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  4. Recombinant Human Steroid hormone receptor ERR1 (ESRRA)

Recombinant Human Steroid hormone receptor ERR1 (ESRRA)

  • 货号：
    CSB-YP007834HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007834HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007834HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007834HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Err 1; ERR a; ERR alpha; ERR-alpha; Err1; ERR1 protein; ERR1_HUMAN; ERRa; ERRalpha; ESRL 1; ESRL1; ESRR A; Esrra; Estrogen receptor like 1; Estrogen receptor related 1; estrogen receptor related receptor alpha; Estrogen receptor-like 1; Estrogen related receptor alpha; Estrogen-related receptor alpha; Estrra; hERR1; NR3B1; Nuclear receptor subfamily 3 group B member 1; Steroid hormone receptor ERR1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-423
  • 氨基酸序列
    MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH KEEEDGEGAG PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT AAPVNALVSH LLVVEPEKLY AMPDPAGPDG HLPAVATLCD LFDREIVVTI SWAKSIPGFS SLSLSDQMSV LQSVWMEVLV LGVAQRSLPL QDELAFAEDL VLDEEGARAA GLGELGAALL QLVRRLQALR LEREEYVLLK ALALANSDSV HIEDAEAVEQ LREALHEALL EYEAGRAGPG GGAERRRAGR LLLTLPLLRQ TAGKVLAHFY GVKLEGKVPM HKLFLEMLEA MMD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
  • 基因功能参考文献：
    1. The present data indicated that ERRa acted as an oncogene in colon cancer cells, and the combined targeting of ERRa and MEK might be a promising therapeutic strategy for colon cancer treatment PMID: 30185207
    2. This work reveals a molecular mechanism by which ERRalpha-induced metabolic reprogramming promotes survival of lapatinib-resistant cancer cells. PMID: 27402251
    3. data showed that activation of NF-kappaB/IL-6 is involved in ERRalpha induced migration and invasion of non-small cell lung cancer cells; it suggested that ERRalpha might be a potential target for non-small cell lung cancer treatment PMID: 29862528
    4. Results show that ERRA is an interacting partner of PGC1a in a subset of human melanoma cells. Also, ERRA promotes mitochondrial oxidative metabolism in melanoma cells. PMID: 28596418
    5. LSD1 and ERRalpha coregulate several target genes involved in cell migration, including the MMP1 matrix metallo-protease, also activated through H3K9 demethylation at the transcriptional start site. PMID: 28348226
    6. TGF-beta treatment can trigger the epithelial-mesenchymal transition of osteosarcoma cells via ERRalpha/Snail pathways. PMID: 27532429
    7. LC3B and ESRRA might be a useful prognostic factor in patients with muscle-invasive bladder cancer. The co-expression of LC3B and ESRRA might be a prognostic and therapeutic target for patients with bladder cancer. PMID: 29599373
    8. These findings indicate that ERRalpha may serve as a novel molecular target for the treatment of endometrial cancer PMID: 27153547
    9. Gls is a novel ERRalpha target gene. PMID: 27501743
    10. can trigger the proliferation and migration of colorectal cancer cells via up regulation of IL-8 PMID: 28993941
    11. curcumin suppressed the ERRalpha gene expression through upregulation of miR-125a. Data from this study revealed a novel mechanism for curcumin-mediated apoptotic cell death, which involves tumor cell killing via activating miR-125a/ERRalpha pathway. PMID: 27231954
    12. blocking the ERRalpha-controlled mitochondrial program largely inhibits the PLA2R1-induced tumor-suppressive response. Together, our data document ERRalpha and its mitochondrial program as downstream effectors of the PLA2R1-JAK2 pathway leading to oncosuppression. PMID: 27041564
    13. results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRalpha expression, resulting in increased cell invasion capacities. PMID: 27227989
    14. HO-1-derived CO enhances mitochondrial biogenesis in astrocytes by activating L-type Ca(2+) channel-mediated PGC-1alpha/ERRalpha axis, leading to maintenance of astrocyte function and neuroprotection/recovery against damage of brain function PMID: 27639646
    15. in ERalpha negative breast cancer, the low level of ERalpha reduced miR-497 expression, which promoted ERRalpha expression that enhanced cell proliferation, migration, and invasion by increasing MIF expression and MMP9 activity. PMID: 27456360
    16. these data show that ERRalpha expression predicts response to tamoxifen treatment, and ERRalpha could be a biomarker of tamoxifen sensitivity and a prognostic factor in TNBC. PMID: 26542058
    17. ERRalpha suppression inhibits angiogenesis in HUVECs PMID: 26586335
    18. Incomplete autophagy and cell death by a necrotic processes, as a consequence of the cell energy failure, induced by pharmacological reduction of ERRalpha in adrenocortical carcinoma cells. PMID: 26312764
    19. CD68(+)CD163(+) macrophages secreted cytokines, such as IL17A, that upregulated ERalpha expression. PMID: 26744532
    20. Inhibition of ERRalpha suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin. PMID: 26160845
    21. mediates metabolic transition, which is required for induced pluripotency PMID: 25865501
    22. An ERRalpha 23-repeats polymorphisms with BMD in postmenopausal Egyptian women. PMID: 25903400
    23. Over-expression of ESRRA due to its gene amplification in OSCC PMID: 26639757
    24. targeting of ERRalpha and pathways regulating transcriptional HIF-2alpha are promising therapeutic avenues in neuroblastoma PMID: 25912138
    25. ERRalpha promoted the migration and invasion of A549 cells by inducing EMT, and Slug was involved in the process. Targeting ERRalpha might be an efficient approach for lung cancer treatment. PMID: 25480584
    26. control exerted by ERRalpha on RHOA stability is required for directional migration PMID: 25288732
    27. These results suggest ERRalpha activation as a mechanism of tumor aggressiveness and imply that targeting ERRa may be a promising approach in ovarian cancer treatment. PMID: 24419103
    28. this study demonstrated that ERR alpha plays an important role in the development of MTX resistance through blocking MTX-induced ROS production and attenuating the activation of p53 mediated apoptosis signaling pathway PMID: 24967384
    29. Estrogen receptor alpha coupled to the Bmi1 regulation pathway plays an important role in breast cancer progression. PMID: 24559156
    30. miR-125a post-transcriptionally regulates ESRRA in oral squamous cell carcinoma PMID: 25266720
    31. The frequency of the ESRRA/C11orf20 gene fusion in serous ovarian carcinomas of stages III and IV must be very low. PMID: 24504521
    32. Cell cycle dependent oscillatory expression of estrogen receptor-alpha links Pol II elongation to neoplastic transformation. PMID: 24979764
    33. ERRalpha is downregulated in uterosacral ligaments in pelvic organ prolapse PMID: 23700042
    34. ERRalpha can promote the hypoxic growth adaptation of prostate cancer cells via a protective interaction with HIF-1alpha, suggesting ERRalpha as a potential therapeutic target for cancer treatment. PMID: 24425001
    35. Data indicate that a stable cell clones have an intact peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha)/estrogen-related receptor alpha (ERRalpha) axis can be used to detect environmental chemicals that act on the signaling pathway. PMID: 24457025
    36. There are 3 ERRalpha response elements (ERR response element, ERRE) in the osteocalcin promoter, and ERRalpha interacted cooperatively with PGC-1alpha could improve the osteocalcin promoter activity. PMID: 23788330
    37. analysis of twenty members across three generations identified a rare missense mutation in the estrogen-related receptor alpha (ESRRA) gene that segregated with eating disorders PMID: 24216484
    38. ERRalpha coordinates colon cancer cell proliferation and tumorigenic capacity with energy metabolism. PMID: 23720198
    39. analysis of clinical datasets from liver tissues showed a negative correlation between expressions of ERRalpha and PTEN in patients with liver cancer. PMID: 23836899
    40. the expression of ERRalpha mRNA was significantly increased during the late stage of osteogenic differentiation of human periodontal ligament tissue-derived mesenchymal stem cells. PMID: 23525223
    41. ERRa and OPN are co-expressed and higher in colorectal cancer cells as opposed to normal mucosa. Data provide compelling evidence that OPN is a direct target of ERRa, the induction of which could clearly contribute to colorectal cancer pathogenesis. PMID: 23680656
    42. ERRalpha can act as a transcriptional activator of Runx2-I in presence of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1alpha). PMID: 23403054
    43. the role played by ERRalpha in the regulation of lactate dehydrogenases A and B PMID: 23516535
    44. A possible role of ERRalpha in adrenal development and adrenocortical carcinoma. PMID: 23123734
    45. ERRalpha and PGC-1beta are key players in the etiology of breast cancer by coordinating the transcriptional regulation of genes located in the 17q12 region, a process that also involves interference with the repressive function of ERalpha on ERBB2 expression. PMID: 20961995
    46. Data identify ERRalpha as a new regulator of the Wnt-signaling pathway during osteoblast differentiation, through a cell-intrinsic mechanism not affecting beta-catenin nuclear translocation. PMID: 22333182
    47. ERRalpha-induced adipogenesis is triggered by modulating the expression of PGC-1beta. PMID: 21732060
    48. Data observed in DMD and aging skeletal muscle enrichment in motifs for candidate transcription factors that may coordinate either the immune/fibrosis responses (ETS1, IRF1, NF1) or the mitochondrial metabolism (ESRRA). PMID: 22096509
    49. these data suggest that RaRF sequesters ERRalpha in the nucleolus through a specific interaction, thereby inhibiting its transcriptional activity. PMID: 22266318
    50. Exposure to XCT790, a synthetic inverse agonist of the orphan nuclear oestrogen-related receptor alpha (ERRalpha), also induced EGFR and HB-EGF expression to the same extent as AM251. PMID: 21449913

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 数据库链接：

    HGNC: 3471

    OMIM: 601998

    KEGG: hsa:2101

    STRING: 9606.ENSP00000000442

    UniGene: Hs.110849