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  4. Recombinant Human Suppressor of IKBKE 1 (SIKE1)

Recombinant Human Suppressor of IKBKE 1 (SIKE1)

  • 中文名称：
    人SIKE1重组蛋白
  • 货号：
    CSB-YP887113HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SIKE1重组蛋白
  • 货号：
    CSB-EP887113HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SIKE1重组蛋白
  • 货号：
    CSB-EP887113HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SIKE1重组蛋白
  • 货号：
    CSB-BP887113HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SIKE1重组蛋白
  • 货号：
    CSB-MP887113HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SIKE1
  • Uniprot No.：
  • 别名：
    SIKE1; SIKE; Suppressor of IKBKE 1; Suppressor of IKK-epsilon
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-207
  • 氨基酸序列
    MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA LELIMSKYRK QMLQLMVAKK AVDAEPVLKA HQSHSAEIES QIDRICEMGE VMRKAVQVDD DQFCKIQEKL AQLELENKEL RELLSISSES LQARKENSMD TASQAIK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
  • 基因功能参考文献：
    1. SIKE, a negative regulator of the interferon pathway, attenuates pathological cardiac hypertrophy. PMID: 27249321
    2. Data indicate that suppressor of IKKepsilon (SIKE) inhibits TANK-binding kinase 1 (TBK1)-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essential to type I interferon production. PMID: 23649622
    3. Overexpression of SIKE inhibits virus- and Toll-like receptor 3-triggered interferon-stimulated response elements (ISRE) but not NF-kappa B activation. PMID: 16281057
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    SIKE family
  • 组织特异性：
    Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
  • 数据库链接：

    HGNC: 26119

    OMIM: 611656

    KEGG: hsa:80143

    STRING: 9606.ENSP00000358541

    UniGene: Hs.709277