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  4. Recombinant Human Spermatogenesis-associated protein 13 (SPATA13)

Recombinant Human Spermatogenesis-associated protein 13 (SPATA13)

  • 货号：
    CSB-YP842724HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP842724HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP842724HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP842724HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP842724HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    APC-stimulated guanine nucleotide exchange factor 2; ARHGEF29; Asef2; FLJ31208; RP11-307N16.3; Spata13; Spermatogenesis-associated protein 13; SPT13_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-652
  • 氨基酸序列
    MTSASPEDQN APVGCPKGAR RRRPISVIGG VSLYGTNQTE ELDNLLTQPA SRPPMPAHQV PPYKAVSARF RPFTFSQSTP IGLDRVGRRR QMRASNVSSD GGTEPSALVD DNGSEEDFSY EDLCQASPRY LQPGGEQLAI NELISDGNVV CAEALWDHVT MDDQELGFKA GDVIQVLEAS NKDWWWGRSE DKEAWFPASF VRLRVNQEEL SENSSSTPSE EQDEEASQSR HRHCENKQQM RTNVIREIMD TERVYIKHLR DICEGYIRQC RKHTGMFTVA QLATIFGNIE DIYKFQRKFL KDLEKQYNKE EPHLSEIGSC FLQNQEGFAI YSEYCNNHPG ACLELANLMK QGKYRHFFEA CRLLQQMIDI AIDGFLLTPV QKICKYPLQL AELLKYTTQE HGDYSNIKAA YEAMKNVACL INERKRKLES IDKIARWQVS IVGWEGLDIL DRSSELIHSG ELTKITKQGK SQQRTFFLFD HQLVSCKKDL LRRDMLYYKG RLDMDEMELV DLGDGRDKDC NLSVKNAFKL VSRTTDEVYL FCAKKQEDKA RWLQACADER RRVQEDKEMG MEISENQKKL AMLNAQKAGH GKSKGYNRCP VAPPHQGLHP IHQRHITMPT SVPQQQVFGL AEPKRKSSLF WHTFNRLTPF RK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
  • 基因功能参考文献：
    1. Phosphorylation of S106 modulates Asef2 guanine nucleotide exchange factor activity and Asef2-mediated cell migration and adhesion turnover. PMID: 24874604
    2. A new role for Rac activation, promoted by Asef2, in modulating actomyosin contractility. PMID: 24144700
    3. Asef2 activates Rac1 to modulate adhesion and actin dynamics and thereby regulate cell migration. PMID: 19934221
    4. These results suggest that similar to Asef, Asef2 plays an important role in cell migration, and that Asef2 activated by truncated mutant APC is required for aberrant migration of colorectal tumor cells. PMID: 17599059
    5. Asef2, Neurabin2 and APC cooperatively regulate actin cytoskeletal organization and are required for HGF-induced cell migration. PMID: 19151759
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 19910543

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  • 亚细胞定位：
    Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
  • 组织特异性：
    Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.
  • 数据库链接：

    HGNC: 23222

    OMIM: 613324

    KEGG: hsa:221178

    STRING: 9606.ENSP00000371542

    UniGene: Hs.434298