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  4. Recombinant Human Synaptotagmin-like protein 1 (SYTL1)

Recombinant Human Synaptotagmin-like protein 1 (SYTL1)

  • 货号：
    CSB-YP815582HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP815582HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP815582HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP815582HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP815582HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SYTL1
  • Uniprot No.：
  • 别名：
    exophilin 7; Exophilin-7; JFC1; NADPH oxidase related, C2 domain containing protein; Protein JFC1; PSGL 1; SLP1; Synaptotagmin-like protein 1; SYTL1; SYTL1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-562
  • 氨基酸序列
    MPQRGHPSQE GLWALPSLPM AHGPKPETEG LLDLSFLTEE EQEAIAGVLQ RDARLRQLEE GRVSKLRASV ADPGQLKILT GDWFQEARSQ RHHNAHFGSD LVRASMRRKK STRGDQAPGH DREAEAAVKE KEEGPEPRLT IDEAPQERLR ETEGPDFPSP SVPLKASDPE EASQAQEDPG QGDQQVCAEE ADPELEPASG GEQEPRPQQA QTKAASQILE NGEEAPGPDP SLDRMLSSSS SVSSLNSSTL SGSQMSLSGD AEAVQVRGSV HFALHYEPGA AELRVHVIQC QGLAAARRRR SDPYVKSYLL PDKQSKRKTA VKKRNLNPVF NETLRYSVPQ AELQGRVLSL SVWHRESLGR NIFLGEVEVP LDTWDWGSEP TWLPLQPRVP PSPDDLPSRG LLALSLKYVP AGSEGAGLPP SGELHFWVKE ARDLLPLRAG SLDTYVQCFV LPDDSQASRQ RTRVVRRSLS PVFNHTMVYD GFGPADLRQA CAELSLWDHG ALANRQLGGT RLSLGTGSSY GLQVPWMDST PEEKQLWQAL LEQPCEWVDG LLPLRTNLAP RT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in vesicle trafficking. Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes.
  • 基因功能参考文献：
    1. results reveal that MEIS1, through induction of SYTL1, promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma. PMID: 27018596
    2. High Expression of secretory leukocyte protease inhibitor is associated with metastasis in colorectal cancer. PMID: 25441765
    3. SLPI regulation and activity is altered in the nasal mucosa of smokers. PMID: 24285265
    4. during exocytosis, actin depolymerization commences near the secretory organelle, not the plasma membrane, and secretory granules use a JFC1- and GMIP-dependent molecular mechanism to traverse cortical actin. PMID: 22438581
    5. transcriptional activation of JFC1 by the TNFalpha/NF-kappaB pathway is significant in prostate carcinoma cell lines PMID: 12137562
    6. evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers PMID: 16004602
    7. Levels of mRNA and immunostaining of the antiproteases elafin and SLPI were enhanced strongly in inflamed versus noninflamed UC. Elafin and SLPI may be added to the list of defensin-like peptides with diminished induction in CD versus UC. PMID: 17200145
    8. Slp1 inhibits dense granule secretion in platelets and that Rap1GAP2 modulates secretion by binding to Slp1. PMID: 19528539
    9. Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp1/Jfc1 specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082). PMID: 11773082

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.
  • 组织特异性：
    Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).
  • 数据库链接：

    HGNC: 15584

    OMIM: 608042

    KEGG: hsa:84958

    STRING: 9606.ENSP00000440704

    UniGene: Hs.469175