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  4. Recombinant Human Sulfate transporter (SLC26A2), partial

Recombinant Human Sulfate transporter (SLC26A2), partial

  • 中文名称：
    人SLC26A2重组蛋白
  • 货号：
    CSB-YP021525HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC26A2重组蛋白
  • 货号：
    CSB-EP021525HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC26A2重组蛋白
  • 货号：
    CSB-EP021525HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC26A2重组蛋白
  • 货号：
    CSB-BP021525HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC26A2重组蛋白
  • 货号：
    CSB-MP021525HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC26A2
  • Uniprot No.：
  • 别名：
    SLC26A2; DTD; DTDST; Sulfate transporter; Diastrophic dysplasia protein; Solute carrier family 26 member 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sulfate transporter. May play a role in endochondral bone formation.
  • 基因功能参考文献：
    1. Two heterozygous mutations in SLC26A2 mutations occur in a three-generational family with cases of multiple epiphyseal dysplasias. PMID: 29024831
    2. Results show that SLC26A2 expression is high in numerous tumor types and, provide evidence that it downregulates the TRAIL receptors, DR4 and DR5 which confers resistance to TRAIL. PMID: 28108622
    3. slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment PMID: 26375458
    4. findings provide the first identification of autosomal dominant SLC26A2 mutations in patients with dysplastic spondylolysis, suggesting a new clinical entity in the pathogenesis of chondrodysplasia involving lumbosacral spine PMID: 26077908
    5. Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion. PMID: 24591336
    6. Up-regulation of SLC26A2 is associated with colorectal cancer. PMID: 24222123
    7. A compound heterozygote SLC26A2 mutation is associated with robin sequence, mild limbs shortness, accelerated carpal ossification, and multiple epiphysial dysplasia PMID: 23840040
    8. SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively. PMID: 23453247
    9. 73% of autosomal-recessive multiple epiphyseal dysplasia patients were either homozygous, or compound heterozygous, for SLC26A2 mutations. PMID: 21922596
    10. Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula/OH-/Cl- exchanger regulated b PMID: 22190686
    11. Mutations in the SLC26A2 gene causes diastrophic dysplasia. PMID: 21155763
    12. Analysis suggests that, while the DTDST family of disorders contains at least seven different conditions, gene mutations appear to cause a phenotypic continuum. DTDST genotype alone is an imperfect predictor of clinical severity along this continuum. PMID: 21077202
    13. New intermediate phenotype between MED and DD caused by compound heterozygous mutations in the DTDST gene is reported. PMID: 21077204
    14. Characterize transport of oxalate and sulfate by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes. PMID: 20219950
    15. Diminished DTDST expression through epigenetic silencing is associated with colon cancer. PMID: 20460514
    16. DTDST function is crucial for the uptake of extracellular sulfate required for proteoglycan sulfation. PMID: 14692227
    17. The effects of sulfur availablility on proteoglycan sulfation in mice transgenic for a mutation of this gene are reported. PMID: 16719839
    18. This study found an association between single nucleotide polymorphisms of the SLC26A2 gene and juvenile idiopathic arthritis. PMID: 17393463
    19. DTDST is upregulated by dexamethasone stimulation of HT1080 fibrosarcoma cells and is required for fibronectin (FN) extracellular matrix deposition by these cells. PMID: 18056413
    20. A novel SLC26A2 mutation was found in all subjects, inserted by site-directed mutagenesis in a vector harbouring the SLC26A2 cDNA, and expressed in sulfate transport deficient Chinese hamster ovary (CHO) cells to measure sulfate uptake activity PMID: 18708426

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  • 相关疾病：
    Diastrophic dysplasia (DTD); Achondrogenesis 1B (ACG1B); Atelosteogenesis 2 (AO2); Multiple epiphyseal dysplasia 4 (EDM4)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC26A/SulP transporter (TC 2.A.53) family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 10994

    OMIM: 222600

    KEGG: hsa:1836

    STRING: 9606.ENSP00000286298

    UniGene: Hs.302738