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  4. Recombinant Human Stromelysin-2 (MMP10)

Recombinant Human Stromelysin-2 (MMP10)

  • 货号：
    CSB-BP014657HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-EP014657HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-MP014657HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MMP10
  • Uniprot No.：
  • 别名：
    Matrix metallopeptidase 10 (stromelysin 2); Matrix metalloprotease 10; Matrix metalloproteinase 10 (stromelysin 2); Matrix metalloproteinase 10; Matrix metalloproteinase-10; MMP 10; MMP-10; Mmp10; MMP10_HUMAN; SL 2; SL-2; SL2; STMY 2; STMY2; Stromelysin 2; Stromelysin II; Stromelysin-2; Stromelysin2; StromelysinII; Transin 2; Transin-2; Transin2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    99-476aa
  • 氨基酸序列
    FSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
  • 基因功能参考文献：
    1. increased abundance of Snail and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development PMID: 28939077
    2. MMP10, either alone or in combination with tPA, might represent a new strategy for thrombolysis in ischemic stroke, providing higher protection against cerebrovascular damage. PMID: 28379489
    3. There is a significant association in the expression of P-Rex1 and MMP10 in human luminal breast cancer, and their co-expression is indicative of poor prognosis. PMID: 27351228
    4. MMP10 is a novel marker for cancer stem-like cells (CSCs)/cancer-initiating cells in epithelial ovarian cancer PMID: 27072580
    5. Data show that AJUBA upregulated MMP10 and MMP13 expression in esophageal squamous cell carcinoma (ESCC). PMID: 27172796
    6. MMP10 is overexpressed in the serum and pulmonary arteries of patients with systemic sclerosis-associated pulmonary hypertension. PMID: 28805015
    7. Using a quantum chemical approach method, it has been established that mutations in MMP-10 and FGA proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients. PMID: 29016666
    8. These results indicate that MMP10 serves a beneficial role in response to acute infection by moderating the proinflammatory response of resident and infiltrating macrophages. PMID: 27316687
    9. Mycobacterium tuberculosis activates inflammatory and stromal cells to secrete MMP-10, and this is partly driven by the virulence factor early secretory antigenic target-6. PMID: 27654284
    10. MMP10 expression is significantly upregulated in human masticatory mucosa during wound healing. PMID: 28005267
    11. Our results suggest that the level of the MMP-10 expression in tumor epithelium of cutaneous squamous cell carcinoma and basal cell carcinoma may contribute to the different invasive patterns observed in these tumors PMID: 27567711
    12. these results suggest that TGF-beta1 stimulates HSC-4 cell invasion through the Slug/Wnt-5b/MMP-10 signalling axis. PMID: 26861993
    13. the rs17435959 polymorphism of the MMP-10 gene may be associated with an increased risk of pelvic organ prolapse (POP). PMID: 26419737
    14. According to this study, the expression of ST-2 is associated with histopathological grade and tumor differentiation in head and neck squamous cell carcinomas. PMID: 26625808
    15. MMP-10 may be a novel biomarker reflecting both disease severity and prognosis in patients with idiopathic pulmonary fibrosis. PMID: 26415518
    16. Noncomplicated PVVs are associated with systemic, prothrombotic activation of hemostasis and increased concentration of MMP-10, suggesting a prothrombotic and proinflammatory state. PMID: 24413984
    17. Up-regulation of matrix metalloproteinase 10 is associated with colitis-associated cancer. PMID: 25742789
    18. hepatocellular carcinoma cells stably expressing MMP10 had increased CXCR4 expression and migratory capacity PMID: 25808184
    19. No association was found between MMP10 C/T rs486055 variants and anterior cruciate ligament rupture. PMID: 21410539
    20. Suggest that MMP-10 is associated with severity and poor outcome in peripheral arterial disease. PMID: 25441671
    21. Taken together, our findings show that MMP-10 can play a significant role in tumor growth and progression, and that MMP-10 perturbation may represent a rational strategy for cancer treatment. PMID: 24885595
    22. YY1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. PMID: 24884523
    23. Preliminary evidence suggests that MMP-10 may be a mediator of the number of depressive phases during bipolar disorder PMID: 24576976
    24. Chrysin downregulates matrix metalloproteinase-10 in triple-negative breast cancer cells. PMID: 24122885
    25. Data suggest that MMP10 promotes differentiation of myoblasts into osteoblasts by up-regulating BMP2/Smad6/Smad7 (bone morphogenetic protein 2) signaling pathway and gene expression of proteins found in bone (collagen, type I; osterix; osteocalcin). PMID: 24077220
    26. MMP-10 is involved in the development of microvascular complications in type 1 diabetes and emerges as a potential therapeutic target for slowing down the evolution of diabetic nephropathy and retinopathy. PMID: 24078057
    27. Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells. PMID: 24009192
    28. rs17435959 of the MMP-10 gene is associated with carotid vulnerable plaque. PMID: 24327153
    29. serum proMMP-10 after acute ischemic stroke is associated with TNFalpha and may have a role in brain damage and poor outcome PMID: 23742289
    30. Small hairpin RNA silencing of proteinases overexpressed in diabetic corneas enhanced corneal epithelial and stem cell marker staining and accelerated wound healing. PMID: 24255036
    31. COOH truncation of the hepatitis B virus X protein, plays a role in enhancing cell invasiveness and metastasis in hepatocellular carcinoma by activating MMP10 through C-Jun. PMID: 22821423
    32. Findings suggest that MMP10 plays an important role in esophageal squamous cell carcinoma progression in the early stage, and overexpression of MMP10 in tumor tissues could be used as a potential prognostic marker in the early clinical stage of ESCC. PMID: 22121946
    33. High MMP-10 is associated with malignant pleural effusion. PMID: 22524815
    34. Analysis of gene expression data from human cancers reveals a strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. PMID: 22545096
    35. Data show that TIMP-1 inhibits the MMP-10 with a K(i) of 1.1 x 10(-9) M, and TIMP-2 inhibits the MMP-10 with a K(i) of 5.8 x 10(-9) M. PMID: 22427646
    36. Thrombin/CD40L elicited a strong synergistic effect on endothelial MMP-10 expression and microparticles containing MMP-10 in vitro and in vivo, which may represent a new link between inflammation/thrombosis with prognostic implications. PMID: 22492089
    37. MMP-10 was capable of enhancing tissue plasminogen activator-induced fibrinolysis via a thrombin-activatable fibrinolysis inhibitor inactivation-mediated mechanism. PMID: 22104553
    38. the roles of MMP-10 in the invasion of head and neck squamous cell carcinoma cells in vitro PMID: 21998657
    39. Mmp10 is overexpressed in lung tumors induced by either the smoke carcinogen urethane or oncogenic Kras. PMID: 22022614
    40. Enhanced expression of MMP-10 is associated with progression from non-dysplastic Barrett's oesophagus to adenocarcinoma. PMID: 20584750
    41. Data demonstrate induction of MMP-10 by VEGF in HUVEC and support an angiogenic role for MMP-10 in response to VEGF stimulation in vitro and in vivo. PMID: 20432469
    42. Results suggest that MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. PMID: 19601983
    43. MMP-10 and MMP-26, in particular, may associate with aggressive Merkel cell carcinoma. PMID: 19921252
    44. The catalytic domain of human matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 angstroms resolution. PMID: 15095982
    45. Beta-carotene suppresses UVA-induction of MMP-10. PMID: 15288123
    46. a tightly regulated expression level of stromelysin-2 is required for limited matrix degradation at the wound site PMID: 15371548
    47. Overexpression of MMP-10 is associated with non-small cell lung cancer PMID: 15375490
    48. identified significant interactions between MMP10 (nt+180) polymorphisms and gender in abdominal aortic aneurysm PMID: 15944607
    49. zinc finger protein 267 as a negative transcriptional regulator of MMP-10 might promote liver fibrogenesis PMID: 16054593
    50. Increased levels of MMP-10 is associated with gastric cancer PMID: 16331256

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 数据库链接：

    HGNC: 7156

    OMIM: 185260

    KEGG: hsa:4319

    STRING: 9606.ENSP00000279441

    UniGene: Hs.2258