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  4. Recombinant Human Stathmin (STMN1)

Recombinant Human Stathmin (STMN1)

  • 货号：
    CSB-YP022857HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022857HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022857HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022857HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022857HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    C1orf215; Lag; LAP 18; LAP18; Leukemia associated phosphoprotein p18; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; Op18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; pp17; pp19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1; Stmn1; STMN1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-149
  • 氨基酸序列
    ASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
  • 基因功能参考文献：
    1. these data indicate that activation of autophagy reduces expression of STMN1 and p53, and the migration and invasion of cancer cells contributes to the anti-cancer effects of the Halofuginone. These findings may provide new insight into breast cancer prevention and therapy. PMID: 29231257
    2. Low expression of STMN1 was found in 43.62%, and high expression of STMN1 was found in 56.38% of cases of osteosarcoma. High tumor expression of STMN1 was a prognostic marker for poor prognosis, poor response to chemotherapy, the presence of metastases, advanced Enneking surgical stage and the chondroblastic osteosarcoma subtype. The expression STMN1 was identified as an independent prognostic biomarker of osteosarcoma . PMID: 30169496
    3. a transcription-independent mechanism for Stat3-mediated centrosome clustering that involves Stathmin, a Stat3 interactor involved in microtubule depolymerization, and the mitotic kinase PLK1, is reported. PMID: 28474672
    4. Results suggest that stathmin is essential in bipolar spindle formation to maintain genomic stability during mitosis, and the depletion of stathmin prevents the initiation of chromosome instability by inducing senescence in human normal fibroblasts. PMID: 28885720
    5. Results showed that STMN1 overexpression was significantly associated with lymphatic metastatic recurrence in pN0 esophageal squamous cell carcinoma (ESCC) patients. STMN1 levels are regulated by the PI3K pathway, and STMN1 can act as a surrogate marker of PI3K pathway signaling related to tumor recurrence. PMID: 29251330
    6. The investigation confirmed that stathmin expression was correlated with more aggressive behavior of cervical cancer. PMID: 29953794
    7. High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma. PMID: 28933054
    8. STMN1 expression was significantly associated with prognosis and tumour differentiation in ESCC, indicating that STMN1 expression is an independent prognostic factor for ESCC and could be a potential biomarker. Regulating the expression of STMN1 could influence tumour cell motility, invasion and proliferation PMID: 29039594
    9. T3-mediated suppression of STMN1 supports the theory that T3 plays an inhibitory role in HCC tumor growth, and suggests that the lack of normal THR function leads to elevated STMN1 expression and malignant growth PMID: 27934948
    10. These results suggest that stathmin acts as an oncogene and is transcriptionally regulated by mutant p53, but not by wild-type p53. Stathmin could be a potential anti-tumor therapeutic target in oral squamous cell carcinoma PMID: 28806997
    11. Results suggest that Stathmin 1 (STMN1) plays an important role in cell proliferation and migration. PMID: 27349455
    12. STMN1 expression was higher in basal-type cell lines than in luminal-type cell lines, and overall survival and post-progression survival in the high STMN1 expression breast cancer patients were shorter than in low STMN1 expression patients. High STMN1 expression is a possible marker of breast cancer aggressiveness in association with proliferation, phenotype and cancer stem cell type PMID: 28766688
    13. we found upregulated expression of STMN1 in the atypical/anaplastic meningioma group, relative to that in the benign meningioma group. STMN1, therefore, is a promising target to improve cure rates in meningioma cases. PMID: 28625575
    14. An increased risk of sporadic atypical meningioma recurrence can be found in cases with elevated expression of STMN1. PMID: 28622584
    15. The miR-34a/STMN1/betaIII-tubulin axis maintains the microtubule cytoskeleton in osteosarcoma, and combining miR-34a with microtubule inhibitors can be investigated as a novel therapeutic strategy. PMID: 28275089
    16. These findings suggest that Cdc2 is positively associatd with the development of taxol resistance. The Cdc2 inhibitor, purvalanol A, enhanced the cytotoxic effects of taxol through Op18/stathmin. PMID: 28534969
    17. these results showed that stathmin expression was significantly up-regulated in LAC, which may act as a biomarker for LAC. Furthermore, silence of stathmin inhibiting LAC cell growth indicated that stathmin may be a promising molecular target for LAC therapy. PMID: 27494889
    18. Increased stathmin correlated with pathologic grade, lymphatic invasion, advanced stage and poor survival of non-small cell lung cancer (NSCLC), which indicated that stathmin could serve as a potential biomarker of NSCLC PMID: 28282798
    19. Results showed that patients with cancer displayed a higher stathmin expression than those of non-cancer individuals, and overexpression of stathmin correlated with tumor cell differentiation, lymph node invasion and high TNM stage. [review] PMID: 27806343
    20. High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Pancreatic Cancer. PMID: 29374725
    21. miR-223 might serve as an onco-suppressor that enhances susceptibility to docetaxel by downregulating STMN1 in gallbladder cancer, highlighting its promising therapeutic value. PMID: 27577078
    22. overexpression correlates with poorer prognosis and interacts with p53 in oral squamous cell carcinoma PMID: 27591090
    23. study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells PMID: 28834690
    24. STMN1 gene and miRNA-223 expression profiles in non-tumor liver tissues were predictive of the risk for multicentric hepatocellular carcinoma recurrence. PMID: 28982915
    25. The crucial role of FOXM1 and STMN1 in TKI-induced enrichment of CSC and drug resistance was demonstrated by knockdown of STMN1 and FOXM1 in NSCLC cells. PMID: 28850563
    26. Our finding demonstrates that RSK2 directly phosphorylates stathmin and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2-stathmin pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers. PMID: 27041561
    27. stathmin expression was significantly associated with shorter progression-free survival and overall survival for all analyzed cases of endometrial cancer; findings demonstrate that high stathmin expression is a poor prognostic marker in endometrial cancer PMID: 28532857
    28. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in gastric cancer (GC) and could be a novel therapeutic target in metastatic GC. PMID: 28334732
    29. STMN1,COF1 and PAIRBP1 thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 and POSTN were connected to low grade tumors with better prognosis PMID: 28216224
    30. The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis. PMID: 27130664
    31. hese results suggested that STMN1 plays an important role in proliferation and migration of hypopharyngeal squamous cell carcinoma and may be used as a potential prognostic biomarker or therapeutic target of hypopharyngeal squamous cell carcinoma (HSCC) . PMID: 27878293
    32. High STMN1 expression is associated with invasion in endometrial carcinoma. PMID: 26815505
    33. High expression of stathmin 1 predicts poor outcome in oral squamous cell carcinoma patients treated by docetaxel-containing regimens. PMID: 26590596
    34. The expressions of TYMS, TUBB3 and STMN1 were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM staging in patients with gastric cancer. PMID: 28056823
    35. Stathmin is a highly sensitive and specific biomarker for the diagnosis of vulvar high-grade squamous intraepithelial lesions. PMID: 27226646
    36. STMN1 silencing by siRNA may enhance the sensitivity of esophageal cancer cells Eca-109 to paclitaxel and induce apoptosis. PMID: 26782519
    37. SNP in STMN1 gene may have a potential predictive role in taxane-based chemotherapy in advanced non-small cell lung cancer. PMID: 26148901
    38. After silencing stathmin-1 in gastric cancer cells, the resistance index was reduced. PMID: 26802649
    39. Results show that the STMN1-E/P/C signature is a reliable prognostic indicator for luminal subtype breast cancer and may predict the therapeutic response to paclitaxel-based treatments, potentially facilitating individualized management. PMID: 26087399
    40. STMN1 may play an important role in the development and tumor progression of cutaneous squamous cell carcinoma PMID: 26235036
    41. Studies indicate that phosphorylation of stathmin controls its biological activity by reducing its affinity for tubulin and hence preventing microtubule disassembly. PMID: 26450904
    42. FANCC interacts and co-localizes with STMN1 at centrosomes during mitosis. We also showed that FANCC is required for STMN1 phosphorylation. PMID: 26466335
    43. PDAC patients with higher STMN1 expression died sooner than those with lower STMN1 expression. PMID: 25791566
    44. stathmin-1 may play a key role in regulating trophoblast invasion PMID: 26272359
    45. These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 upregulation in Hodgkin lymphoma. PMID: 26000982
    46. miR-223 regulates STMN1 in malignant pleural mesothelioma, and both are in turn regulated by the JNK signaling pathway. As such, miR-223 and STMN1 play an important role in regulating MPM cell motility. PMID: 25824152
    47. Report that STMN1 is a highly sensitive marker for leiomyosarcoma but is suboptimally specific for diagnostic purposes. PMID: 26045786
    48. MiR-101 sensitizes human nasopharyngeal carcinoma cells to radiation by targeting stathmin 1 PMID: 25607713
    49. High level of stathmin exhibited poor response to chemotherapy (for mRNA, P = 0.041; for protein, P = 0.017). Overexpression of stathmin was associated with shorter overall survival (for mRNA, P = 0.012) and progression-free survival PMID: 25894372
    50. STMN1 overexpression is associated with drug resistance in esophageal squamous cell carcinoma. PMID: 25944168

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Stathmin family
  • 组织特异性：
    Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at subs
  • 数据库链接：

    HGNC: 6510

    OMIM: 151442

    KEGG: hsa:3925

    STRING: 9606.ENSP00000410452

    UniGene: Hs.209983