Recombinant Human Suppressor of cytokine signaling 2 (SOCS2)

1. SOCS2 impairs IFN/JAK/STAT signaling through reducing the stability of tyrosine kinase 2 (TYK2), downregulating the expression of type I and III IFN receptors, attenuating the phosphorylation and nucleus translocation of STAT1. PMID: 28496097
2. High SOCS2 expression is associated with higher grade breast cancer. PMID: 30453988
3. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. PMID: 28216640
4. Overexpression of miR-196b suppresses SOCS2 in human laryngeal squamous cell carcinoma resulting in tumor progression and poor prognosis. PMID: 29753737
5. Methyltransferase-like 3 represses SOCS2 expression in hepatocellular carcinoma through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis PMID: 29171881
6. Study in lung cancer BEAS-2B cells shows that SOCS2 binding to the growth hormone receptor (GHR) is impaired by a GHR threonine substitution at Pro 495. This results in decreased internalisation and degradation of the receptor. PMID: 28967904
7. Despite of the key role of SOCS2 in the regulation of GH receptor signaling, study did not find any significant association between SOCS2 polymorphisms and acromegaly. PMID: 27900634
8. The induction of a tolerogenic phenotype in DCs by NPs was mediated by the AhR-dependent induction of Socs2, which resulted in inhibition of nuclear factor kappaB activation and proinflammatory cytokine production (properties of tolerogenic DCs). PMID: 27330188
9. Long-term palmitate treatment up-regulates SOCS2 and reduces PI3K activity, thereby impairing glucose stimulated insulin secretion. PMID: 27566229
10. Targeting of SOCS2 by miR-194 resulted in derepression of the oncogenic kinases FLT3 and JAK2, leading to enhanced ERK and STAT3 signaling. PMID: 28011622
11. Single-cell RNA sequencing reveals enrichment of homeostatic modules in monocytes and dendritic cells from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNgamma. PMID: 28666115
12. this study shows that IL-7 induces the expression of SOCS2 through the JAK/STAT-5 pathway and that SOCS2 interacts with CD127 in early endosomes and direct the receptor complex to the proteasome for degradation PMID: 27423467
13. Overexpression of SOCS2 inverted these phenotypes generated by hsv2-miR-H9-5p, indicating the potential roles of SOCS2 in Hsv2-miR-H9-5p-driven metastasis in lung cancers. The results highlighted that Hsv2-miR-H9-5p regulated and contributed to bone metastasis of lung cancers. We proposed that Hsv2-miR-H9-5p could be used as a potential target in lung cancer therapy PMID: 28468588
14. Overexpression of SOCS-2 is associated with hepatocellular carcinoma. PMID: 27465557
15. focus on SOCS2 and review its biological function as well as its implication in pathological processes PMID: 26709655
16. SOCS2 may improve outcome of TBI in mice by regulating aspects of the neuroinflammatory response PMID: 27071013
17. This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains. PMID: 25286386
18. crystals of SOCS2 in complex with its adaptor proteins, Elongin C and Elongin B, underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments. PMID: 26121586
19. miR-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression. PMID: 25561270
20. our study indicates that high SOCS2 expression is associated with poor survival in pediatric AML. PMID: 24559289
21. This study shows that over-expression of SOCS2 reduces the psychostimulant effects of amphetamine, enhances PPI, and alters mesolimbic dopaminergic activity. PMID: 25283341
22. The SOCS2 polymorphism (rs3782415) has an influence on the adult height of children with Turner syndrome and growth hormone deficiency after long-term therapy. PMID: 24905066
23. SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer. PMID: 24280133
24. Stage-independent downregulation of SOCS2 and SOCS6 correlate with disease-free survival in colorectal cancer. PMID: 25025962
25. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer. PMID: 24031028
26. SOCS2 associates with activated FLT3 through phosphotyrosine residues 589 and 919, and co-localizes with FLT3 in the cell membrane. PMID: 23548639
27. Estradiol can amplify GH intracellular signaling in human osteoblasts with an essential role played by the reduction of the SOCS2 mediated feedback loop. PMID: 23567159
28. SOCS2 and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis PMID: 23475171
29. Simultaneous stimulation of monocyte-derived DCs resulted in highly increased production of IL-1beta, IL-23 and SOCS2. PMID: 22795647
30. Data demonstrated that suppressor of cytokine signaling 2 (SOCS2) protein level was distinctively increased by saponin, which in turn resulted in inhibition of HCV replication. PMID: 22745742
31. High SOCS2 is associated with idiopathic short stature. PMID: 22768656
32. LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop. PMID: 22291912
33. We propose a model in which SOCS2 acts as a negative regulator of TLR-induced dendritic cell activation PMID: 21844389
34. Data show that knockdown of SOCS2 resulted in the accumulation of p-Pyk2(Tyr402) and blocked NK cell effector functions. PMID: 20543098
35. Probiotic administration increased expression of SOCS-2 and SOCS-3 in Helicobacter pylori infection to limit inflammatory signaling. PMID: 20136974
36. SOCS2 is required for appropriate TLR4 signaling in maturating human DCs via both the MyD88-dependent and -independent signaling pathway PMID: 19779605
37. SOCS-2 is overexpressed in advanced stages of chronic myeloid leukemia. It may be a component of a negative feedback mechanism that is functioning inadequately, induced by Bcr-Abl but unable to reverse its growth-promoting effects. PMID: 11861294
38. SOCS2 mediates the suppression of JAK2 phosphorylation by estrogen, which inhibits growth hormone signaling PMID: 12552091
39. Association of single-nucleotide polymorphisms in the SOCS2 gene with type 2 diabetes in the Japanese was studied. PMID: 16406727
40. Results describe the 1.9-A crystal structure of the ternary complex of SOCS2 with elongin C and elongin B. PMID: 16675548
41. SOCS2 only interacts with the Y1077 motif, but with higher binding affinity and can interfere with CIS and STAT5a prey recruitment at this site. PMID: 16684815
42. Using RT-PCR, we demonstrated for the first time that neutrophils express mRNA for SOCS-2. PMID: 17264307
43. A defect in expression of SOCS-2 and SOCS-3 genes may be crucial for the IGF-I hypersensitivity and progressive increase in erythroid cell population size characteristic of Polycythemia vera. PMID: 17325857
44. Favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. PMID: 17651480
45. analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor PMID: 17666591
46. SOCS2 epigenetic downregulation might be an important second step in the genesis of cytokine-independent myeloproliferative disorder clones PMID: 18769447
47. Acromegalic patients with active disease and hyperplastic polyps had higher levels of SOCS2 transcripts. PMID: 18844680
48. role of SOCS-2 in mediating HIV-1-induced immune evasion and dysregulation of IFNgamma signaling in primary human monocytes PMID: 19279332
49. SOCS2 expression is regulated by STAT5. PMID: 17008382

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HGNC: 19382

OMIM: 605117

KEGG: hsa:8835

STRING: 9606.ENSP00000339428

UniGene: Hs.485572