID: 22932785
    22. Investigation of the healthy human pylorus shows characteristic distribution of cells that react with antisera to gastrin and somatostatin. PMID: 22532184
    23. PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-beta3 (PLC-beta3)-specific activation of somatostatin by forming a ternary complex with PLC-beta3 and somatostatin receptors. PMID: 22528496
    24. role played by somatostatin in preventing Abeta accumulation by partially restoring IDE activity PMID: 22509294
    25. Somatostatin neurons hyperpolarized and reduced action potential firing in response to both passive and active whisker sensing, in contrast with all other recorded types of nearby neurons in transgenic mice. PMID: 22366760
    26. Alterations in SST signaling and/or SST-bearing GABA neurons may represent a critical pathophysiological entity that contributes to singulate cortex dysfunction and that matches to the high female vulnerability to develop major depressive disorder. PMID: 21232602
    27. somatostatin inhibits the neuropeptide Y response to hypoglycemia PMID: 21640760
    28. somatostatin suppresses GH activity in peripheral tissues PMID: 21632809
    29. Synchronous firing strength correlates with, and is dependent on, unidirectional or reciprocal GABAergic synapses between electrically coupled fast-spiking and somatostatin-containing inhibitory interneuron subtypes in transgenic mice. PMID: 21368047
    30. SST, presumably via SSTR3/MUPP1, regulates tight junction permeability in cultured keratinocytes PMID: 20629740
    31. Mean value of serum somatostatin at baseline was significantly increased in Parkinson's disease patients compared with the control group (P < 0.01) PMID: 20055772
    32. Data show an increasing tendency in the expressions of GAS and SS in children with chronic gastritis and duodenal ulcer. PMID: 17229384
    33. Increased MCT1 association with CD147 at the apical membrane in response to somatostatin (SST) is p38 MAP kinase dependent and underlies the stimulatory effects of SST on butyrate uptake in human intestinal epithelial cells. PMID: 20501436
    34. somatostatin decreases in Alzheimer's disease and its expression may be linked with Abeta deposition PMID: 19559700
    35. down-regulated KLF4, CHGA, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA is an 8-gene signature for gastric cancer PMID: 20043075
    36. Our results supported the notion that the C allele of the rs4988514 polymorphism may increase the risk for AD in the Chinese population and possibly have additive effect with the APOE epsilon4 allele. PMID: 19733630
    37. A critical analysis is made of the structure and physiology of SST and its receptors, and the possible role it plays in cell proliferation in animal models and the treatment of human tumors. PMID: 11753230
    38. The somatostatin-28 (S-28) NPAMAP peptide sequence constitutes an accurate alpha-helix nucleation motif allowing for the generation of equal amounts of S-28 and somatostatin-14 from their common precursor in cultured cells. PMID: 11814357
    39. Somatostatin acts as a selective chemoattractant for immature hematopoietic cells PMID: 11823046
    40. Structural motifs in the somatostatin precursor PMID: 11860030
    41. Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2. PMID: 11920268
    42. present in human colorectal adenocarcinomas and liver metastases PMID: 12174892
    43. somatostatin receptor 2 mRNA was selectively expressed, somatostatin mRNA was not detectable, and cortistatin mRNA was expressed in all samples of monocytes monocyte-derived macrophages, and dendritic cells in basal and lipopolysaccharide-activated state PMID: 12684217
    44. somatostatin has a role in inhibiting ERK 1/2 signaling and the PI3-K pathway via the inhibition of Rac in SHSY5Y cells PMID: 12902325
    45. Fasting but not postprandial hypersomatostatinemia, mainly due to an increase in SS-14, characterizes acromegaly. Excess GH/IGF-I could be a causal factor in somatostatin hypersecretion. PMID: 12952361
    46. Reduced ghrelin, impaired growth hormone(GH) response to GHRH by excess FFA, and increased somatostatin tone contribute to reduced GH secretion in patients with HIV-lipodystrophy. PMID: 14559725
    47. High concentration of somatostatin (SST) in respiratory centers of fetal brainstems correlates with its involvement in the inhibition of intrauterine breathing. PMID: 15266779
    48. SST acts both centrally and peripherally to control the GH-IGF-I axis. PMID: 15286801
    49. certain bioactive peptides such as somatostatin and substance P directly interact with human P-glycoprotein as endogenous substrates for P-glycoprotein-mediated transport PMID: 15358539
    50. human visceral adipose tissue secretes SRIF during inflammation and sepsis PMID: 15472172

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Somatostatin family
  • 数据库链接：

    HGNC: 11329

    OMIM: 182450

    KEGG: hsa:6750

    STRING: 9606.ENSP00000287641

    UniGene: Hs.12409